词条 | B symptoms |
释义 |
B symptoms refer to systemic symptoms of fever, night sweats, and weight loss which can be associated with both Hodgkin's lymphoma and non-Hodgkin's lymphoma. The presence or absence of B symptoms has prognostic significance and is reflected in the staging of these lymphomas. Description and nomenclatureB symptoms are so called because Ann Arbor staging of lymphomas includes both a number (I–IV) and a letter (A or B).[1] "A" indicates the absence of systemic symptoms, while "B" indicates their presence. B symptoms include:
Prognostic importanceThe presence of B symptoms is a marker for more advanced disease with systemic, rather than merely local, involvement. B symptoms are a clear negative prognostic factor in Hodgkin lymphoma.[2] The relevance of B symptoms in non-Hodgkin lymphoma is less clear, although B symptoms tend to correlate with disease that is either more widespread or of a higher histologic grade.[3] Relative importance of specific B symptomsIt has been suggested that, in Hodgkin lymphoma, fever and weight loss are much more prognostically significant than night sweats. In one series of patients with early-stage Hodgkin disease, the presence or absence of night sweats had no impact on cure rates and outcome. However, fever and weight loss had a pronounced negative impact on cure and survival rates, regardless of treatment modality.[4] "B symptoms" in other diseasesSimilar systemic symptoms can be found in non-cancerous states such as tuberculosis and various inflammatory or rheumatologic conditions. In these settings, the term "B symptoms" is sometimes colloquially applied to refer to such systemic or constitutional symptoms. However, in a pure sense, the term "B symptoms" is restricted to lymphoma staging. Also seen in chronic lymphocytic leukemia, Hodgkin’s Lymphoma, Burkitt’s Lymphoma. References1. ^{{cite journal |vauthors=Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M |title=Report of the Committee on Hodgkin's Disease Staging Classification |journal=Cancer Res. |volume=31 |issue=11 |pages=1860–1 |date=November 1971 |pmid=5121694 |doi= |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=5121694}} {{Lymphoid malignancy}}2. ^Reevaluation of prognostic significance of symptoms in Hodgkin's disease. Gobbi PG; Cavalli C; Gendarini A; Crema A; Ricevuti G; Federico M; Di Prisco U; Ascari E. Cancer 1985 Dec 15;56(12):2874–80. 3. ^Malignant lymphoma: the histology and staging of 473 patients at the National Cancer Institute. Anderson T; Chabner BA; Young RC; Berard CW; Garvin AJ; Simon RM; DeVita VT Jr. Cancer 1982 Dec 15;50(12):2699–707. 4. ^Stage I to IIB Hodgkin's disease: the combined experience at Stanford University and the Joint Center for Radiation Therapy. Crnkovich MJ; Leopold K; Hoppe RT; Mauch PM. J Clin Oncol 1987 Jul;5(7):1041–9. 3 : Lymphoma|Paraneoplastic syndromes|Cancer staging |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。