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词条 CBX1
释义

  1. Function

  2. Model organisms

  3. Interactions

  4. See also

  5. References

  6. Further reading

  7. External links

{{Infobox_gene}}Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.[1][2]

Function

The protein is localized at heterochromatin sites, where it mediates gene silencing.[2]

Model organisms

Model organisms have been used in the study of CBX1 function. A conditional knockout mouse line, called Cbx1tm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty two tests were carried out and two phenotypes were reported. No homozygous mutant animals survived until two weeks of age, therefore the remaining tests were carried out on heterozygous mutant mice. Male heterozygotes showed increased VO2, rate of elimination of carbon dioxide, and energy expenditure as determined by indirect calorimetry.[4]

Interactions

CBX1 has been shown to interact with:

{{div col|colwidth=20em}}
  • C11orf30,[12]
  • CBX3[16] and
  • CBX5,[13] and
  • SUV39H1.[14]
{{Div col end}}

See also

  • Heterochromatin protein 1

References

1. ^{{cite journal | vauthors = Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM | title = Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis | journal = Chromosoma | volume = 106 | issue = 1 | pages = 11–9 | date = Jun 1997 | pmid = 9169582 | pmc = | doi = 10.1007/s004120050219 }}
2. ^1 {{cite web | title = Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10951| accessdate = }}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAT/indirect-calorimetry/ |title=Indirect calorimetry data for Cbx1 |publisher=Wellcome Trust Sanger Institute}}
4. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
5. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
6. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Cbx1 |title=International Knockout Mouse Consortium}}
7. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432508 |title=Mouse Genome Informatics}}
8. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
9. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
10. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
11. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}
12. ^{{cite journal | vauthors = Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T | title = EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer | journal = Cell | volume = 115 | issue = 5 | pages = 523–35 | date = Nov 2003 | pmid = 14651845 | doi = 10.1016/s0092-8674(03)00930-9}}
13. ^1 {{cite journal | vauthors = Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R | title = Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins | journal = Molecular Cell | volume = 7 | issue = 4 | pages = 729–39 | date = Apr 2001 | pmid = 11336697 | doi = 10.1016/S1097-2765(01)00218-0}}
14. ^{{cite journal | vauthors = Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T | title = Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 | journal = The EMBO Journal | volume = 18 | issue = 7 | pages = 1923–38 | date = Apr 1999 | pmid = 10202156 | pmc = 1171278 | doi = 10.1093/emboj/18.7.1923 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Lessard J, Baban S, Sauvageau G | title = Stage-specific expression of polycomb group genes in human bone marrow cells | journal = Blood | volume = 91 | issue = 4 | pages = 1216–24 | date = Feb 1998 | pmid = 9454751 | doi = }}
  • {{cite journal | vauthors = Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T | title = Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31 | journal = The EMBO Journal | volume = 18 | issue = 7 | pages = 1923–38 | date = Apr 1999 | pmid = 10202156 | pmc = 1171278 | doi = 10.1093/emboj/18.7.1923 }}
  • {{cite journal | vauthors = Minc E, Allory Y, Worman HJ, Courvalin JC, Buendia B | title = Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells | journal = Chromosoma | volume = 108 | issue = 4 | pages = 220–34 | date = Aug 1999 | pmid = 10460410 | doi = 10.1007/s004120050372 }}
  • {{cite journal | vauthors = Murzina N, Verreault A, Laue E, Stillman B | title = Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins | journal = Molecular Cell | volume = 4 | issue = 4 | pages = 529–40 | date = Oct 1999 | pmid = 10549285 | doi = 10.1016/S1097-2765(00)80204-X }}
  • {{cite journal | vauthors = Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, Chambon P, Losson R | title = Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family | journal = The EMBO Journal | volume = 18 | issue = 22 | pages = 6385–95 | date = Nov 1999 | pmid = 10562550 | pmc = 1171701 | doi = 10.1093/emboj/18.22.6385 }}
  • {{cite journal | vauthors = Brasher SV, Smith BO, Fogh RH, Nietlispach D, Thiru A, Nielsen PR, Broadhurst RW, Ball LJ, Murzina NV, Laue ED | title = The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer | journal = The EMBO Journal | volume = 19 | issue = 7 | pages = 1587–97 | date = Apr 2000 | pmid = 10747027 | pmc = 310228 | doi = 10.1093/emboj/19.7.1587 }}
  • {{cite journal | vauthors = Zhao T, Heyduk T, Allis CD, Eissenberg JC | title = Heterochromatin protein 1 binds to nucleosomes and DNA in vitro | journal = The Journal of Biological Chemistry | volume = 275 | issue = 36 | pages = 28332–8 | date = Sep 2000 | pmid = 10882726 | doi = 10.1074/jbc.M003493200 }}
  • {{cite journal | vauthors = Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T | title = Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins | journal = Nature | volume = 410 | issue = 6824 | pages = 116–20 | date = Mar 2001 | pmid = 11242053 | doi = 10.1038/35065132 }}
  • {{cite journal | vauthors = Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T | title = Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain | journal = Nature | volume = 410 | issue = 6824 | pages = 120–4 | date = Mar 2001 | pmid = 11242054 | doi = 10.1038/35065138 }}
  • {{cite journal | vauthors = Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R | title = Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins | journal = Molecular Cell | volume = 7 | issue = 4 | pages = 729–39 | date = Apr 2001 | pmid = 11336697 | doi = 10.1016/S1097-2765(01)00218-0 }}
  • {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
  • {{cite journal | vauthors = Scholzen T, Endl E, Wohlenberg C, van der Sar S, Cowell IG, Gerdes J, Singh PB | title = The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure | journal = The Journal of Pathology | volume = 196 | issue = 2 | pages = 135–44 | date = Feb 2002 | pmid = 11793364 | doi = 10.1002/path.1016 }}
  • {{cite journal | vauthors = Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV, Laue ED | title = Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 | journal = Nature | volume = 416 | issue = 6876 | pages = 103–7 | date = Mar 2002 | pmid = 11882902 | doi = 10.1038/nature722 }}
  • {{cite journal | vauthors = Vassallo MF, Tanese N | title = Isoform-specific interaction of HP1 with human TAFII130 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 9 | pages = 5919–24 | date = Apr 2002 | pmid = 11959914 | pmc = 122877 | doi = 10.1073/pnas.092025499 }}
  • {{cite journal | vauthors = Hwang KK, Worman HJ | title = Gene regulation by human orthologs of Drosophila heterochromatin protein 1 | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 4 | pages = 1217–22 | date = May 2002 | pmid = 12054505 | doi = 10.1016/S0006-291X(02)00377-7 }}
  • {{cite journal | vauthors = Bhattacharya N, Wang Z, Davitt C, McKenzie IF, Xing PX, Magnuson NS | title = Pim-1 associates with protein complexes necessary for mitosis | journal = Chromosoma | volume = 111 | issue = 2 | pages = 80–95 | date = Jul 2002 | pmid = 12111331 | doi = 10.1007/s00412-002-0192-6 }}
  • {{cite journal | vauthors = Lin CY, Li CC, Huang PH, Lee FJ | title = A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1 | journal = Journal of Cell Science | volume = 115 | issue = Pt 23 | pages = 4433–45 | date = Dec 2002 | pmid = 12414990 | doi = 10.1242/jcs.00123 }}
  • {{cite journal | vauthors = Festenstein R, Pagakis SN, Hiragami K, Lyon D, Verreault A, Sekkali B, Kioussis D | title = Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells | journal = Science | volume = 299 | issue = 5607 | pages = 719–21 | date = Jan 2003 | pmid = 12560554 | doi = 10.1126/science.1078694 }}
{{refend}}

External links

  • {{MeshName|CBX1+protein,+human}}
  • {{UCSC gene info|CBX1}}
{{NLM content}}{{PDB Gallery|geneid=10951}}{{Transcription factors}}

2 : Transcription factors|Genes mutated in mice
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