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词条 Bronidox
释义

  1. Uses

  2. See also

  3. References

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| Name =
| ImageFile = Structure of bronidox.png
| ImageSize =
| ImageName =
| IUPACName = 5-Bromo-5-nitro-1,3-dioxane
| SystematicName =
| OtherNames = 5-Bromo-5-nitro-m-dioxane
|Section1={{Chembox Identifiers
| Abbreviations =
| CASNo = 30007-47-7
| CASNo_Ref = {{cascite|correct|??}}
| EINECS = 250-001-7
| EC_number =
| UNNumber =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
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| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI =
| RTECS =
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = U184I9QBNM
| Beilstein =
| Gmelin =
| PubChem = 1807
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 1741
| SMILES = O=[N+]([O-])C1(Br)COCOC1
| InChI = 1/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2
| InChIKey = XVBRCOKDZVQYAY-UHFFFAOYAG
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2
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| 3DMet =
|Section2={{Chembox Properties
| C=4 | H=6 | N=1 | O=4 | Br=1
| Appearance = White crystalline powder
| Density =
| MeltingPtC = 60
| MeltingPt_ref = [1]
58.5−62 °C[2]
| MeltingPt_notes =
| BoilingPt =
| BoilingPt_notes =
| Solubility = insoluble
| SolubleOther =
| Solvent =
| LogP =
| VaporPressure =
| HenryConstant =
| AtmosphericOHRateConstant =
| pKa =
| pKb =
|Section3={{Chembox Structure
| CrystalStruct =
| Coordination =
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|Section4={{Chembox Thermochemistry
| DeltaHf =
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| HeatCapacity = }}
|Section5={{Chembox Pharmacology
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| Pregnancy_US = }}
|Section6={{Chembox Explosive
| ShockSens =
| FrictionSens =
| DetonationV =
| REFactor = }}
|Section7={{Chembox Hazards
| ExternalSDS =
| EUClass =
| MainHazards = Toxic
| NFPA-H =
| NFPA-F =
| NFPA-R =
| NFPA-S =
| RPhrases = {{R22}} {{R38}}
| SPhrases = {{S36}}
| RSPhrases =
| FlashPt =
| AutoignitionPt =
| ExploLimits =
| LD50 = 590 mg/kg (mouse, oral)
455 mg/kg (rat, oral)
31 mg/kg (rat, ipr.)
2500 µg (mouse, skin)
2500 µg (rat, skin)
| PEL =
|Section8={{Chembox Related
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}}

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.

Bronidox causes inhibition of enzyme activity in bacteria.[3]

Bronidox is corrosive to metals.[4]

Uses

  • Bactericide
  • Fungicide, effective against yeast and other fungi{{citation needed|date=April 2016}}
  • It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
  • Stabilizer
  • Surfactant
  • Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
  • Some users do not recommend use in preparations destined for in vivo or tissue culture work[5]

See also

  • Bronopol

References

1. ^5-BROMO-5-NITRO-1,3-DIOXANE {{webarchive|url=https://web.archive.org/web/20160303200521/http://www.chemicalland21.com/lifescience/phar/5-BROMO-5-NITRO-1%2C3-DIOXANE.htm |date=March 3, 2016 }}, chemicalland21.com
2. ^{{cite web|url=http://www.furrental.com/pages/fj/bronidox.pdf |title=Archived copy |accessdate=March 19, 2006 |deadurl=yes |archiveurl=https://web.archive.org/web/20070929124827/http://www.furrental.com/pages/fj/bronidox.pdf |archivedate=September 29, 2007 }}
3. ^{{cite journal |vauthors=Ghannoum M, Thomson M, Bowman W, Al-Khalil S |title=Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox) |journal=Folia Microbiol. (Praha) |volume=31 |issue=1 |pages=19–31 |year=1986 |pmid=3082729 |doi=10.1007/BF02928676 }}
4. ^http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf {{dead link|date=April 2016}}
5. ^  {{webarchive |url=https://web.archive.org/web/20041221152225/http://www.totalreproduction.com/products/specs/Bronidox.html |date=December 21, 2004 }}

4 : Organobromides|Dioxanes|Cationic surfactants|Nitro compounds

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