“CAMK2A”的意思、由来-开放百科全书

Function

The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca2+/calmodulin-dependent protein kinase II subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning.{{citation needed|date=October 2018}} In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]

References

1. ^{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 6 | issue = 1 | pages = 63–70 | date = Jul 1999 | pmid = 10231032 | pmc = | doi = 10.1093/dnares/6.1.63 }}
2. ^{{cite journal | vauthors = Lin CR, Kapiloff MS, Durgerian S, Tatemoto K, Russo AF, Hanson P, Schulman H, Rosenfeld MG | title = Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase | journal = Proc Natl Acad Sci U S A | volume = 84 | issue = 16 | pages = 5962–6 | date = Sep 1987 | pmid = 3475713 | pmc = 298983 | doi = 10.1073/pnas.84.16.5962 }}
3. ^{{cite web | title = Entrez Gene: CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=815| accessdate = }}
4. ^{{cite journal | vauthors = Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB |authorlink6=Mary B. Kennedy| title = Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin | journal = J. Neurosci. | volume = 21 | issue = 2 | pages = 423–33 | date = Jan 2001 | pmid = 11160423 | doi = }}
5. ^{{cite journal | vauthors = Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH | title = The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner | journal = J. Neurosci. | volume = 22 | issue = 18 | pages = 7879–91 | date = Sep 2002 | pmid = 12223541 | doi = }}
6. ^{{cite journal | vauthors = Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M | title = CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44745–52 | date = Nov 2003 | pmid = 12933808 | doi = 10.1074/jbc.M303576200 }}

Further reading

{{cite journal | vauthors = Soderling TR | title = CaM-kinases: modulators of synaptic plasticity. | journal = Curr. Opin. Neurobiol. | volume = 10 | issue = 3 | pages = 375–80 | year = 2000 | pmid = 10851169 | doi = 10.1016/S0959-4388(00)00090-8 }}

{{cite journal | vauthors = Hook SS, Means AR | title = Ca(2+)/CaM-dependent kinases: from activation to function. | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 41 | issue = 1 | pages = 471–505 | year = 2001 | pmid = 11264466 | doi = 10.1146/annurev.pharmtox.41.1.471 }}

{{cite journal | vauthors = Yamamoto H | title = [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] | journal = Tanpakushitsu Kakusan Koso | volume = 47 | issue = 3 | pages = 241–7 | year = 2002 | pmid = 11889801 | doi = }}

{{cite journal | vauthors = Countaway JL, Nairn AC, Davis RJ | title = Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase. | journal = J. Biol. Chem. | volume = 267 | issue = 2 | pages = 1129–40 | year = 1992 | pmid = 1309762 | doi = }}

{{cite journal | vauthors = Wegner M, Cao Z, Rosenfeld MG | title = Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. | journal = Science | volume = 256 | issue = 5055 | pages = 370–3 | year = 1992 | pmid = 1314426 | doi = 10.1126/science.256.5055.370 }}

{{cite journal | vauthors = Omary MB, Baxter GT, Chou CF, Riopel CL, Lin WY, Strulovici B | title = PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. | journal = J. Cell Biol. | volume = 117 | issue = 3 | pages = 583–93 | year = 1992 | pmid = 1374067 | pmc = 2289443 | doi = 10.1083/jcb.117.3.583 }}

{{cite journal | vauthors = Bredt DS, Ferris CD, Snyder SH | title = Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. | journal = J. Biol. Chem. | volume = 267 | issue = 16 | pages = 10976–81 | year = 1992 | pmid = 1375933 | doi = }}

{{cite journal | vauthors = Tokui T, Yamauchi T, Yano T, Nishi Y, Kusagawa M, Yatani R, Inagaki M | title = Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins. | journal = Biochem. Biophys. Res. Commun. | volume = 169 | issue = 3 | pages = 896–904 | year = 1990 | pmid = 2114109 | doi = 10.1016/0006-291X(90)91977-Z }}

{{cite journal | vauthors = Inagaki M, Gonda Y, Nishizawa K, Kitamura S, Sato C, Ando S, Tanabe K, Kikuchi K, Tsuiki S, Nishi Y | title = Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain. | journal = J. Biol. Chem. | volume = 265 | issue = 8 | pages = 4722–9 | year = 1990 | pmid = 2155236 | doi = }}

{{cite journal | vauthors = Ohta Y, Ohba T, Miyamoto E | title = Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 14 | pages = 5341–5 | year = 1990 | pmid = 2164678 | pmc = 54319 | doi = 10.1073/pnas.87.14.5341 }}

{{cite journal | vauthors = Lee RH, Brown BM, Lolley RN | title = Protein kinase A phosphorylates retinal phosducin on serine 73 in situ. | journal = J. Biol. Chem. | volume = 265 | issue = 26 | pages = 15860–6 | year = 1990 | pmid = 2394752 | doi = }}

{{cite journal | vauthors = Ku NO, Omary MB | title = Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. | journal = J. Cell Biol. | volume = 127 | issue = 1 | pages = 161–71 | year = 1994 | pmid = 7523419 | pmc = 2120194 | doi = 10.1083/jcb.127.1.161 }}

{{cite journal | vauthors = Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E | title = Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. | journal = J. Biol. Chem. | volume = 270 | issue = 13 | pages = 7679–88 | year = 1995 | pmid = 7706316 | doi = 10.1074/jbc.270.13.7679 }}

{{cite journal | vauthors = Tsujimura K, Tanaka J, Ando S, Matsuoka Y, Kusubata M, Sugiura H, Yamauchi T, Inagaki M | title = Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II. | journal = J. Biochem. | volume = 116 | issue = 2 | pages = 426–34 | year = 1995 | pmid = 7822264 | doi = }}

{{cite journal | vauthors = Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan DH | title = Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. | journal = J. Biol. Chem. | volume = 269 | issue = 42 | pages = 26492–6 | year = 1994 | pmid = 7929371 | doi = }}

{{cite journal | vauthors = Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME | title = A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. | journal = Mol. Cell. Biol. | volume = 13 | issue = 10 | pages = 6260–73 | year = 1993 | pmid = 8413226 | pmc = 364685 | doi = 10.1128/mcb.13.10.6260}}

{{cite journal | vauthors = Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB | title = Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. | journal = J. Biol. Chem. | volume = 271 | issue = 49 | pages = 31670–8 | year = 1997 | pmid = 8940188 | doi = 10.1074/jbc.271.49.31670 }}

{{cite journal | vauthors = Rotenberg A, Mayford M, Hawkins RD, Kandel ER, Muller RU | title = Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. | journal = Cell | volume = 87 | issue = 7 | pages = 1351–61 | year = 1997 | pmid = 8980240 | doi = 10.1016/S0092-8674(00)81829-2 }}

{{cite journal | vauthors = Paudel HK | title = The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. | journal = J. Biol. Chem. | volume = 272 | issue = 3 | pages = 1777–85 | year = 1997 | pmid = 8999860 | doi = 10.1074/jbc.272.3.1777 }}

Function

Interactions

References

Further reading

External links