| 词条 | Chlorcyclizine |
| 释义 |
| Watchedfields = changed | verifiedrevid = 437187307 | IUPAC_name = 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine | image = Chlorcyclizine.png | tradename = | Drugs.com = {{drugs.com|international|chlorcyclizine}} | MedlinePlus = a682619 | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 82-93-9 | ATC_prefix = R06 | ATC_suffix = AE04 | PubChem = 2710 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2609 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = M26C4IP44P | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 22150 | C=18 | H=21 | Cl=1 | N=2 | molecular_weight = 300.826 g/mol | smiles = Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WFNAKBGANONZEQ-UHFFFAOYSA-N }}Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.[1][2][3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.[1][2][3] In addition to its antihistamine effects, chlorcyclizine also has some anticholinergic, antiserotonergic, and local anesthetic properties.[4][5] It also has been studied as a potential treatment for hepatitis C.[6][7] See also
References1. ^1 {{cite book | author = Swiss Pharmaceutical Society | title = Index Nominum 2000: International Drug Directory (Book with CD-ROM) | publisher = Medpharm Scientific Publishers | location = Boca Raton | year = 2000 | pages = | isbn = 3-88763-075-0 | oclc = | doi = | url = https://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA1228&dq=Chlorcyclizine&pg=PA212#v=onepage&q&f=false}} {{Antiemetics}}{{Analgesics}}{{Antihistamines}}{{Cholinergics}}{{Histaminergics}}{{Serotonergics}}{{Piperazines}}{{respiratory-system-drug-stub}}Klorsiklizin2. ^1 {{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | pages = | isbn = 0-412-46630-9 | oclc = | doi = | url = https://books.google.com/books?id=DeX7jgInYFMC&lpg=PA417&dq=Chlorcyclizine&pg=PA417#v=onepage&q&f=false}} 3. ^1 {{cite book |author1=Hall, Judith A. |author2=Morton, Ian | title = Concise dictionary of pharmacological agents: properties and synonyms | publisher = Kluwer Academic | location = | year = 1999 | pages = | isbn = 0-7514-0499-3 | oclc = | doi = | url = https://books.google.com/books?id=mqaOMOtk61IC&lpg=PA72&dq=Chlorcyclizine&pg=PA72#v=onepage&q&f=false}} 4. ^{{cite book | author = Dorland Staff | title = Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger (French Edition) | publisher = Elsevier (Educa Books) | location = | year = 2008 | pages = | isbn = 2-84299-899-5 | oclc = | doi = | url = https://books.google.com/books?id=tQNqwsnkK-QC&lpg=PA1152&dq=chlorcyclizine%20anticholinergic&pg=PA1152#v=onepage&q&f=false}} 5. ^{{cite journal | vauthors = Rogóz Z, Skuza G, Sowińska H | title = The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice | journal = Polish Journal of Pharmacology and Pharmacy | volume = 33 | issue = 4 | pages = 459–65 |date=November 1981 | pmid = 6120505 }} 6. ^{{Cite journal | doi = 10.1126/scitranslmed.3010286 | title = Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection | journal = Science Translational Medicine | volume = 7 | issue = 282 | pages = 282ra49 | year = 2015 | last1 = He | first1 = S. | last2 = Lin | first2 = B. | last3 = Chu | first3 = V. | last4 = Hu | first4 = Z. | last5 = Hu | first5 = X. | last6 = Xiao | first6 = J. | last7 = Wang | first7 = A. Q. | last8 = Schweitzer | first8 = C. J. | last9 = Li | first9 = Q. | last10 = Imamura | first10 = M. | last11 = Hiraga | first11 = N. | last12 = Southall | first12 = N. | last13 = Ferrer | first13 = M. | last14 = Zheng | first14 = W. | last15 = Chayama | first15 = K. | last16 = Marugan | first16 = J. J. | last17 = Liang | first17 = T. J. | pmid=25855495}} 7. ^{{cite journal|last1=Chamoun-Emanuelli|first1=Ana Maria|last2=Pecheur|first2=Eve-Isabelle|last3=Chen|first3=Zhilei|title=Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virus|journal=Antiviral Research|date=July 2014|volume=109|pages=141–148|doi=10.1016/j.antiviral.2014.06.014}} 3 : H1 receptor antagonists|Chloroarenes|Piperazines |
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