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词条 Brain-specific angiogenesis inhibitor 1
释义

  1. Function

  2. Interactions

  3. Model organisms

  4. References

  5. External links

  6. Further reading

{{Infobox_gene}}Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[2]

Function

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[3]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]

Model organisms

Model organisms have been used in the study of BAI1 function. A conditional knockout mouse line called Bai1tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]

References

1. ^{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1–2 | pages = 103–8 | date = Apr 1998 | pmid = 9533023 | pmc = | doi = 10.1159/000134693 }}
2. ^{{cite book | author = Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 978-1-4419-7912-4 }}
3. ^1 {{cite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575| accessdate = }}
4. ^{{cite journal | vauthors = Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y | title = Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 251 | issue = 1 | pages = 158–65 | date = Oct 1998 | pmid = 9790924 | doi = 10.1006/bbrc.1998.9408 }}
5. ^{{cite journal | vauthors = Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 597–604 | date = Jun 1998 | pmid = 9647739 | doi = 10.1006/bbrc.1998.8603 }}
6. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
7. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Bai1#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
8. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
9. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
10. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
11. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}
12. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Bai1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}
13. ^1 {{cite web |url=http://www.boneandcartilage.com/ |title=OBCD Consortium}}

External links

  • {{UCSC gene info|ADGRB1}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK | title = Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells | journal = Nature Genetics | volume = 8 | issue = 2 | pages = 171–6 | date = Oct 1994 | pmid = 7531056 | doi = 10.1038/ng1094-171 }}
  • {{cite journal | vauthors = Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T | title = A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis | journal = Oncogene | volume = 15 | issue = 18 | pages = 2145–50 | date = Oct 1997 | pmid = 9393972 | doi = 10.1038/sj.onc.1201542 }}
  • {{cite journal | vauthors = Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 597–604 | date = Jun 1998 | pmid = 9647739 | doi = 10.1006/bbrc.1998.8603 }}
  • {{cite journal | vauthors = Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M | title = Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer | journal = International Journal of Oncology | volume = 13 | issue = 5 | pages = 967–70 | date = Nov 1998 | pmid = 9772287 | doi = 10.3892/ijo.13.5.967 }}
  • {{cite journal | vauthors = Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y | title = Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 251 | issue = 1 | pages = 158–65 | date = Oct 1998 | pmid = 9790924 | doi = 10.1006/bbrc.1998.9408 }}
  • {{cite journal | vauthors = Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T | title = Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1–2 | pages = 75–82 | year = 1999 | pmid = 10343108 | doi = 10.1159/000015219 }}
  • {{cite journal | vauthors = Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA | title = Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 28 | pages = 21477–85 | date = Jul 2000 | pmid = 10748157 | doi = 10.1074/jbc.M909741199 }}
  • {{cite journal | vauthors = Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH, Kee HJ, Kim KK | title = Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein | journal = Brain Research. Molecular Brain Research | volume = 87 | issue = 2 | pages = 223–37 | date = Mar 2001 | pmid = 11245925 | doi = 10.1016/S0169-328X(01)00004-3 }}
  • {{cite journal | vauthors = Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S | title = Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis | journal = British Journal of Cancer | volume = 86 | issue = 3 | pages = 490–6 | date = Feb 2002 | pmid = 11875720 | pmc = 2375213 | doi = 10.1038/sj.bjc.6600067 }}
  • {{cite journal | vauthors = Lim IA, Hall DD, Hell JW | title = Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21697–711 | date = Jun 2002 | pmid = 11937501 | doi = 10.1074/jbc.M112339200 }}
  • {{cite journal | vauthors = Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N | title = Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells | journal = Neuroscience Research | volume = 43 | issue = 1 | pages = 69–74 | date = May 2002 | pmid = 12074842 | doi = 10.1016/S0168-0102(02)00018-4 }}
  • {{cite journal | vauthors = Kaur B, Brat DJ, Calkins CC, Van Meir EG | title = Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression | journal = The American Journal of Pathology | volume = 162 | issue = 1 | pages = 19–27 | date = Jan 2003 | pmid = 12507886 | pmc = 1851137 | doi = 10.1016/S0002-9440(10)63794-7 }}
  • {{cite journal | vauthors = Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG | title = Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 12 | pages = 947–55 | date = Dec 2002 | pmid = 12543931 | doi = 10.1074/mcp.M200066-MCP200 }}
  • {{cite journal | vauthors = Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK | title = Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin | journal = Experimental Cell Research | volume = 294 | issue = 1 | pages = 172–84 | date = Mar 2004 | pmid = 14980512 | doi = 10.1016/j.yexcr.2003.11.008 }}
  • {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = Jul 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }}
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1 : G protein-coupled receptors
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