| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.[1][2]At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[2] InteractionsCBX3 has been shown to interact with PIM1,[3] Ki-67,[4] Lamin B receptor,[5] CBX5[6] and CBX1.[6] See also- Heterochromatin protein 1
References1. ^{{cite journal | vauthors = Ye Q, Worman HJ | title = Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 | journal = J Biol Chem | volume = 271 | issue = 25 | pages = 14653–6 |date=August 1996 | pmid = 8663349 | pmc = | doi =10.1074/jbc.271.25.14653 }}
2. ^1 {{cite web | title = Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11335| accessdate = }}
3. ^{{cite journal |last=Koike |first=N |author2=Maita H|author3=Taira T|author4=Ariga H|author5=Iguchi-Ariga S M |date=February 2000 |title=Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1) |journal=FEBS Lett. |volume=467 |issue=1 |pages=17–21 | issn = 0014-5793| pmid = 10664448 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(00)01105-4 }}
4. ^{{cite journal |last=Kametaka |first=Ai |author2=Takagi Masatoshi |author3=Hayakawa Tomohiro |author4=Haraguchi Tokuko |author5=Hiraoka Yasushi |author6=Yoneda Yoshihiro |date=December 2002 |title=Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins |journal=Genes Cells |volume=7 |issue=12 |pages=1231–42 | issn = 1356-9597| pmid = 12485163 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1365-2443.2002.00596.x }}
5. ^{{cite journal |last=Ye |first=Q |author2=Worman H J |date=June 1996 |title=Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 |journal=J. Biol. Chem. |volume=271 |issue=25 |pages=14653–6 | issn = 0021-9258| pmid = 8663349 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.25.14653 }}
6. ^1 {{cite journal |last=Nielsen |first=A L |author2=Oulad-Abdelghani M|author3=Ortiz J A|author4=Remboutsika E|author5=Chambon P|author6=Losson R |date=April 2001 |title=Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins |journal=Mol. Cell |volume=7 |issue=4 |pages=729–39 | issn = 1097-2765| pmid = 11336697 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(01)00218-0 }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Ye Q, Callebaut I, Pezhman A |title=Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14983–9 |year= 1997 |pmid= 9169472 |doi=10.1074/jbc.272.23.14983 |display-authors=etal}}
- {{cite journal | vauthors=Lessard J, Baban S, Sauvageau G |title=Stage-specific expression of polycomb group genes in human bone marrow cells |journal=Blood |volume=91 |issue= 4 |pages= 1216–24 |year= 1998 |pmid= 9454751 |doi= }}
- {{cite journal | vauthors=Seeler JS, Marchio A, Sitterlin D |title=Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 13 |pages= 7316–21 |year= 1998 |pmid= 9636146 |doi=10.1073/pnas.95.13.7316 | pmc=22602 |display-authors=etal|bibcode=1998PNAS...95.7316S}}
- {{cite journal | vauthors=Lehming N, Le Saux A, Schüller J, Ptashne M |title=Chromatin components as part of a putative transcriptional repressing complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 13 |pages= 7322–6 |year= 1998 |pmid= 9636147 |doi=10.1073/pnas.95.13.7322 | pmc=22604 |bibcode=1998PNAS...95.7322L }}
- {{cite journal | vauthors=Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC |title=INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1 |journal=J. Cell Biol. |volume=143 |issue= 7 |pages= 1763–74 |year= 1999 |pmid= 9864353 |doi=10.1083/jcb.143.7.1763 | pmc=2175214 }}
- {{cite journal | vauthors=Ryan RF, Schultz DC, Ayyanathan K |title=KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4366–78 |year= 1999 |pmid= 10330177 |doi= 10.1128/mcb.19.6.4366| pmc=104396 |display-authors=etal}}
- {{cite journal | vauthors=Minc E, Allory Y, Worman HJ |title=Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells |journal=Chromosoma |volume=108 |issue= 4 |pages= 220–34 |year= 1999 |pmid= 10460410 |doi=10.1007/s004120050372 |display-authors=etal}}
- {{cite journal | vauthors=Nielsen AL, Ortiz JA, You J |title=Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family |journal=EMBO J. |volume=18 |issue= 22 |pages= 6385–95 |year= 2000 |pmid= 10562550 |doi= 10.1093/emboj/18.22.6385 | pmc=1171701 |display-authors=etal}}
- {{cite journal | vauthors=Koike N, Maita H, Taira T |title=Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1) |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 17–21 |year= 2000 |pmid= 10664448 |doi=10.1016/S0014-5793(00)01105-4 |display-authors=etal}}
- {{cite journal | vauthors=Minc E, Courvalin JC, Buendia B |title=HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 279–84 |year= 2001 |pmid= 11124534 |doi=10.1159/000056789 }}
- {{cite journal | vauthors=Lachner M, O'Carroll D, Rea S |title=Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins |journal=Nature |volume=410 |issue= 6824 |pages= 116–20 |year= 2001 |pmid= 11242053 |doi= 10.1038/35065132 |display-authors=etal}}
- {{cite journal | vauthors=Nielsen AL, Oulad-Abdelghani M, Ortiz JA |title=Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins |journal=Mol. Cell |volume=7 |issue= 4 |pages= 729–39 |year= 2001 |pmid= 11336697 |doi=10.1016/S1097-2765(01)00218-0 |display-authors=etal}}
- {{cite journal | vauthors=Scholzen T, Endl E, Wohlenberg C |title=The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure |journal=J. Pathol. |volume=196 |issue= 2 |pages= 135–44 |year= 2002 |pmid= 11793364 |doi= 10.1002/path.1016 |display-authors=etal}}
- {{cite journal | vauthors=Vassallo MF, Tanese N |title=Isoform-specific interaction of HP1 with human TAFII130 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 9 |pages= 5919–24 |year= 2002 |pmid= 11959914 |doi= 10.1073/pnas.092025499 | pmc=122877 |bibcode=2002PNAS...99.5919V }}
- {{cite journal | vauthors=Ogawa H, Ishiguro K, Gaubatz S |title=A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells |journal=Science |volume=296 |issue= 5570 |pages= 1132–6 |year= 2002 |pmid= 12004135 |doi= 10.1126/science.1069861 |display-authors=etal|bibcode=2002Sci...296.1132O }}
- {{cite journal | vauthors=Hwang KK, Worman HJ |title=Gene regulation by human orthologs of Drosophila heterochromatin protein 1 |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 4 |pages= 1217–22 |year= 2002 |pmid= 12054505 |doi= 10.1016/S0006-291X(02)00377-7 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Kametaka A, Takagi M, Hayakawa T |title=Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins |journal=Genes Cells |volume=7 |issue= 12 |pages= 1231–42 |year= 2003 |pmid= 12485163 |doi=10.1046/j.1365-2443.2002.00596.x |display-authors=etal}}
- {{cite journal | vauthors=Cheutin T, McNairn AJ, Jenuwein T |title=Maintenance of stable heterochromatin domains by dynamic HP1 binding |journal=Science |volume=299 |issue= 5607 |pages= 721–5 |year= 2003 |pmid= 12560555 |doi= 10.1126/science.1078572 |display-authors=etal|bibcode=2003Sci...299..721C }}
{{refend}} External links - {{MeshName|CBX3+protein,+human}}
- {{UCSC gene info|CBX3}}
{{NLM content}}{{Transcription factors}} 1 : Transcription factors |