| 词条 | Brodimoprim |
| 释义 |
| Watchedfields = changed | verifiedrevid = 437202104 | IUPAC_name = 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine | image = Brodimoprim.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 56518-41-3 | ATC_prefix = J01 | ATC_suffix = EA02 | PubChem = 68760 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 62004 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = V1YC7T6LLI | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07238 | ChEBI = 131726 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 31891 | C=13 | H=15 | Br=1 | N=4 | O=2 | molecular_weight = 339.188 g/mol | smiles = Brc1c(OC)cc(cc1OC)Cc2cnc(nc2N)N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = BFCRRLMMHNLSCP-UHFFFAOYSA-N }} Brodimoprim is a structural derivative of trimethoprim. In brodimoprim, the 4-methoxy group of trimethoprim is replaced with a bromine atom. As trimethoprim, brodimoprim is a selective inhibitor of bacterial dihydrofolate reductase.[1] References1. ^{{cite journal |author=Thomson CJ |title=Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria |journal=J Chemother |volume=5 |issue=6 |pages=458–64 |year=1993 |pmid=8195838 |doi=}} {{Sulfonamides and trimethoprim}}{{antibiotic-stub}} 4 : Bacterial dihydrofolate reductase inhibitors|Pyrimidines|Phenol ethers|Organobromides |
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