| 词条 | Cathepsin L |
| 释义 |
| Name = Cathepsin L | EC_number = 3.4.22.15 | CAS_number = 60616-82-2 | IUBMB_EC_number = 3/4/22/15 | GO_code = | image = | width = | caption = }}Cathepsin L ({{EC number|3.4.22.15}}, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation.[1][2][3][4] It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. [5] Cathepsin L has been reported in many organisms including fish,[6] birds, mammals, and sponges. [7] See also
References1. ^{{cite journal | title = Cathepsin B, cathepsin H and cathepsin L |author1 = Barrett, A.J. |author2 =Kirschke, H. |journal = Methods Enzymol. |year = 1981 |volume = 80 |pages = 535–561 |pmid = 7043200 |doi=10.1016/s0076-6879(81)80043-2}} 2. ^{{cite journal | title = Lysosomal cysteine proteinases |author1 = Barrett, A.J. |author2 =Buttle, D.J. |author3 =Mason, R.W. |journal = ISI Atlas of Science. Biochemistry |year = 1988 |volume = 1 |pages = 256–260 |pmid = }} 3. ^{{cite journal | title = Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts |author1 = Joseph, L.J. |author2 =Chang, L.C. |author3 =Stamenkovich, D. |author4 =Sukhatme, V.P. |journal = J. Clin. Invest. |year = 1988 |volume = 81 |pages = 1621–1629 |pmid = 2835398 |doi=10.1172/JCI113497 |pmc=442598}} 4. ^{{cite journal | title = Active center differences between cathepsins L and B: the S1 binding region |author1 = Kirschke, H. |author2 =Wikstrom, P. |author3 =Shaw, E. |journal = FEBS Lett. |year = 1988 |volume = 228 |pages = 128–130 |pmid = 3342870 |issue=1 |doi=10.1016/0014-5793(88)80600-8}} 5. ^Dickinson DP. Cysteine Peptidases of Mammals: Their Biological Roles and Potential Effects in the Oral Cavity and Other Tissues in Health and Disease, CROBM 2002 13: 238. 6. ^{{cite journal | title = A murrel cysteine protease, cathepsin L: bioinformatics characterization, gene expression and proteolytic activity |vauthors = Venkatesh K, Prasanth B, Rajesh P, Annie JG, Mukesh P, Jesu A |journal = Biologia |year = 2014 |volume = 39 |pages = 395–406 |doi=10.2478/s11756-013-0326-8}} 7. ^Sevenich L, Pennacchio LA, Peters C, Reinheckel T.Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem. 2006 Jul;387(7):885-91. External links
2 : EC 3.4.22|Cathepsins |
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