| 词条 | Cefonicid |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443509375 | IUPAC_name = (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetyl)amino]-8-oxo- 3[1-(sulfomethyl)tetrazol-5-yl]sulfanylmethyl 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | image = cefonicid.png | tradename = | Drugs.com = {{drugs.com|CONS|cefonicid}} | MedlinePlus = a601206 | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 61270-58-4 | ATC_prefix = J01 | ATC_suffix = DC06 | PubChem = 43594 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 39734 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 6532B86WFG | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07644 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 3491 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1601 | C=18 | H=18 | N=6 | O=8 | S=3 | molecular_weight = 542.569 g/mol | smiles = O=C2N1/C(=C(\\CS[C@@H]1[C@@H]2NC(=O)[C@H](O)c3ccccc3)CSc4nnnn4CS(=O)(=O)O)C(=O)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H18N6O8S3/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32)/t11-,13-,16-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = DYAIAHUQIPBDIP-AXAPSJFSSA-N }}Cefonicide (or cefonicid) is a cephalosporin antibiotic.[1] It has a density of 1.92g/cm3. SynthesisInjectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v. Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole. See also
References1. ^{{cite journal|pmid=3530703|year=1986|author1=Saltiel|first1=E|title=Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use|journal=Drugs|volume=32|issue=3|pages=222–59|last2=Brogden|first2=R. N.|doi=10.2165/00003495-198632030-00002}} {{CephalosporinAntiBiotics}}{{antibiotic-stub}}2. ^D. A. Berges, {{Cite patent|DE|2611270}}; idem, {{US patent|4048311}} (1976, 1977 both to Smith Kline). 3. ^{{US patent|4093723}}, {{US patent|4159373}} (1978, 1979 both to Smith Kline). 5 : Acetaldehyde dehydrogenase inhibitors|Cephalosporin antibiotics|Enantiopure drugs|Sulfonic acids|Tetrazoles |
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