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词条 CCL17
释义

  1. References

  2. Further reading

  3. External links

{{Infobox_gene}}Chemokine (C-C motif) ligand 17 (CCL17) (also known as TARC) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.[1] This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.[1][2] The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.[3][4]

References

1. ^1 {{cite journal | vauthors = Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O | title = Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector | journal = J. Biol. Chem. | volume = 271 | issue = 35 | pages = 21514–21 | year = 1996 | pmid = 8702936 | doi = 10.1074/jbc.271.35.21514 }}
2. ^{{cite journal | vauthors = Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O | title = The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 | journal = J. Biol. Chem. | volume = 272 | issue = 23 | pages = 15036–42 | year = 1997 | pmid = 9169480 | doi = 10.1074/jbc.272.23.15036 }}
3. ^{{cite journal | vauthors = Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O | title = Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13 | journal = Genomics | volume = 40 | issue = 1 | pages = 211–3 | year = 1997 | pmid = 9070951 | doi = 10.1006/geno.1996.4552 }}
4. ^{{cite journal | vauthors = Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O | title = Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13 | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 1 | pages = 10–1 | year = 1998 | pmid = 9691168 | doi = 10.1159/000015000 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Saeki H, Tamaki K |title=Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. |journal=J. Dermatol. Sci. |volume=43 |issue= 2 |pages= 75–84 |year= 2006 |pmid= 16859899 |doi= 10.1016/j.jdermsci.2006.06.002 }}
  • {{cite journal | vauthors=Imai T, Yoshida T, Baba M |title=Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21514–21 |year= 1996 |pmid= 8702936 |doi=10.1074/jbc.271.35.21514 |display-authors=etal}}
  • {{cite journal | vauthors=Nomiyama H, Imai T, Kusuda J |title=Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13. |journal=Genomics |volume=40 |issue= 1 |pages= 211–3 |year= 1997 |pmid= 9070951 |doi= 10.1006/geno.1996.4552 |display-authors=etal}}
  • {{cite journal | vauthors=Imai T, Baba M, Nishimura M |title=The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 15036–42 |year= 1997 |pmid= 9169480 |doi=10.1074/jbc.272.23.15036 |display-authors=etal}}
  • {{cite journal | vauthors=Imai T, Chantry D, Raport CJ |title=Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1764–8 |year= 1998 |pmid= 9430724 |doi=10.1074/jbc.273.3.1764 |display-authors=etal}}
  • {{cite journal | vauthors=Bernardini G, Hedrick J, Sozzani S |title=Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. |journal=Eur. J. Immunol. |volume=28 |issue= 2 |pages= 582–8 |year= 1998 |pmid= 9521068 |doi=10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A |display-authors=etal}}
  • {{cite journal | vauthors=Nomiyama H, Imai T, Kusuda J |title=Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 1 |pages= 10–1 |year= 1998 |pmid= 9691168 |doi=10.1159/000015000 |display-authors=etal}}
  • {{cite journal | vauthors=Struyf S, Proost P, Sozzani S |title=Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. |journal=J. Immunol. |volume=161 |issue= 6 |pages= 2672–5 |year= 1998 |pmid= 9743322 |doi= |display-authors=etal}}
  • {{cite journal | vauthors=Loftus BJ, Kim UJ, Sneddon VP |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 |display-authors=etal}}
  • {{cite journal | vauthors=Garlisi CG, Xiao H, Tian F |title=The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3210–5 |year= 1999 |pmid= 10540332 |doi=10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W |display-authors=etal}}
  • {{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |display-authors=etal}}
  • {{cite journal | vauthors=Ghia P, Transidico P, Veiga JP |title=Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells |journal=Blood |volume=98 |issue= 3 |pages= 533–40 |year= 2001 |pmid= 11468146 |doi=10.1182/blood.V98.3.533 |display-authors=etal}}
  • {{cite journal | vauthors=Morita A, Kikuoka S, Horikawa T |title=Evaluation of human thymus and activation-regulated chemokine concentrations in blood using a new sandwich ELISA based on monoclonal antibodies |journal=Clin. Chim. Acta |volume=322 |issue= 1–2 |pages= 67–75 |year= 2002 |pmid= 12104083 |doi=10.1016/S0009-8981(02)00131-6 |display-authors=etal}}
  • {{cite journal | vauthors=Basu S, Schaefer TM, Ghosh M |title=Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines |journal=Cytokine |volume=18 |issue= 3 |pages= 140–8 |year= 2003 |pmid= 12126650 |doi=10.1006/cyto.2002.0875 |display-authors=etal}}
  • {{cite journal | vauthors=D'Ambrosio D, Albanesi C, Lang R |title=Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2303–12 |year= 2002 |pmid= 12193695 |doi= 10.4049/jimmunol.169.5.2303|display-authors=etal}}
  • {{cite journal | vauthors=Matsumoto N, Mukae H, Nakamura-Uchiyama F |title=Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani |journal=Clin. Exp. Immunol. |volume=130 |issue= 2 |pages= 314–8 |year= 2002 |pmid= 12390321 |doi=10.1046/j.1365-2249.2002.01985.x | pmc=1906524 |display-authors=etal}}
  • {{cite journal | vauthors=Zheng X, Nakamura K, Tojo M |title=TGF-beta1-mediated regulation of thymus and activation-regulated chemokine (TARC/CCL17) synthesis and secretion by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma |journal=J. Dermatol. Sci. |volume=30 |issue= 2 |pages= 154–60 |year= 2003 |pmid= 12413771 |doi=10.1016/S0923-1811(02)00071-3 |display-authors=etal}}
  • {{cite journal | vauthors=Kakinuma T, Nakamura K, Wakugawa M |title=IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line |journal=Cytokine |volume=20 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12441140 |doi=10.1006/cyto.2002.1965 |display-authors=etal}}
  • {{cite journal | vauthors=Uchida T, Suto H, Ra C |title=Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis |journal=Int. Immunol. |volume=14 |issue= 12 |pages= 1431–8 |year= 2003 |pmid= 12456591 |doi=10.1093/intimm/dxf109 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal|last1=Jones|first1=K|title=Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma.|journal=Clin Cancer Res|date=Feb 1, 2013|volume=19|issue=3|pages=731–42|pmid=23224400|doi=10.1158/1078-0432.CCR-12-2693}}
{{refend}}

External links

  • {{UCSC gene info|CCL17}}
{{PDB Gallery|geneid=6361}}{{Chemokines}}{{Chemokine receptor modulators}}{{gene-16-stub}}

1 : Cytokines
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