This is a listing of the ministers who served in Busia's Progress Party government during the Second Republic of Ghana. The Second Republic lasted from 1 October 1969 to 13 January 1972.
| Portfolio | Minister | Time frame | Notes |
|---|
| Prime Minister | Kofi Abrefa Busia | 1 October 1969 – 13 January 1972 |
| Deputy Prime Minister | William Ofori Atta
J. Kwesi Lamptey | ? – ? |
| Minister for Foreign Affairs | Patrick Dankwa Anin
Victor Owusu
Patrick Dankwa Anin
Victor Owusu
William Ofori Atta | 1969
1969
1969
1969 – 1971
1971 – 13 January 1972 |
| Minister for Interior | Simon Diedong Dombo
Nicholas Yaw Boafo Adade | 1969 – 1971
1971 – 1972 |
| Minister for Defence | J. Kwesi Lamptey
Bukari Adama | 1969 – 1971
1971 – 1972 |
| Attorney General and Minister for Justice | Victor Owusu | 1 October 1966 – 13 April 1969 |
| Nicholas Yaw Boafo Adade[1] | 14 April 1969 – 1971 |
| Minister for Finance and Economic Planning | Joseph Henry Mensah | 1969 – 1972 |
| Minister for Health | Simon Diedong Dombo
Gibson Dokyi Ampaw | 1971 – 1972
1969 – 1971 |
| Minister for Local Government | Kwabena Kwakye Anti | 1969 – 1971 |
| Minister for Education, Culture and Sport | William Ofori Atta
R. R. Amponsah | 1969 – 1971
1971 – Jan 1972 |
| Minister for Agriculture | Dr. Kwame Safo-Adu[2] | 1969 – 1972 |
| Minister for Trade, Industry and Tourism | Richard Abusua-Yedom Quarshie | 1969 – 1972 |
| Minister for Labour and Social Welfare | Jatoe Kaleo
William Godson Bruce-Konuah | 1969 – 1971
1971 – 1972 |
| Minister for Transport and Communications | Haruna Esseku
Jatoe Kaleo | 1969 – 1971
1971 – 1972 |
| Minister for Works | Samuel Wilberforce Awuku-Darko | 1969 – 1971 |
| Minister for Housing | Dr. William Godson Bruce-Konuah
Samuel Wilberforce Awuku-Darko | 1969 – 1971
1971 – 1972 |
| Minister for Social Development | Akumfi Ameyaw Munufie | ? – ? |
| Minister for Lands, Mineral Resources, Forestry and Wildlife | R. R. Amponsah
T.D. Brodie Mends | 1969 – 1971
1971 – 1972 |
| Minister for Information | T.D. Brodie Mends | 1 October 1969 – 27 January 1971 |
| Minister for Parliamentary Affairs | Bukari Adama
J. Kwesi Lamptey | 1969 – 1971
1971 – 1972 |
| Minister of State (Protocol) | K.G. Osei Bonsu | 1969 – 1972 |
| Portfolio | Minister | Time frame | Notes |
|---|
| Minister for Interior | Kwaku Baah | 1969 – 1972 |
| Minister for Defence | Mohammed Abdul Saaka | 1969 – 1972 |
| Minister for Foreign Affairs | John Agyekum Kufuor | 1969 – 1972 |
| Minister for Works | Walter Horace Kofi Sackey | 1969 – 1972 |
| Minister for Housing | Ofresu Kwabena Poku | 1969 – 1972 |
| Minister for Transport and Communications | Solomon Osei-Akoto,
Joseph Yaw Manu | 1969 – 1972 |
| Minister for Finance and Economic Planning | Jones Ofori Atta,
Charles Omar Nyanor | 1969 – 1972 |
| Minister for Youth and Rural development | Alexander Apeatu Aboagye da Costa,
Carl Daniel Reindorf | 1969 – 1972 |
| Attorney General | Akenten Appiah-Menka | 1969 – 1972 |
| Office of the Prime Minister | Alexander Abu Abedi | 1969 – 1972 |
| Minister for Information | Michael Kwasi Osei | 1969 – 1972 |
| Minister for Labour and Co-operatives | Alfred Badu-Nkansah | 1969 – 1972 |
| Minister for National Service Corps | Samuel Kobina Casely Osei-Baidoo | 1969 – 1972 |
| Minister for Agriculture | Shanni Mahama | 1969 – 1972 |
| Minister for Lands, Mineral Resources, Forestry and Wildlife | Anane Antwi-Kusi,
Daniel Poku Agyekum | 1969 – 1972 |
| Minister for Health | Joseph Godson Amamoo,
Adam Amandi | 1969 – 1972 |
| Minister for Education, Culture and Sports | Sabastien Kwaku Opon,
Oheneba Kow Eduakoh Richardson | 1969 – 1972 |
| Minister for Local Authority | Justice Akuamoa Boateng,
Dr. John Kofi Fynn | 1969 – 1972 |
1. ^{{cite web |title=PAST MINISTERS |url=http://www.mojagd.gov.gh/past-ministers |website=Official website of the government of Ghana |publisher=Government of Ghana |accessdate=11 September 2018}}
2. ^{{cite news |url=http://www.ghanaweb.com/GhanaHomePage/NewsArchive/artikel.php?ID=169755 |title=NPP’s Safo-Adu Is Dead |accessdate=2009-10-04 |work=General News of Saturday, 3 October 2009 |publisher=~Ghana Home Page }}
3. ^{{cite book |last=Danquah |first=Moses |date=1969 |title=The Birth of the Second Republic}}
4. ^{{cite journal |title=Parliamentary debates: National Assembly official report |publisher=Ghana Publications Corporation |page=ii |date=1970}}
{{s-start}}{{s-bef|before=National Liberation Council (1966-1969)}}{{s-ttl|title=Government of Ghana |years=1969 – 1972}}{{s-aft|after=National Redemption Council (1972-1975)}}{{s-end}}{{Ghana governments}}