“Cefmetazole”的意思、由来-开放百科全书

词条

Cefmetazole

释义

Adverse effects
Spectrum of bacterial susceptibility
References

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| verifiedrevid = 460023468
| IUPAC_name = (6R,7S)-7-(2-(cyanomethylthio)acetamido)-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
| image = Cefmetazole.svg
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| MedlinePlus = a601206
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| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 56796-20-4
| ATC_prefix = J01
| ATC_suffix = DC09
| PubChem = 42008
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| DrugBank = DB00274
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| KEGG = D00910
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 3489
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201195
| C=15 | H=17 | N=7 | O=5 | S=3
| molecular_weight = 471.538 g/mol
| smiles = O=C2N1/C(=C(\\CS[C@@H]1[C@]2(OC)NC(=O)CSCC#N)CSc3nnnn3C)C(=O)O
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Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.

Adverse effects

The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.^[1]

Spectrum of bacterial susceptibility

Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. The following represents MIC susceptibility data for a few medically significant microorganisms.

Bacteroides fragilis: 0.06 - >256 µg/ml
Clostridium difficile: 8 - >128 µg/ml
Staphylococcus aureus: 0.5 - 256 µg/ml (includes MRSA)

^[2]

References

1. ^{{cite book |author=Stork CM |veditors=Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA |title=Goldfrank's toxicologic emergencies |chapter=Antibiotics, antifungals, and antivirals |chapterurl=https://books.google.com/books?id=cvJuLqBxGUcC&pg=PA847 |publisher=McGraw-Hill |location=New York |year=2006 |pages=847 |isbn=0-07-143763-0 |accessdate=2009-07-03}}
2. ^http://www.toku-e.com/Assets/MIC/Cefmetazole%20free%20acid.pdf

5 : Acetaldehyde dehydrogenase inhibitors|Cephalosporin antibiotics|Tetrazoles|Nitriles|Carboxamides

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