| 词条 | Cantuzumab |
| 释义 |
It is typically linked to one of several cytotoxic agents, yielding antibody-drug conjugates :
huC242 targets CanAg"HuC242 binds to the extracellular domain of the tumor-associated carbohydrate antigen known as CanAg (a novel glycoform of MUC1). CanAg is strongly expressed in most pancreatic, biliary, and colorectal cancers. It is also expressed in a substantial proportion of gastric cancers (55%), uterine cancers (45%), non-small cell lung cancers (40%), and bladder cancers (40%)."[2] References1. ^{{cite journal| pmid=18301896 | doi=10.1007/s00280-007-0672-8 | volume=62 | title=Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study | year=2008 | journal=Cancer Chemother Pharmacol | pages=911–9 | last1 = Rodon | first1 = J | last2 = Garrison | first2 = M | last3 = Hammond | first3 = LA | last4 = de Bono | first4 = J | last5 = Smith | first5 = L | last6 = Forero | first6 = L | last7 = Hao | first7 = D | last8 = Takimoto | first8 = C | last9 = Lambert | first9 = JM | last10 = Pandite | first10 = L | last11 = Howard | first11 = M | last12 = Xie | first12 = H | last13 = Tolcher | first13 = AW}} {{monoclonal-antibody-stub}}2. ^A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors. Helft et al. 2004 1 : Monoclonal antibodies |
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