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词条 CCL5
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. External links

  6. Further reading

{{Infobox_gene}}

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene.[1] It is also known as RANTES (regulated on activation, normal T cell expressed and secreted).

Function

CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[2] It is also an HIV-suppressive factor released from CD8+ T cells{{Citation needed|reason=Your explanation here|date=September 2017}}. This chemokine has been localized to chromosome 17 in humans.[1]

RANTES was first identified in a search for genes expressed "late" (3–5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13).[3][4][5][6] RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells.[7] Recently, the RANTES protein has been engineered for in vivo production by Lactobacillus bacteria, and this solution is being developed into a possible HIV entry-inhibiting topical microbicide.[8]

Interactions

CCL5 has been shown to interact with CCR3, [9] [10] CCR5[10][11][12] and CCR1.[10][12]

CCL5 also activates the G-protein coupled receptor GPR75. [13]

See also

  • Chemotaxis
  • Chemokine

References

1. ^1 {{cite journal | vauthors = Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C | title = Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12 | journal = Genomics | volume = 6 | issue = 3 | pages = 548–53 | date = March 1990 | pmid = 1691736 | doi = 10.1016/0888-7543(90)90485-D | url = }}
2. ^{{cite journal | vauthors = Maghazachi AA, Al-Aoukaty A, Schall TJ | title = CC chemokines induce the generation of killer cells from CD56+ cells | journal = Eur. J. Immunol. | volume = 26 | issue = 2 | pages = 315–9 | date = February 1996 | pmid = 8617297 | doi = 10.1002/eji.1830260207 | url = | issn = }}
3. ^{{cite journal | vauthors = Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM | title = A human T cell-specific molecule is a member of a new gene family | journal = J. Immunol. | volume = 141 | issue = 3 | pages = 1018–25 | date = August 1988 | pmid = 2456327 | doi = | url = http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2456327 | issn = }}
4. ^{{cite book | author = Alan M. Krensky | others = | title = Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit) | edition = | language = | publisher = R G Landes Co. | location = | year = 1995 | origyear = | pages = | quote = | isbn = 978-1-57059-253-9 | oclc = | doi = | url = | accessdate = }}
5. ^{{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = January 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 | url = }}
6. ^{{cite journal | vauthors = Song A, Nikolcheva T, Krensky AM | title = Transcriptional regulation of RANTES expression in T lymphocytes | journal = Immunol. Rev. | volume = 177 | issue = | pages = 236–45 | date = October 2000 | pmid = 11138780 | doi = 10.1034/j.1600-065X.2000.17610.x | url = }}
7. ^{{cite journal | vauthors = Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P | title = Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells | journal = Science | volume = 270 | issue = 5243 | pages = 1811–5 | date = December 1995 | pmid = 8525373 | doi = 10.1126/science.270.5243.1811 | url = http://www.sciencemag.org/cgi/reprint/270/5243/1811 | issn = }}
8. ^{{cite journal | vauthors = Vangelista L, Secchi M, Liu X, Bachi A, Jia L, Xu Q, Lusso P | title = Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers | journal = Antimicrob. Agents Chemother. | volume = 54 | issue = 7 | pages = 2994–3001 | date = July 2010 | pmid = 20479208 | pmc = 2897324 | doi = 10.1128/AAC.01492-09 | laysummary = https://www.sciencedaily.com/releases/2010/07/100721153305.htm | laysource = Science Daily }}
9. ^{{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | date = May 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 | url = | issn = }}
10. ^1 2 {{cite journal | vauthors = Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J | title = Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils | journal = Eur. J. Immunol. | volume = 31 | issue = 7 | pages = 2170–8 | date = July 2001 | pmid = 11449371 | doi = 10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D | url = | issn = }}
11. ^{{cite journal | vauthors = Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L | title = Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages | journal = Biochim. Biophys. Acta | volume = 1617 | issue = 1–2 | pages = 80–8 | date = October 2003 | pmid = 14637022 | doi = 10.1016/j.bbamem.2003.09.006 | url = | issn = }}
12. ^1 {{cite journal | vauthors = Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN | title = The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity | journal = J. Biol. Chem. | volume = 276 | issue = 14 | pages = 10620–6 | date = April 2001 | pmid = 11116158 | doi = 10.1074/jbc.M010867200 | url = | issn = }}
13. ^{{cite journal | vauthors = Ignatov A, Robert J, Gregory-Evans C, Schaller HC | title = RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 | journal = Br. J. Pharmacol. | volume = 149 | issue = 5 | pages = 490–7 | date = November 2006 | pmid = 17001303 | pmc = 2014681 | doi = 10.1038/sj.bjp.0706909 | url = | issn = }}

External links

  • {{UCSC gene info|CCL5}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB | title = HIV-1 Vpr and anti-inflammatory activity. | journal = DNA Cell Biol. | volume = 23 | issue = 4 | pages = 239–47 | year = 2004 | pmid = 15142381 | doi = 10.1089/104454904773819824 }}
  • {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation. | journal = Cell Res. | volume = 15 | issue = 3 | pages = 143–9 | year = 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}
  • {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses. | journal = Indian J. Med. Res. | volume = 121 | issue = 4 | pages = 270–86 | year = 2005 | pmid = 15817944 | doi = }}
  • {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Res. | volume = 15 | issue = 11–12 | pages = 923–34 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 }}
  • {{cite journal | vauthors = Ignatov A, Robert J, Gregory-Evans C, Schaller HC | title = RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 | journal = Br J Pharmacol | volume = 149 | issue = 5 | pages = 490–7 | date = Nov 2006 | pmid = 17001303 | pmc = 2014681 | doi = 10.1038/sj.bjp.0706909 | url = }}
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