Charles Erskine may refer to:

• Charles Erskine, Earl of Mar (1650–1689), Scottish nobleman
• Charles Erskine, Lord Tinwald (1680–1763), Scottish judge, Lord Advocate, MP for Dumfriesshire 1722–41 and for Tain Burghs 1734–42
• Charles Erskine (1716–1749), his son, Scottish lawyer, MP for Ayr Burghs
• Charles Erskine (cardinal) (1739–1811), Italian-Scottish papal diplomat and cardinal
• Sir Charles Erskine, 1st Baronet, of Alva (1643–1690), Scottish politician

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