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词条 Butyrophenone
释义

  1. References

{{Refimprove|date=December 2009}}{{Chembox
| Watchedfields = changed
| verifiedrevid = 414039216
| ImageFileL1=Butyrophenone.svg
| ImageFileR1=Butyrophenone3d.png
| IUPACName=1-phenylbutan-1-one
| OtherNames=
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 9893
| InChI = 1/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
| InChIKey = FFSAXUULYPJSKH-UHFFFAOYAC
| SMILES1 = CCCC(=O)c1ccccc1
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 193524
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = FFSAXUULYPJSKH-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=495-40-9
| PubChem=10315
| SMILES = O=C(c1ccccc1)CCC
}}
|Section2={{Chembox Properties
| Formula=C10H12O
| MolarMass=148.20 g/mol
| Appearance= colorles liquid
| Density=
| MeltingPtC= 12
| BoilingPtC= 229
| Solubility= negligible
| RefractIndex = 1.520
| LogP = 2.77
|Section7={{Chembox Hazards
| MainHazards=
| FlashPtC= 99
| AutoignitionPt =
| NFPA-H = 1
| NFPA-F = 1
| NFPA-R = 1
}}Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.[1]

Examples of butyrophenones include:

  • Haloperidol, the most widely used classical antipsychotic drug in this class[1]
  • Benperidol, the most potent commonly used antipsychotic (200 times more potent than chlorpromazine)[1][2]
  • Droperidol, a commonly used antiemetic for postoperative nausea and vomiting

References

1. ^{{GoodmanGilman11th}}
2. ^{{cite journal|doi=10.1021/jm00316a022|pmid=6037051|title=Ω-Azabicyclic Butyrophenones|journal=Journal of Medicinal Chemistry|volume=10|issue=4|pages=621|year=1967|last1=Grogan|first1=Charles H.|last2=Rice|first2=Leonard M.}}

2 : Aromatic ketones|Phenyl compounds

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