“CDC25C”的意思、由来-开放百科全书

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.^[2]

Interactions

CDC25C has been shown to interact with MAPK14,^[3] CHEK1,^[4] PCNA,^[5] PIN1,^[6]^[7]^[8] PLK3^[9] and NEDD4.^[8]

See also

References

1. ^{{cite journal | vauthors = Gould KL, Moreno S, Tonks NK, Nurse P | title = Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase | journal = Science | volume = 250 | issue = 4987 | pages = 1573–6 |date=Feb 1991 | pmid = 1703321 | pmc = | doi =10.1126/science.1703321 | bibcode =1990Sci...250.1573G }}
2. ^{{cite web | title = Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=995| accessdate = }}
3. ^{{cite journal |last=Bulavin |first=D V |author2=Higashimoto Y|author3=Popoff I J|author4=Gaarde W A|author5=Basrur V|author6=Potapova O|author7=Appella E|author8=Fornace A J |date=May 2001 |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase |journal=Nature |volume=411 |issue=6833 |pages=102–7 |publisher= |location = England| issn = 0028-0836| pmid = 11333986 |doi = 10.1038/35075107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
4. ^{{cite journal |last=Sanchez |first=Y |author2=Wong C|author3=Thoma R S|author4=Richman R|author5=Wu Z|author6=Piwnica-Worms H|author7=Elledge S J |date=Sep 1997 |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=Science |volume=277 |issue=5331 |pages=1497–501 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9278511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.277.5331.1497 }}
5. ^{{cite journal |last=Kawabe |first=Takumi |author2=Suganuma Masashi |author3=Ando Tomoaki |author4=Kimura Mayumi |author5=Hori Haruna |author6=Okamoto Takashi |date=Mar 2002 |title=Cdc25C interacts with PCNA at G2/M transition |journal=Oncogene |volume=21 |issue=11 |pages=1717–26 |publisher= |location = England| issn = 0950-9232| pmid = 11896603 |doi = 10.1038/sj.onc.1205229 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
6. ^{{cite journal |last=Shen |first=M |author2=Stukenberg P T|author3=Kirschner M W|author4=Lu K P |date=Mar 1998 |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins |journal=Genes Dev. |volume=12 |issue=5 |pages=706–20 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9499405 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1101/gad.12.5.706 | pmc = 316589 }}
7. ^{{cite journal |last=Goldstrohm |first=A C |author2=Albrecht T R|author3=Suñé C|author4=Bedford M T|author5=Garcia-Blanco M A |date=Nov 2001 |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue=22 |pages=7617–28 |publisher= |location = United States| issn = 0270-7306| pmid = 11604498 |doi = 10.1128/MCB.21.22.7617-7628.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 99933 }}
8. ^¹{{cite journal |last=Lu |first=P J |author2=Zhou X Z|author3=Shen M|author4=Lu K P |date=Feb 1999 |title=Function of WW domains as phosphoserine- or phosphothreonine-binding modules |journal=Science |volume=283 |issue=5406 |pages=1325–8 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 10037602 | bibcode =1999Sci...283.1325L | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.283.5406.1325 }}
9. ^{{cite journal |last=Ouyang |first=B |author2=Li W|author3=Pan H|author4=Meadows J|author5=Hoffmann I|author6=Dai W |date=Oct 1999 |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk |journal=Oncogene |volume=18 |issue=44 |pages=6029–36 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10557092 |doi = 10.1038/sj.onc.1202983 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}

Further reading

{{cite journal | vauthors=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53–63 |year= 1997 |pmid= 9141461 |doi= 10.1016/S0304-419X(96)00049-2}}

{{cite journal | vauthors=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue= |pages= 107–14 |year= 2000 |pmid= 10740819 |doi= 10.1007/978-1-4615-4253-7_10}}

{{cite journal | vauthors=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249–60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833 }}

{{cite journal | vauthors=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 |bibcode=2004NYASA1024..153K }}

{{cite journal | vauthors=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988 }}

{{cite journal | author=Sartor H |title=Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively |journal=Genomics |volume=13 |issue= 3 |pages= 911–2 |year= 1992 |pmid= 1386342 |doi=10.1016/0888-7543(92)90190-4 |name-list-format=vanc| author2=Ehlert F | author3=Grzeschik KH | display-authors=3 | last4=Mu¨Ller | first4=Rolf | last5=Adolph | first5=Sabine }}

{{cite journal | author=Strausfeld U |title=Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein |journal=Nature |volume=351 |issue= 6323 |pages= 242–5 |year= 1991 |pmid= 1828290 |doi= 10.1038/351242a0 |name-list-format=vanc| author2=Labbé JC | author3=Fesquet D | display-authors=3 | last4=Cavadore | first4=J. C. | last5=Picard | first5=A. | last6=Sadhu | first6=K. | last7=Russell | first7=P. | last8=Dorée | first8=M. |bibcode=1991Natur.351..242S}}

{{cite journal | vauthors=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins |journal=Cell |volume=67 |issue= 6 |pages= 1181–94 |year= 1992 |pmid= 1836978 |doi=10.1016/0092-8674(91)90294-9 }}

{{cite journal | vauthors=Sadhu K, Reed SI, Richardson H, Russell P |title=Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5139–43 |year= 1990 |pmid= 2195549 |doi=10.1073/pnas.87.13.5139 | pmc=54277 |bibcode=1990PNAS...87.5139S }}

{{cite journal | vauthors=Re F, Braaten D, Franke EK, Luban J |title=Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B |journal=J. Virol. |volume=69 |issue= 11 |pages= 6859–64 |year= 1995 |pmid= 7474100 |doi= | pmc=189600 }}

{{cite journal | author=Zwicker J |title=Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1 |journal=Nucleic Acids Res. |volume=23 |issue= 19 |pages= 3822–30 |year= 1995 |pmid= 7479023 |doi=10.1093/nar/23.19.3822 | pmc=307297 |name-list-format=vanc| author2=Gross C | author3=Lucibello FC | display-authors=3 | last4=Truss | first4=Mathias | last5=Ehiert | first5=Frauke | last6=Engeland | first6=Kurt | last7=Müller | first7=Rolf }}

{{cite journal | author=Di Marzio P |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi= | pmc=189735 |name-list-format=vanc| author2=Choe S | author3=Ebright M | display-authors=3 | last4=Knoblauch | first4=R | last5=Landau | first5=NR }}

{{cite journal | author=Strausfeld U |title=Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 5989–6000 |year= 1994 |pmid= 8119945 |doi= |name-list-format=vanc| author2=Fernandez A | author3=Capony JP | display-authors=3 | last4=Girard | first4=F | last5=Lautredou | first5=N | last6=Derancourt | first6=J | last7=Labbe | first7=JC | last8=Lamb | first8=NJ }}

{{cite journal | vauthors=Zheng XF, Ruderman JV |title=Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25 |journal=Cell |volume=75 |issue= 1 |pages= 155–64 |year= 1993 |pmid= 8402895 |doi= 10.1016/S0092-8674(05)80092-3 }}

{{cite journal | vauthors=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }}

{{cite journal | author=Honda R |title=Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase |journal=FEBS Lett. |volume=318 |issue= 3 |pages= 331–4 |year= 1993 |pmid= 8440392 |doi=10.1016/0014-5793(93)80540-B |name-list-format=vanc| author2=Ohba Y | author3=Nagata A | display-authors=3 | last4=Okayama | first4=H | last5=Yasuda | first5=H }}

{{cite journal | vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300 }}

{{cite journal | author=Sanchez Y |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=Science |volume=277 |issue= 5331 |pages= 1497–501 |year= 1997 |pmid= 9278511 |doi=10.1126/science.277.5331.1497 |name-list-format=vanc| author2=Wong C | author3=Thoma RS | display-authors=3 | last4=Richman | first4=R | last5=Wu | first5=Z | last6=Piwnica-Worms | first6=H | last7=Elledge | first7=SJ }}

Interactions

See also

References

Further reading

External links