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词条 (carboxyethyl)arginine beta-lactam-synthase
释义

  1. References

  2. Further reading

{{enzyme
| Name = (carboxyethyl)arginine beta-lactam-synthase
| EC_number = 6.3.3.4
| CAS_number = 68247-54-1
| IUBMB_EC_number = 6/3/3/4
| GO_code = 0034027
| image = 1mc1.png
| width =
| caption = beta-lactam synthetase. PDB 1mc1 [1]
}}

In enzymology, a (carboxyethyl)arginine beta-lactam-synthase ({{EC number|6.3.3.4}}) is an enzyme that catalyzes the chemical reaction

ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

References

1. ^{{Cite journal | last1 = Miller | first1 = M. T. | last2 = Bachmann | first2 = B. O. | last3 = Townsend | first3 = C. A. | last4 = Rosenzweig | first4 = A. C. | title = The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots | doi = 10.1073/pnas.232361199 | journal = Proceedings of the National Academy of Sciences | volume = 99 | issue = 23 | pages = 14752–14757 | year = 2002 | pmid = 12409610 | pmc =137491 }}

Further reading

  • {{cite journal | vauthors = Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI | author6-link = Edward I. Solomon | date = 2001 | title = Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities | journal = J. Am. Chem. Soc. | volume = 123 | pages = 7388–98 | pmid = 11472170 | doi = 10.1021/ja004025 | issue = 30 }}
  • {{cite journal | author = Townsend CA | date = 2002 | title = New reactions in clavulanic acid biosynthesis | journal = Curr. Opin. Chem. Biol. | volume = 6 | pages = 583–9 | pmid = 12413541 | doi = 10.1016/S1367-5931(02)00392-7 | issue = 5 }}
  • {{cite journal | vauthors = Bachmann BO, Li R, Townsend CA | date = 1998 | title = β-Lactam synthetase: A new biosynthetic enzyme | journal = Proc. Natl. Acad. Sci. | volume = 95 | pages = 9082–6 | pmid = 9689037 | doi = 10.1073/pnas.95.16.9082 | issue = 16 | pmc = 21295 }}
{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Carboxyethylarginine beta-lactam-synthase}}{{6.3-enzyme-stub}}

2 : EC 6.3.3|Enzymes of unknown structure
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