| 词条 | CGK733 fraud |
| 释义 |
CGK733 was claimed to be an inhibitor of ATM/ATR kinases,[4][5] which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells. The original report garnered scientific attention,[6] but was retracted in 2008.[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.[7] The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science & Technology.[2] References1. ^{{cite journal |vauthors=Won J, Kim M, Kim N, Ahn JH, Lee WG, Kim SS, Chang KY, Yi YW, Kim TK |title=Small molecule-based reversible reprogramming of cellular lifespan |journal=Nat. Chem. Biol. |volume=2 |issue=7 |pages=369–74 |date=July 2006 |pmid=16767085 |doi=10.1038/nchembio800}}{{Retracted|pmid=18560433|intentional=yes}} {{DEFAULTSORT:Cgk733 Fraud}}2. ^1 {{cite journal |url=http://sciencenow.sciencemag.org/cgi/content/full/2008/305/1 |journal=Science Now |title=South Korean researcher suspended over charges of scientific misconduct|date=March 5, 2008|author=Dennis Normile|author2=Jennifer Couzin|accessdate=2008-03-17}} 3. ^{{cite web|url=http://pubs.acs.org/isubscribe/journals/cen/86/i12/html/8612notw3.html|work=Chemical & Engineering News|title=Data Duping|year=2008|author=Kenneth J. Moore|accessdate=2008-04-01}} 4. ^{{cite journal |vauthors=Bhattacharya S, Ray RM, Johnson LR |title=Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells |journal=Cell. Signal. |volume= 21|issue= 4|pages= 509–22|date=December 2008 |pmid=19136059 |doi=10.1016/j.cellsig.2008.12.003 |url=}} 5. ^{{cite journal |vauthors=Crescenzi E, Palumbo G, de Boer J, Brady HJ |title=Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy |journal=Clin. Cancer Res. |volume=14 |issue=6 |pages=1877–87 |date=March 2008 |pmid=18347191 |doi=10.1158/1078-0432.CCR-07-4298 |url=}} 6. ^{{cite web|url=http://pubs.acs.org/cen/news/84/i25/8425notw4.html|work=Chemical & Engineering News|title=Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells|year=2006|author=Sarah Everts|accessdate=2007-03-09}} 7. ^1 {{cite journal |vauthors=Won J, Kim M, Kim N |title=Retraction: small molecule-based reversible reprogramming of cellular lifespan |journal=Nat. Chem. Biol. |volume=4 |issue=7 |pages=431 |date=July 2008 |pmid=18560433 |doi=10.1038/nchembio0708-431|display-authors=etal}} 2 : Fraud|Scientific misconduct incidents |
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