| 词条 | Caprylic acid |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443496721 | ImageFile = Caprylic acid.svg | ImageName = Skeletal formula | ImageFile1 = Caprylic-acid-3D-balls.png | ImageName1 = Ball-and-stick model | IUPACName = octanoic acid | OtherNames = C8:0 (Lipid numbers) |Section1={{Chembox Identifiers | IUPHAR_ligand = 4585 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = OBL58JN025 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D05220 | InChI = 1/C8H16O2/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3,(H,9,10) | InChIKey = WWZKQHOCKIZLMA-UHFFFAOYAH | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 324846 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C8H16O2/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3,(H,9,10) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WWZKQHOCKIZLMA-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 124-07-2 | PubChem = 379 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 370 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB04519 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 28837 | SMILES = CCCCCCCC(=O)O | EINECS = 204-677-5 |Section2={{Chembox Properties | C = 8 | H = 16 | O = 2 | Appearance = Oily colorless liquid | Odor = faint, fruity-acid; irritating | Density = 0.910 g/cm3[1] | MeltingPtC = 16.7 | MeltingPt_ref = [1] | BoilingPtC = 239.7 | BoilingPt_ref = [2] | Solubility = 0.068 g/100 mL[2] | SolubleOther = soluble in alcohol, chloroform, ether, CS2, petroleum ether, acetonitrile | pKa = 4.89[3] 1.055[4] 1.53[5] | LogP = 3.05 | RefractIndex = 1.4285 | VaporPressure = 0.25 Pa | MagSus = -101.60·10−6 cm3/mol |Section4={{Chembox Thermochemistry | DeltaHf = -636 kJ/mol | HeatCapacity = 297.9 J/K mol |Section7={{Chembox Hazards | MainHazards = | FlashPtC = 130 | AutoignitionPtC = 440 | NFPA-H = 3 | NFPA-F = 0 | NFPA-R = 1 | NFPA-S = COR | LD50 = 10.08 g/kg (orally in rats)[2] |Section8={{Chembox Related | OtherCompounds = Heptanoic acid, Nonanoic acid }}Caprylic acid is the common name for the eight-carbon saturated fatty acid known by the systematic name octanoic acid. Its compounds are found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil.[1] It is an oily liquid that is minimally soluble in water with a slightly unpleasant rancid-like smell and taste.[2] Two other acids are named after goats via the Latin word capra: caproic acid (C6) and capric acid (C10). Along with caprylic acid (C8) these total 15% in goat milk fat. UsesCaprylic acid is used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Caprylic acid is an antimicrobial pesticide used as a food contact surface sanitizer in commercial food handling establishments on dairy equipment, food processing equipment, breweries, wineries, and beverage processing plants. It is also used as disinfectant in health care facilities, schools/colleges, animal care/veterinary facilities, industrial facilities, office buildings, recreational facilities, retail and wholesale establishments, livestock premises, restaurants, and hotels/motels. In addition, caprylic acid is used as an algaecide, bactericide, fungicide, and herbicide in nurseries, greenhouses, garden centers, and interiorscapes on ornamentals. Products containing caprylic acid are formulated as soluble concentrate/liquids and ready-to-use liquids.[6] For ghrelin to have a hunger-stimulating action on a hypothalamus, caprylic acid must be linked to a serine residue at the 3-position of ghrelin. To cause hunger, it must acylate an -OH group. Other fatty acids in the same position have similar effects on hunger. The acid chloride of caprylic acid is used in the synthesis of perfluorooctanoic acid. Dietary uses{{see also|Medium-chain triglyceride#Dietary relevance}}Caprylic acid is taken as a dietary supplement. Some studies have shown that medium-chain triglycerides (MCTs) can help in the process of excess calorie burning, and thus weight loss;[7][8][9][10][11] however, a systematic review of the evidence concluded that the overall results are inconclusive.[12] Also, interest in MCTs has been shown by endurance athletes and the bodybuilding community, but MCTs are not beneficial to improved exercise performance.[11] References1. ^1 {{cite journal |year=2001 |title=Lexicon of lipid nutrition (IUPAC Technical Report) |journal=Pure and Applied Chemistry |volume=73 |issue=4 |pages=685–744 |url=http://iupac.org/publications/pac/73/4/0685/ |doi=10.1351/pac200173040685 |last1=Beare-Rogers |first1=J. |last2=Dieffenbacher |first2=A. |last3=Holm |first3=J.V. }} 2. ^1 2 3 4 {{Merck12th}} 3. ^{{cite book | author=Lide, D. R. (Ed.) | title=CRC Handbook of Chemistry and Physics (70th Edn.) | publisher=Boca Raton (FL):CRC Press | year=1990}} 4. ^at 2.06–2.63 K 5. ^at −191 °C 6. ^EPA - Antimicrobials Division. Docket Number; EPA-HQ-OPP-2008-0477 Caprylic (Octanoic) Acid. 7. ^{{cite journal| title = Medium-chain triglycerides|author1=B. Martena |author2=M. Pfeuffer |author3=J. Schrezenmeir |journal= International Dairy Journal |volume= 16| issue= 11|year= 2006| pages =1374–1382 |doi=10.1016/j.idairyj.2006.06.015|pmc=2020023}} 8. ^{{Cite journal | last1 = Takeuchi | first1 = H | last2 = Sekine | first2 = S | last3 = Kojima | first3 = K | last4 = Aoyama | first4 = T | title = The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation | journal = Asia Pacific journal of clinical nutrition | volume = 17 Suppl 1 | pages = 320–3 | year = 2008 | pmid = 18296368}} 9. ^{{Cite journal | last1 = St-Onge | first1 = MP | last2 = Jones | first2 = PJ | title = Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity | journal = The Journal of Nutrition | volume = 132 | issue = 3 | pages = 329–32 | year = 2002 | pmid = 11880549}} 10. ^{{Cite journal | last1 = Papamandjaris | first1 = AA | last2 = MacDougall | first2 = DE | last3 = Jones | first3 = PJ | title = Medium chain fatty acid metabolism and energy expenditure: obesity treatment implications | journal = Life Sciences | volume = 62 | issue = 14 | pages = 1203–15 | year = 1998 | pmid = 9570335 | doi=10.1016/S0024-3205(97)01143-0}} 11. ^1 {{Cite journal | last1 = Clegg | first1 = M. E. | title = Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance | journal = International Journal of Food Sciences and Nutrition | volume = 61 | issue = 7 | pages = 653–679 | year = 2010 | pmid = 20367215 | doi = 10.3109/09637481003702114}} 12. ^{{Cite journal | journal = Nutr Hosp | date = 2012 | volume = 27 | issue = 1 | pages = 103–108 | doi= 10.1590/S0212-16112012000100011 | title = Influence of the dietary intake of medium chain triglycerides on body composition, energy expenditure and satiety: a systematic review |vauthors=Rego Costa AC, Rosado EL, Soares-Mota M | pmid = 22566308}} External links
5 : Fatty acids|Biologically-based therapies|Antifungals|Alkanoic acids|Octanoates |
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