| 词条 | Calyculin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | Name = Calyculins | verifiedrevid = 460015289 | ImageFile = Calyculin.png | ImageSize = | ImageCaption = Calyculins A and C | IUPACName = ((2R,3R,5R,7R,8S,9S)-2-((1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl)-9-((E)-3-(2-((2S)-4-(((2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl)amino)butan-2-yl)-1,3-oxazol-4-yl)prop-2-enyl)-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro(4.5)decan-3-yl) dihydrogen phosphate (Calyculin A)[1] | OtherNames = |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9084513 | ChemSpiderID_Comment = (Calyculin A) | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Comment = (Calyculin A) | StdInChI = 1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FKAWLXNLHHIHLA-LIKMAGLISA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo = 101932-71-2 | CASNo_Comment = (Calyculin A) | PubChem = 10909255 | PubChem_Comment = (Calyculin A) | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 384277 | SMILES = }} |Section2={{Chembox Properties | Formula = C51H83N4O15P (Calyculin C) | MolarMass = 1023.2 g/mol (Calyculin C) | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} Calyculins are natural products originally isolated from the marine sponge Discodermia calyx.[2] Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential anticancer agents. References1. ^{{cite web| title=Calyculin A| date=2015-01-02| website=Cell Signaling Technology| url=https://media.cellsignal.com/pdf/9902.pdf}} {{organic-compound-stub}}{{Oncology-stub}}2. ^{{cite journal| title = Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin| vauthors = Suganuma M, Fujiki H, Furuya-Suguri H, Yoshizawa S, Yasumoto S, Kato Y, Fusetani N, Sugimura T| journal = Cancer Res.| year = 1990| volume = 50| issue =12| pages = 3521–3525}} 3 : Organophosphates|Nitriles|Spiro compounds |
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