| 释义 |
- Clinical significance
- Interactions
- See also
- References
- External links
- Further reading
{{Infobox_gene}}Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.[1][2] Clinical significance Mutations in CALM2 are associated to {{SWL|type=mutations_associated_to|target= cardiac arrhythmias|label= cardiac arrhythmias}}.[3] Interactions CALM2 has been shown to interact with AKAP9.[4][5] See also References 1. ^{{cite web | title = Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=805| accessdate = }}
2. ^{{cite journal | vauthors = SenGupta B, Friedberg F, Detera-Wadleigh SD | title = Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species | journal = J. Biol. Chem. | volume = 262 | issue = 34 | pages = 16663–70 | date = December 1987 | pmid = 2445749 | doi = }}
3. ^{{cite journal | vauthors = Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL | title = Novel calmodulin mutations associated with congenital arrhythmia susceptibility | journal = Circ Cardiovasc Genet | volume = 7 | issue = 4 | pages = 466–74 | year = 2014 | pmid = 24917665 | pmc = 4140998 | doi = 10.1161/CIRCGENETICS.113.000459 }}
4. ^{{cite journal | vauthors = Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y | title = Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex | journal = Mol. Biol. Cell | volume = 13 | issue = 9 | pages = 3235–45 | date = Sep 2002 | pmid = 12221128 | pmc = 124155 | doi = 10.1091/mbc.E02-02-0112 }}
5. ^{{cite journal | vauthors = Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE | title = Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3 | journal = Genomics | volume = 16 | issue = 2 | pages = 461–5 | date = May 1993 | pmid = 8314583 | doi = 10.1006/geno.1993.1211 }}
External links Further reading {{refbegin | 2}}- {{cite journal | vauthors = Zhang M, Yuan T | title = Molecular mechanisms of calmodulin's functional versatility | journal = Biochem. Cell Biol. | volume = 76 | issue = 2-3 | pages = 313–23 | year = 1998 | pmid = 9923700 | doi = 10.1139/bcb-76-2-3-313 }}
- {{cite journal | vauthors = Gusev NB | title = Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation | journal = Biochemistry Mosc. | volume = 66 | issue = 10 | pages = 1112–21 | year = 2001 | pmid = 11736632 | doi = 10.1023/A:1012480829618 }}
- {{cite journal | vauthors = Benaim G, Villalobo A | title = Phosphorylation of calmodulin. Functional implications | journal = Eur. J. Biochem. | volume = 269 | issue = 15 | pages = 3619–31 | year = 2002 | pmid = 12153558 | doi = 10.1046/j.1432-1033.2002.03038.x }}
- {{cite journal | vauthors = Koller M, Schnyder B, Strehler EE | title = Structural organization of the human CaMIII calmodulin gene | journal = Biochim. Biophys. Acta | volume = 1087 | issue = 2 | pages = 180–9 | year = 1990 | pmid = 2223880 | doi = 10.1016/0167-4781(90)90203-e }}
- {{cite journal | vauthors = Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD | title = Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C | journal = Biochemistry | volume = 26 | issue = 10 | pages = 2886–93 | year = 1987 | pmid = 3111527 | doi = 10.1021/bi00384a033 }}
- {{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | year = 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
- {{cite journal | vauthors = Srinivas SK, Srinivas RV, Anantharamaiah GM, Compans RW, Segrest JP | title = Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins | journal = J. Biol. Chem. | volume = 268 | issue = 30 | pages = 22895–9 | year = 1993 | pmid = 8226798 | doi = }}
- {{cite journal | vauthors = Miller MA, Mietzner TA, Cloyd MW, Robey WG, Montelaro RC | title = Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein | journal = AIDS Res. Hum. Retroviruses | volume = 9 | issue = 11 | pages = 1057–66 | year = 1993 | pmid = 8312049 | doi = 10.1089/aid.1993.9.1057 }}
- {{cite journal | vauthors = Radding W, Pan ZQ, Hunter E, Johnston P, Williams JP, McDonald JM | title = Expression of HIV-1 envelope glycoprotein alters cellular calmodulin | journal = Biochem. Biophys. Res. Commun. | volume = 218 | issue = 1 | pages = 192–7 | year = 1996 | pmid = 8573130 | doi = 10.1006/bbrc.1996.0034 }}
- {{cite journal | vauthors = Pan Z, Radding W, Zhou T, Hunter E, Mountz J, McDonald JM | title = Role of calmodulin in HIV-potentiated Fas-mediated apoptosis | journal = Am. J. Pathol. | volume = 149 | issue = 3 | pages = 903–10 | year = 1996 | pmid = 8780394 | pmc = 1865159 | doi = }}
- {{cite journal | vauthors = Sasaki M, Uchiyama J, Ishikawa H, Matsushita S, Kimura G, Nomoto K, Koga Y | title = Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV | journal = Virology | volume = 224 | issue = 1 | pages = 18–24 | year = 1996 | pmid = 8862395 | doi = 10.1006/viro.1996.0502 }}
- {{cite journal | vauthors = Brigino E, Haraguchi S, Koutsonikolis A, Cianciolo GJ, Owens U, Good RA, Day NK | title = Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 7 | pages = 3178–82 | year = 1997 | pmid = 9096366 | pmc = 20342 | doi = 10.1073/pnas.94.7.3178 }}
- {{cite journal | vauthors = Minakami R, Jinnai N, Sugiyama H | title = Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro | journal = J. Biol. Chem. | volume = 272 | issue = 32 | pages = 20291–8 | year = 1997 | pmid = 9242710 | doi = 10.1074/jbc.272.32.20291 }}
- {{cite journal | vauthors = Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY | title = Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin | journal = Nature | volume = 388 | issue = 6645 | pages = 882–7 | year = 1997 | pmid = 9278050 | doi = 10.1038/42264 }}
- {{cite journal | vauthors = Malvoisin E, Wild F | title = Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin | journal = Virus Res. | volume = 50 | issue = 2 | pages = 119–27 | year = 1997 | pmid = 9282777 | doi = 10.1016/S0168-1702(97)00060-9 }}
- {{cite journal | vauthors = Martoglio B, Graf R, Dobberstein B | title = Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin | journal = EMBO J. | volume = 16 | issue = 22 | pages = 6636–45 | year = 1997 | pmid = 9362478 | pmc = 1170268 | doi = 10.1093/emboj/16.22.6636 }}
- {{cite journal | vauthors = Ishikawa H, Sasaki M, Noda S, Koga Y | title = Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin | journal = J. Virol. | volume = 72 | issue = 8 | pages = 6574–80 | year = 1998 | pmid = 9658102 | pmc = 109834 | doi = }}
- {{cite journal | vauthors = Toutenhoofd SL, Foletti D, Wicki R, Rhyner JA, Garcia F, Tolon R, Strehler EE | title = Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3 | journal = Cell Calcium | volume = 23 | issue = 5 | pages = 323–38 | year = 1998 | pmid = 9681195 | doi = 10.1016/S0143-4160(98)90028-8 }}
{{refend}}{{PDB Gallery|geneid=805}}{{protein-stub}} 1 : EF-hand-containing proteins |