| 词条 | Cefpodoxime |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 414053518 | IUPAC_name = (6R,7R)-7[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | image = Cefpodoxime.svg | width = 200 | synonyms = Cefprodoxime proxetil | tradename = Vantin, others | Drugs.com = {{drugs.com|monograph|vantin}} | MedlinePlus = a698024 | pregnancy_AU = B1 | pregnancy_US = B | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | routes_of_administration = Oral | bioavailability = 50% | protein_bound = 21% to 29% | metabolism = Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver | elimination_half-life = 2 hours | excretion = Renal, unchanged | CAS_number_Ref = {{cascite|changed|CAS}} | CAS_number = 80210-62-4 | ATC_prefix = J01 | ATC_suffix = DD13 | PubChem = 6335986 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB01416 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4891496 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 7R4F94TVGY | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07650 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 3504 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1672 | C=15 | H=17 | N=5 | O=6 | S=2 | molecular_weight = 427.458 g/mol | smiles = O=C2N1/C(=C(\\CS[C@@H]1[C@@H]2NC(=O)C(=N\\OC)/c3nc(sc3)N)COC)C(=O)O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WYUSVOMTXWRGEK-HBWVYFAYSA-N }} Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections. It was patented in 1980 and approved for medical use in 1989.[1] Spectrum of bacterial susceptibility and resistanceCefpodoxime has been used to fight pathogenic bacteria responsible for causing gonorrhoea, tonsillitis, pneumonia, and bronchitis. Representative pathogenic genera include Streptococcus, Haemophilus, and Neisseria. The following represents MIC susceptibility data for a few medically significant microorganisms.
Brand nameZoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day. Finecure, India markets the products under trade name Cefpo.[3]Toraxim (Delta Pharma Ltd. Bangladesh) Trucef (by Renata Limited, Bangladesh) Orelox (by Sanofi-Aventis)[4] MAPDOX-CV: Cefpodoxime and Clavulanic acid combination MONOTAX O (Cefpodoxime)/ MONOTAX CV (Cefpodoxime and Clavulanic acid combination) (by Zydus Healthcare Ltd.) References1. ^{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=495 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA495 |language=en}} 2. ^http://www.toku-e.com/Assets/MIC/Cefpodoxime%20Free%20acid.pdf 3. ^{{cite web |title= Anti Biotics and Anti Bacterial |url=http://www.finecurepharma.com/cephalosporins.htm#cefu5 |publisher=Finecurepharmaceuticalsltd | accessdate=2012-03-27}}{{dead link|date=February 2019}} 4. ^{{Cite web|title = Orelox - Drugs.com|url = https://www.drugs.com/international/orelox.html|website = www.drugs.com|accessdate = 2015-11-28}} External links
3 : Cephalosporin antibiotics|Thiazoles|Ketoximes |
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