“Cholestenone 5alpha-reductase”的意思、由来-开放百科全书

词条

Cholestenone 5alpha-reductase

释义

References

{{enzyme
| Name = cholestenone 5-alpha-reductase
| EC_number = 1.3.1.22
| CAS_number = 37255-34-8
| IUBMB_EC_number = 1/3/1/22
| GO_code = 0047751
| image =
| width =
| caption =
}}

In enzymology, a cholestenone 5alpha-reductase ({{EC number|1.3.1.22}}) is an enzyme that catalyzes the chemical reaction

5alpha-cholestan-3-one + NADP⁺ cholest-4-en-3-one + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-cholestan-3-one and NADP⁺, whereas its 3 products are cholest-4-en-3-one, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase. Other names in common use include testosterone Delta4-5alpha-reductase, steroid 5alpha-reductase, 3-oxosteroid Delta4-dehydrogenase, 5alpha-reductase, steroid 5alpha-hydrogenase, 3-oxosteroid 5alpha-reductase, testosterone Delta4-hydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, reduced nicotinamide adenine dinucleotide, phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase, 4-ene-5alpha-reductase, Delta4-3-ketosteroid 5alpha-oxidoreductase, cholest-4-en-3-one 5alpha-reductase, and testosterone 5alpha-reductase.

References

{{cite journal | vauthors = Shefer S, Hauser S, Mosbach EH | date = 1966 | title = Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. I Cholestenone 5-alpha-reductase of rat liver | journal = J. Biol. Chem. | volume = 241 | pages = 946–52 | pmid = 5907469 | issue = 4 }}

3 : EC 1.3.1|NADPH-dependent enzymes|Enzymes of unknown structure

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