“Carbonyl reductase (NADPH)”的意思、由来-开放百科全书

词条

Carbonyl reductase (NADPH)

释义

Structural studies
References

{{enzyme
| Name = carbonyl reductase (NADPH)
| EC_number = 1.1.1.184
| CAS_number = 89700-36-7
| IUBMB_EC_number = 1/1/1/184
| GO_code = 0004090
| image = 1cyd.jpg
| width = 270
| caption = carbonyl reductase tetramer, Mouse
}}

In enzymology, a carbonyl reductase (NADPH) ({{EC number|1.1.1.184}}) is an enzyme that catalyzes the chemical reaction

R-CO-R' + NADPH + H⁺ :R-CHOH-R' + NADP⁺

Thus, the two products of this enzyme are R-CHOH-R' and NADP⁺, whereas its 3 substrates are R-CO-R', NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is secondary-alcohol:NADP⁺ oxidoreductase. Other names in common use include aldehyde reductase 1, prostaglandin 9-ketoreductase, xenobiotic ketone reductase, NADPH-dependent carbonyl reductase, ALR3, carbonyl reductase, nonspecific NADPH-dependent carbonyl reductase, aldehyde reductase 1, and carbonyl reductase (NADPH). This enzyme participates in arachidonic acid metabolism, and has recently been shown to catabolize S-Nitrosoglutathione, as a means to degrade NO in an NADPH-dependent manner.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1CYD}}, {{PDB link|1WMA}}, {{PDB link|2HRB}}, and {{PDB link|2PFG}}.

References

{{cite journal | vauthors = Ahmed NK, Felsted RL, Bachur NR | date = 1978 | title = Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers | journal = Biochem. Pharmacol. | volume = 27 | pages = 2713–9 | pmid = 31888 | doi = 10.1016/0006-2952(78)90047-3 | issue = 23 }}
{{cite journal | vauthors = Lin YM, Jarabak J | date = 1978 | title = Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition | journal = Biochem. Biophys. Res. Commun. | volume = 81 | pages = 1227–34 | pmid = 666816 | doi = 10.1016/0006-291X(78)91267-6 | issue = 4 }}
{{cite journal | author = Wermuth B | date = 1981 | title = Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase | journal = J. Biol. Chem. | volume = 256 | pages = 1206–13 | pmid = 7005231 | issue = 3 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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