| 词条 | Burkholderia cenocepacia |
| 释义 |
| color = lightgrey | name = Burkholderia cenocepacia | regnum = Bacteria | phylum = Proteobacteria | classis = Betaproteobacteria | ordo = Burkholderiales | familia = Burkholderiaceae | genus = Burkholderia | species = B. cenocepacia | binomial = Burkholderia cenocepacia | binomial_authority = Vandamme et al. 2003 }} Burkholderia cenocepacia is a species of Gram-negative bacteria that is common in the environment, can form a biofilm with itself,[1] is resistant to many antibiotics[2] and may cause disease in plants. PathogenicityIt is an opportunistic pathogen and human infections are common in patients with cystic fibrosis and chronic granulomatous disease, and are often fatal.[3] In cystic fibrosis, it can cause "cepacia syndrome" which is characterized by a rapidly progressive fever, uncontrolled bronchopneumonia, weight loss, and possibly death. A review of B. cenocepacia in respiratory infections of cystic fibrosis patients stated that "one of the most threatening pathogens in [cystic fibrosis] is Burkholderia cenocepacia, a member of a bacterial group collectively referred to as the Burkholderia cepacia complex (Bcc)".[4] 24 Small RNA See also: Burkholderia thailandensis sRNA TaxonomyOriginally defined as B. cepacia, the group has now been split into nine species,[7] and B. cenocepacia is one of the most intensively-studied.[8] MicrobiologyIn addition, the strong environmental protection response of B. cenocepacia is attributed to the biofilm formed by groups of the organism,.[2] This biofilm contains exopolysaccharides (abbreviated EPS) that strengthen the bacterium's resistance to antibiotics. The biofilm exopolysaccharides acted as a barrier to neutrophils from human immune resistance systems, undermining the neutrophil defense action by inhibiting chemotaxis and reducing the production of reactive oxygen species[9] References1. ^{{cite journal |title=Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia |author1=Magdolna Csavas |author2=Lenka Malinovska |author3=Florent Perret |author4=Milan Gyurko |author5=Zita Tunde Illyes |author6=Michaela Wimmerova |author7=Aniko Borbas |date=14 November 2016 |journal=Carbohydrate Research |publisher=Elsevier |volume=437 |pages=1–8 |doi=10.1016/j.carres.2016.11.008 |quote=Burkholderia cenocepacia is a Gram-negative bacterium with the ability to form a biofilm |pmid=27871013}} 2. ^1 {{cite journal |title=Eradication and phenotypic tolerance of Burkholderia cenocepacia biofilms exposed to atmospheric pressure non-thermal plasma |author1=Nida H. Alshraiedeh |author2=Sarah Higginbotham |author3=Padrig B. Flynn |author4=Mahmoud Y. Alkawareek |author5=Michael M. Tunney |author6=Sean P. Gorman |author7=William G. Graham |author8=Brendan F. Gilmore |date=22 April 2016 |journal=International Journal of Antimicrobial Agents |volume=47 |issue=6 |pages=446–450 |doi=10.1016/j.ijantimicag.2016.03.004 |pmid=27179816 |quote=B. cenocepacia can spread from person to person and exhibits intrinsic broad-spectrum antibiotic resistance}} 3. ^{{cite journal |title=Tri- and tetravalent mannoclusters cross-link and aggregate BC2L-A lectin from Burkholderia cenocepacia |author1=Magdolna Csavas |author2=Lenka Malinovska |author3=Florent Perret |author4=Milan Gyurko |author5=Zita Tunde Illyes |author6=Michaela Wimmerova |author7=Aniko Borbas |date=14 November 2016 |journal=Carbohydrate Research |publisher=Elsevier |volume=437 |pages=1–8 |doi=10.1016/j.carres.2016.11.008 |quote=It is recognized as an opportunistic human pathogen causing lung infections in immunocompromised individuals, especially in cystic fibrosis patients, with significant mortality and morbidity}} 4. ^{{cite journal |url=http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)61735-3/fulltext |title=Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence |author1=P. Drevinkek |author2=E. Mahenthiralingam |journal=Clinical Microbiology and Infection |volume=16 |issue=7 |pages=821–830 |doi=10.1111/j.1469-0691.2010.03237.x |accessdate=6 January 2017 |pmid=20880411}} 5. ^{{Cite journal|last=Ramos|first=Christian G.|last2=Grilo|first2=André M.|last3=da Costa|first3=Paulo J. P.|last4=Leitão|first4=Jorge H.|date=February 2013|title=Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315|journal=Genomics|volume=101|issue=2|pages=139–148|doi=10.1016/j.ygeno.2012.10.006|issn=1089-8646|pmid=23142676}} 6. ^{{Cite journal|last=Ghosh|first=Suparna|last2=Dureja|first2=Chetna|last3=Khatri|first3=Indu|last4=Subramanian|first4=Srikrishna|last5=Raychaudhuri|first5=Saumya|last6=Ghosh|first6=Sagarmoy|date=2017-11-03|title=Identification of novel small RNAs in Burkholderia cenocepacia KC-01 expressed under iron limitation and oxidative stress conditions|journal=Microbiology|doi=10.1099/mic.0.000566|issn=1465-2080|pmid=29099689}} 7. ^{{cite journal | author = Lipuma J | title = Update on the Burkholderia cepacia complex. | journal = Curr Opin Pulm Med | volume = 11 | issue = 6 | pages = 528–33 | year = 2005 | pmid = 16217180 | doi = 10.1097/01.mcp.0000181475.85187.ed}} 8. ^{{cite journal | vauthors = Mahenthiralingam E, Vandamme P | title = Taxonomy and pathogenesis of the Burkholderia cepacia complex. | journal = Chron Respir Dis | volume = 2 | issue = 4 | pages = 209–17 | year = 2005 | pmid = 16541604 | doi = 10.1191/1479972305cd053ra}} 9. ^{{cite journal |url=http://www.jbc.org/content/281/5/2526.full.pdf |title=Exopolysaccharides from Burkholderia cenocepacia Inhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species |author1=Johann Bylund |author2=Lee-Anna Burgess |author3=Paola Cescutti |author4=Robert K. Ernst |author5=David P. Speert |date=29 November 2005 |journal=The Journal of Biological Chemistry |volume=281 |issue=5 |pages=2526–2532 |doi=10.1074/jbc.M510692200 |pmid=16316987 |accessdate=6 January 2017 |quote=We showed that EPS from a clinical B. cenocepacia isolate interfered with the function of human neutrophils in vitro; it inhibited chemotaxis and production of reactive oxygen species (ROS), both essential components of innate neutrophil-mediated host defenses}} External links
2 : Burkholderiales|Bacteria described in 2003 |
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