| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.[1][2]The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.[3] InteractionsCDC6 has been shown to interact with ORC1L,[2][4] ORC2L,[4][5] Cyclin A2,[2][6] PPP2R3B,[7] MCM3,[5][8] PPP2R3A,[9] MCM7[4][8] and PSKH1.[6] See also- Cdc6 homolog in Saccharomyces cerevisiae
References1. ^{{cite journal | vauthors = Williams RS, Shohet RV, Stillman B | title = A human protein related to yeast Cdc6p | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 1 | pages = 142–7 |date=February 1997 | pmid = 8990175 | pmc = 19260 | doi =10.1073/pnas.94.1.142 }}
2. ^1 2 {{cite journal | vauthors = Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A | title = Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase | journal = Mol Cell Biol | volume = 18 | issue = 5 | pages = 2758–67 |date=May 1998 | pmid = 9566895 | pmc = 110655 | doi = 10.1128/mcb.18.5.2758}}
3. ^{{cite web | title = Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=990| accessdate = }}
4. ^1 2 {{cite journal |doi=10.1016/S0022-2836(03)00079-2 |last=Kneissl |first=Margot |author2=Pütter Vera |author3=Szalay Aladar A |author4=Grummt Friedrich |date=March 2003 |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells |journal=J. Mol. Biol. |volume=327 |issue=1 |pages=111–28 |publisher= |location = England| issn = 0022-2836| pmid = 12614612 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
5. ^1 {{cite journal |doi=10.1128/MCB.20.22.8602-8612.2000 |last=Méndez |first=J |author2=Stillman B |date=November 2000 |title=Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis |journal=Mol. Cell. Biol. |volume=20 |issue=22 |pages=8602–12 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 11046155 |pmc=102165 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
6. ^1 {{cite journal |last=Petersen |first=B O |author2=Lukas J|author3=Sørensen C S|author4=Bartek J|author5=Helin K |date=January 1999 |title=Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization |journal=EMBO J. |volume=18 |issue=2 |pages=396–410 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9889196 |pmc=1171134 |doi = 10.1093/emboj/18.2.396 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |doi=10.1128/MCB.20.3.1021-1029.2000 |last=Yan |first=Z |author2=Fedorov S A|author3=Mumby M C|author4=Williams R S |date=February 2000 |title=PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells |journal=Mol. Cell. Biol. |volume=20 |issue=3 |pages=1021–9 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10629059 |pmc=85219 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
8. ^1 {{cite journal |doi=10.1074/jbc.274.36.25927 |last=Fujita |first=M |author2=Yamada C|author3=Goto H|author4=Yokoyama N|author5=Kuzushima K|author6=Inagaki M|author7=Tsurumi T |date=September 1999 |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation |journal=J. Biol. Chem. |volume=274 |issue=36 |pages=25927–32 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10464337 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
9. ^{{cite journal |last=Davis |first=Anthony J |author2=Yan Zhen |author3=Martinez Bobbie |author4=Mumby Marc C |date=June 2008 |title=Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit |journal=J. Biol. Chem. |volume=283 |issue=23 |pages=16104–14 |publisher= |location = United States| issn = 0021-9258| pmid = 18397887 |pmc=2414307 |doi = 10.1074/jbc.M710313200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Yan Z, DeGregori J, Shohet R |title=Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3603–8 |year= 1998 |pmid= 9520412 | pmc=19882 |doi=10.1073/pnas.95.7.3603 |display-authors=etal|bibcode=1998PNAS...95.3603Y}}
- {{cite journal | vauthors=Hateboer G, Wobst A, Petersen BO |title=Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6679–97 |year= 1998 |pmid= 9774682 | pmc=109252 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Ohtani K, Tsujimoto A, Ikeda M, Nakamura M |title=Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F |journal=Oncogene |volume=17 |issue= 14 |pages= 1777–85 |year= 1998 |pmid= 9778043 |doi= 10.1038/sj.onc.1202105 }}
- {{cite journal | vauthors=Stoeber K, Mills AD, Kubota Y |title=Cdc6 protein causes premature entry into S phase in a mammalian cell-free system |journal=EMBO J. |volume=17 |issue= 24 |pages= 7219–29 |year= 1999 |pmid= 9857179 | pmc=1171068 |doi= 10.1093/emboj/17.24.7219 |display-authors=etal}}
- {{cite journal | vauthors=Petersen BO, Lukas J, Sørensen CS |title=Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization |journal=EMBO J. |volume=18 |issue= 2 |pages= 396–410 |year= 1999 |pmid= 9889196 | pmc=1171134 |doi= 10.1093/emboj/18.2.396 |display-authors=etal}}
- {{cite journal | vauthors=van Hannen EJ, Zwart G, van Agterveld MP |title=Changes in Bacterial and Eukaryotic Community Structure after Mass Lysis of Filamentous Cyanobacteria Associated with Viruses |journal=Appl. Environ. Microbiol. |volume=65 |issue= 2 |pages= 795–801 |year= 1999 |pmid= 9925618 | pmc=91097 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Takei Y, Yamamoto K, Tsujimoto G |title=Identification of the sequence responsible for the nuclear localization of human Cdc6 |journal=FEBS Lett. |volume=447 |issue= 2–3 |pages= 292–6 |year= 1999 |pmid= 10214964 |doi=10.1016/S0014-5793(99)00306-3 }}
- {{cite journal | vauthors=Jiang W, Wells NJ, Hunter T |title=Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6193–8 |year= 1999 |pmid= 10339564 | pmc=26858 |doi=10.1073/pnas.96.11.6193 |bibcode=1999PNAS...96.6193J }}
- {{cite journal | vauthors=Fujita M, Yamada C, Goto H |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25927–32 |year= 1999 |pmid= 10464337 |doi=10.1074/jbc.274.36.25927 |display-authors=etal}}
- {{cite journal | vauthors=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1021–9 |year= 2000 |pmid= 10629059 | pmc=85219 |doi=10.1128/MCB.20.3.1021-1029.2000 }}
- {{cite journal | vauthors=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804–16 |year= 2000 |pmid= 10766737 | pmc=316494 |doi= 10.1101/gad.14.7.804 }}
- {{cite journal | vauthors=Takayama M, Taira T, Iguchi-Ariga SM, Ariga H |title=CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex |journal=FEBS Lett. |volume=477 |issue= 1–2 |pages= 43–8 |year= 2000 |pmid= 10899308 |doi=10.1016/S0014-5793(00)01756-7 }}
- {{cite journal | vauthors=Petersen BO, Wagener C, Marinoni F |title=Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1 |journal=Genes Dev. |volume=14 |issue= 18 |pages= 2330–43 |year= 2000 |pmid= 10995389 | pmc=316932 |doi=10.1101/gad.832500 |display-authors=etal}}
- {{cite journal | vauthors=Méndez J, Stillman B |title=Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis |journal=Mol. Cell. Biol. |volume=20 |issue= 22 |pages= 8602–12 |year= 2000 |pmid= 11046155 | pmc=102165 |doi=10.1128/MCB.20.22.8602-8612.2000 }}
- {{cite journal | vauthors=Delmolino LM, Saha P, Dutta A |title=Multiple mechanisms regulate subcellular localization of human CDC6 |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 26947–54 |year= 2001 |pmid= 11346650 |doi= 10.1074/jbc.M101870200 }}
- {{cite journal | vauthors=Fujita M, Ishimi Y, Nakamura H |title=Nuclear organization of DNA replication initiation proteins in mammalian cells |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10354–61 |year= 2002 |pmid= 11779870 |doi= 10.1074/jbc.M111398200 |display-authors=etal}}
- {{cite journal | vauthors=Biermann E, Baack M, Kreitz S, Knippers R |title=Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle |journal=Eur. J. Biochem. |volume=269 |issue= 3 |pages= 1040–6 |year= 2002 |pmid= 11846807 |doi=10.1046/j.0014-2956.2001.02746.x }}
- {{cite journal | vauthors=Robles LD, Frost AR, Davila M |title=Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25431–8 |year= 2002 |pmid= 12006585 |doi= 10.1074/jbc.M201199200 |display-authors=etal}}
{{refend}}External links{{DNA replication}} |