“CGS-21680”的意思、由来-开放百科全书

词条

CGS-21680

释义

See also
References

{{Chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 403602802
| ImageFile = CGS21680.png
| IUPACName = 3-[4-[2-[ [6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
| OtherNames = CGS 21680
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 120225-54-9
| PubChem = 3086599
| IUPHAR_ligand2 = 424
| IUPHAR_ligand = 375
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 73283
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 331372
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 2343185
| SMILES = O=C(O)CCc1ccc(cc1)CCNc2nc(c3ncn(c3n2)[C@@H]4O[C@H](C(=O)NCC)[C@@H](O)[C@H]4O)N
| InChI = 1/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
| InChIKey = PAOANWZGLPPROA-RQXXJAGIBL
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = PAOANWZGLPPROA-RQXXJAGISA-N
|Section2={{Chembox Properties
| Formula = C₂₃H₂₉N₇O₆
| MolarMass = 499.52
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
}}

CGS-21680 is a specific adenosine A_2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A_2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

References

{{cite journal |vauthors=Mayer CA, Haxhiu MA, Martin RJ, Wilson CG |title=Adenosine A_2A receptors mediate GABAergic inhibition of respiration in immature rats |journal=J Appl Physiol |volume=100 |issue=1 |pages=91–97 |year=2006 |pmid=16141383 |doi=10.1152/japplphysiol.00459.2005}}
{{cite journal |vauthors=Xie S, Shafer G, Wilson CG, Martin HB |title=In vitro adenosine detection with a diamond-based sensor |journal=Dia Rel Mater |volume=15 |issue=2-3 |pages=225–228 |year=2006 |doi=10.1016/j.diamond.2005.08.018 |id=}}

4 : Nucleosides|Purines|Carboxamides|Adenosine receptor agonists

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References