“C-C chemokine receptor type 7”的意思、由来-开放百科全书

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen.^[3]

Activation of Dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.^[4]

Clinical significance

CCR7 is expressed by various cancer cells, such as nonsmall lung cancer, gastric cancer and oesophageal cancer.^[5]^[6]^[7] Expression of CCR7 by cancer cells is linked with metastasis to lymph nodes.^[8]

References

1. ^{{cite journal | vauthors = Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E | title = Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors | journal = Journal of Virology | volume = 67 | issue = 4 | pages = 2209–20 | date = Apr 1993 | pmid = 8383238 | pmc = 240341 | doi = }}
2. ^F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
3. ^{{cite journal | vauthors = Sharma N, Benechet AP, Lefrançois L, Khanna KM | title = CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues| journal = Journal of Immunology | volume = 195 | issue = 11 | pages = 5227–5236 | date = Dec 2015 | pmid = 26500349 | doi=10.4049/jimmunol.1500993| pmc = 4655190 }}
4. ^{{cite journal | vauthors = Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL | title = The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed | journal = Journal of Immunology | volume = 174 | issue = 7 | pages = 4070–80 | date = Apr 2005 | pmid = 15778365 | doi=10.4049/jimmunol.174.7.4070}}
5. ^{{cite journal | vauthors = Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K, Inoue H, Mori M | title = Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma | journal = Cancer Research | volume = 62 | issue = 10 | pages = 2937–41 | date = May 2002 | pmid = 12019175 }}
6. ^{{cite journal | vauthors = Takanami I | title = Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis | journal = International Journal of Cancer | volume = 105 | issue = 2 | pages = 186–9 | date = Jun 2003 | pmid = 12673677 | doi = 10.1002/ijc.11063 }}
7. ^{{cite journal | vauthors = Ding Y, Shimada Y, Maeda M, Kawabe A, Kaganoi J, Komoto I, Hashimoto Y, Miyake M, Hashida H, Imamura M | title = Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma | journal = Clinical Cancer Research | volume = 9 | issue = 9 | pages = 3406–12 | date = Aug 2003 | pmid = 12960129 }}
8. ^{{cite journal | vauthors = Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA | title = Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling | journal = Cancer Cell | volume = 11 | issue = 6 | pages = 526–38 | date = Jun 2007 | pmid = 17560334 | doi = 10.1016/j.ccr.2007.04.020 }}

Further reading

{{cite journal | vauthors = Müller G, Lipp M | title = Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking | journal = Microcirculation | volume = 10 | issue = 3–4 | pages = 325–34 | date = Jun 2003 | pmid = 12851649 | doi = 10.1038/sj.mn.7800197 }}

{{cite journal | vauthors = Burgstahler R, Kempkes B, Steube K, Lipp M | title = Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2 | journal = Biochemical and Biophysical Research Communications | volume = 215 | issue = 2 | pages = 737–43 | date = Oct 1995 | pmid = 7488016 | doi = 10.1006/bbrc.1995.2525 }}

{{cite journal | vauthors = Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy RL, Shows TB, Gray PW | title = Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2 | journal = Genomics | volume = 23 | issue = 3 | pages = 643–50 | date = Oct 1994 | pmid = 7851893 | doi = 10.1006/geno.1994.1553 }}

{{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}

{{cite journal | vauthors = Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 21 | pages = 13803–9 | date = May 1997 | pmid = 9153236 | doi = 10.1074/jbc.272.21.13803 }}

{{cite journal | vauthors = Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O | title = Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 7118–22 | date = Mar 1998 | pmid = 9507024 | doi = 10.1074/jbc.273.12.7118 }}

{{cite journal | vauthors = Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC | title = 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7 | journal = The Journal of Cell Biology | volume = 141 | issue = 4 | pages = 1053–9 | date = May 1998 | pmid = 9585422 | pmc = 2132769 | doi = 10.1083/jcb.141.4.1053 }}

{{cite journal | vauthors = Kim CH, Pelus LM, White JR, Broxmeyer HE | title = Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells | journal = Journal of Immunology | volume = 161 | issue = 5 | pages = 2580–5 | date = Sep 1998 | pmid = 9725259 | doi = }}

{{cite journal | vauthors = Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y | title = EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation | journal = Journal of Immunology | volume = 161 | issue = 6 | pages = 3096–102 | date = Sep 1998 | pmid = 9743376 | doi = }}

{{cite journal | vauthors = Hasegawa H, Nomura T, Kohno M, Tateishi N, Suzuki Y, Maeda N, Fujisawa R, Yoshie O, Fujita S | title = Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells | journal = Blood | volume = 95 | issue = 1 | pages = 30–8 | date = Jan 2000 | pmid = 10607681 | doi = }}

{{cite journal | vauthors = Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ | title = Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK | journal = Journal of Immunology | volume = 164 | issue = 6 | pages = 2851–6 | date = Mar 2000 | pmid = 10706668 | doi = 10.4049/jimmunol.164.6.2851 }}

{{cite journal | vauthors = Agace WW, Roberts AI, Wu L, Greineder C, Ebert EC, Parker CM | title = Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation | journal = European Journal of Immunology | volume = 30 | issue = 3 | pages = 819–26 | date = Mar 2000 | pmid = 10741397 | doi = 10.1002/1521-4141(200003)30:3<819::AID-IMMU819>3.0.CO;2-Y }}

{{cite journal | vauthors = Annunziato F, Romagnani P, Cosmi L, Beltrame C, Steiner BH, Lazzeri E, Raport CJ, Galli G, Manetti R, Mavilia C, Vanini V, Chantry D, Maggi E, Romagnani S | title = Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection | journal = Journal of Immunology | volume = 165 | issue = 1 | pages = 238–46 | date = Jul 2000 | pmid = 10861057 | doi = 10.4049/jimmunol.165.1.238 }}

{{cite journal | vauthors = Campbell JJ, Murphy KE, Kunkel EJ, Brightling CE, Soler D, Shen Z, Boisvert J, Greenberg HB, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Butcher EC, Wu L | title = CCR7 expression and memory T cell diversity in humans | journal = Journal of Immunology | volume = 166 | issue = 2 | pages = 877–84 | date = Jan 2001 | pmid = 11145663 | doi = 10.4049/jimmunol.166.2.877}}

{{cite journal | vauthors = Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, Wu L, Butcher EC | title = Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire | journal = Journal of Immunology | volume = 166 | issue = 11 | pages = 6477–82 | date = Jun 2001 | pmid = 11359797 | doi = 10.4049/jimmunol.166.11.6477 }}

{{cite journal | vauthors = Taylor JR, Kimbrell KC, Scoggins R, Delaney M, Wu L, Camerini D | title = Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1 | journal = Journal of Virology | volume = 75 | issue = 18 | pages = 8752–60 | date = Sep 2001 | pmid = 11507220 | pmc = 115120 | doi = 10.1128/JVI.75.18.8752-8760.2001 }}

{{cite journal | vauthors = Höpken UE, Foss HD, Meyer D, Hinz M, Leder K, Stein H, Lipp M | title = Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs | journal = Blood | volume = 99 | issue = 4 | pages = 1109–16 | date = Feb 2002 | pmid = 11830455 | doi = 10.1182/blood.V99.4.1109 }}

{{cite journal | vauthors = Nakayama T, Fujisawa R, Izawa D, Hieshima K, Takada K, Yoshie O | title = Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5 | journal = Journal of Virology | volume = 76 | issue = 6 | pages = 3072–7 | date = Mar 2002 | pmid = 11861876 | pmc = 135988 | doi = 10.1128/JVI.76.6.3072-3077.2002 }}

{{cite journal | vauthors = Till KJ, Lin K, Zuzel M, Cawley JC | title = The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes | journal = Blood | volume = 99 | issue = 8 | pages = 2977–84 | date = Apr 2002 | pmid = 11929789 | doi = 10.1182/blood.V99.8.2977 }}

{{cite journal | vauthors = Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, García-Bordas J, Martín D, Longo N, Cuadrado A, Cabañas C, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL | title = Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells | journal = Blood | volume = 104 | issue = 3 | pages = 619–25 | date = Aug 2004 | pmid = 15059845 | doi = 10.1182/blood-2003-11-3943 }}

{{cite journal | vauthors = López-Cotarelo P, Escribano-Díaz C, González-Bethencourt IL, Gómez-Moreira C, Deguiz ML, Torres-Bacete J, Gómez-Cabañas L, Fernández-Barrera J, Delgado-Martín C, Mellado M, Regueiro JR, Miranda-Carús ME, Rodríguez-Fernández JL | title = A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. | journal = J Biol Chem | volume = 290 | issue = 2 | pages = 827–40 | date = November 2014 | pmid = 25425646 | pmc = 4294505 | doi = 10.1038/nprot.2014.078 }}

{{cite journal | vauthors = Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL | title = The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed | journal = Journal of Immunology | volume = 174 | issue = 7 | pages = 4070–80 | date = Apr 2005 | pmid = 15778365 | doi = 10.4049/jimmunol.174.7.4070 }}

{{cite journal | vauthors = Torres-Bacete J, Delgado-Martín C, Gómez-Moreira C, Simizu S, Rodríguez-Fernández JL | title = The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells | journal = Journal of Immunology | volume = 195 | issue = 3 | pages = 973–81 | date = Jun 2015 | pmid = 25425646 | doi = 10.1074/jbc.M114.59655 | doi-broken-date = 2019-02-12 }}

{{cite journal | vauthors = Sánchez-Sánchez N, Riol-Blanco L, Rodríguez-Fernández JL | title = The multiple personalities of the chemokine receptor CCR7 in dendritic cells | journal = Journal of Immunology | volume = 176 | issue = 9 | pages = 5153–9 | date = May 2006 | pmid = 16621978 | doi = 10.4049/jimmunol.176.9.5153 }}

{{cite journal | vauthors = Escribano C, Delgado-Martín C, Rodríguez-Fernández JL | title = CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta | journal = Journal of Immunology | volume = 183 | issue = 10 | pages = 6282–95 | date = Nov 2009 | pmid = 19841191 | doi = 10.4049/jimmunol.0804093 }}

2 : Chemokine receptors|Clusters of differentiation

Function

Clinical significance

References

External links

Further reading