“Bromperidol”的意思、由来-开放百科全书

词条

Bromperidol

释义

References

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 459984383
| IUPAC_name = 4-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
| image = Bromperidol.svg
| width = 250
| tradename = Bromidol, Bromodol
| Drugs.com = {{drugs.com|international|bromperidol}}
| pregnancy_category =
| legal_status =
| routes_of_administration = Oral
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 10457-90-6
| ATC_prefix = N05
| ATC_suffix = AD06
| PubChem = 2448
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2354
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = LYH6F7I22E
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01101
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 28218
| C=21 | H=23 | Br=1 | F=1 | N=1 | O=2
| molecular_weight = 420.315 g/mol
| smiles = Fc1ccc(cc1)C(=O)CCCN3CCC(O)(c2ccc(Br)cc2)CC3
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RKLNONIVDFXQRX-UHFFFAOYSA-N
}}

Bromperidol (marketed as Bromidol, Bromodol) is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.

References

Poldinger W, Bures E, Haage H, Clinical study with bromperidol, a new butyrophenone derivative, Int Pharmacopsychiatry. 1977;12(1):20-4.
Dubinsky B, McGuire JL, Niemegeers CJ, Janssen PA, Weintraub HS, McKenzie BE, Bromperidol, a new butyrophenone neuroleptic: a review, Psychopharmacology 1982;78(1):1-7.

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