| 词条 | Chiral shift reagent |
| 释义 |
A chiral shift reagent is a reagent used in analytical chemistry for determining the optical purity of a sample. Some analytical techniques such as HPLC and NMR, in their most commons forms, cannot distinguish enantiomers within a sample, but can distinguish diastereomers. Therefore, converting a mixture of enantiomers to a corresponding mixture of diastereomers can allow analysis. One method involves the reaction of a chiral derivatizing agent (CDA) with a mixture of enantiomers to produce diasteromers via covalent attachment. One of the most common CDA is Mosher's acid.[1] Another method involves non-covalent interactions. NMR shift reagents such as EuFOD and TRISPHAT take advantage of the formation of diastereomeric complexes between the shift reagent and the analytical sample.[2] References1. ^{{Cite journal | doi = 10.1021/jo01261a013| title = α-Methoxy-α-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines| journal = The Journal of Organic Chemistry| volume = 34| issue = 9| pages = 2543–2549| year = 1969| last1 = Dale| first1 = James A| last2 = Dull| first2 = David L| last3 = Mosher| first3 = Harry S}} {{chem-stub}}2. ^{{Cite book| doi = 10.1016/B978-044451010-5/50024-9| chapter = Lanthanide Nmr Shift Reagents| title = Modern Aspects of Rare Earths and Their Complexes| pages = 779–843| year = 2003| last1 = Sastri| first1 = V.S| last2 = Bünzli| first2 = Jean-Claude| last3 = Rao| first3 = V. Ramachandra| last4 = Rayudu| first4 = G.V.S| last5 = Perumareddi| first5 = J.R| isbn = 9780444510105}} 2 : Analytical reagents|Reagents for organic chemistry |
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