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词条 Chromosome 21
释义

  1. Genes

      Number of genes    Gene list  

  2. Diseases and disorders

  3. Chromosomal conditions

  4. Cytogenetic band

  5. References

  6. External links

{{more footnotes|date=February 2013}}{{Infobox chromosome
| image = Human male karyotpe high resolution - Chromosome 21 cropped.png
| caption = Human chromosome 21 pair after G-banding.
One is from mother, one is from father.
| image2 = Human male karyotpe high resolution - Chromosome 21.png
| caption2 = Chromosome 21 pair
in human male karyogram.
| length_bp = 46,709,983 bp
(GRCh38)[1]
| genes = 215 (CCDS)[2]
| type = Autosome
| centromere_position = Acrocentric[2]
(12.0 Mbp[3])
| chr = 21
| ensembl_id = 21
| entrez_id = 21
| ncbi_id = 21
| ucsc_id = 21
| refseq_id = NC_000021
| genbank_id = CM000683
}}

Chromosome 21 is one of the 23 pairs of chromosomes in humans. Chromosome 21 is both the smallest human autosome and chromosome,[4] with 48 million nucleotides (the building material of DNA) representing about 1.5 percent of the total DNA in cells. Most people have two copies of chromosome 21, while those with three copies of chromosome 21 have Down syndrome, also called "trisomy 21".

Researchers working on the Human Genome Project announced in May 2000 that they had determined the sequence of base pairs that make up this chromosome.[5] Chromosome 21 was the second human chromosome to be fully sequenced, after chromosome 22.

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 21. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[6]

Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date
CCDS 215 — —[7] 2016-09-08
HGNC 217 165 180[8] 2017-05-12
Ensembl 234 404 183[9] 2017-03-29
UniProt 252 — —[10] 2018-02-28
NCBI 256 356 207[11][12][13] 2017-05-19

Gene list

{{Category see also|Genes on human chromosome 21}}

The following is a partial list of genes on human chromosome 21. For complete list, see the link in the infobox on the right.

{{columns-list|
  • ADAMTS1
  • APP: amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)[14]
  • C21orf45: encoding protein Protein Mis18-alpha
  • C21orf55/DNAJC28: encoding protein DnaJ homolog subfamily C member 28
  • C21orf56: encoding protein Uncharacterized protein C21orf56
  • C21orf59: Chromosome 21 open reading frame 59
  • C21orf62: expressed in tissues of the brain and reproductive organs
  • C21orf66: encoding protein GC-rich sequence DNA-binding factor homolog
  • CBS: cystathionine-beta-synthase
  • CLDN14: claudin 14
  • CRYZL1: Crystallin zeta-like 1
  • CTSB
  • CYYR1: Cysteine and tyrosine rich 1
  • DIP2A: Disco-interacting protein 2 homolog A
  • DOPEY2: Dopey family member 2
  • DSCR1: Down Syndrome critical region 1[15]
  • DYRK1A: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • ERG
  • ETS2
  • FAM3B: Family with sequence similarity 3 member B
  • FRGCA: encoding protein FOXM1-regulated, gastric cancer associated
  • HLCS: holocarboxylase synthetase (biotin-(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
  • KCNE1: potassium voltage-gated channel, Isk-related family, member 1
  • KCNE2: potassium voltage-gated channel, Isk-related family, member 2
  • LAD: leukocyte adhesion deficiency (symbols are ITGB2, CD18, LCAMB)
  • NRIP1
  • OLIG2
  • PCNT: centrosomal pericentrin
  • PDXK: encoding enzyme Pyridoxal kinase
  • PSMG1: Proteasome assembly chaperone 1
  • RNR4: RNA, ribosomal 45S cluster 4
  • RRP1: encoding protein Ribosomal RNA processing protein 1 homolog A
  • RRP1B: ribosomal RNA processing 1 homolog B
  • RWDD2B: encoding protein RWD domain-containing protein 2B
  • RUNX1
  • S100B: calcium binding protein
  • SOD1: superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))
  • TFF1, TFF2, TFF3
  • TIAM1
  • TMEM1: encoding protein Trafficking protein particle complex subunit 10
  • TMPRSS2
  • TMPRSS3: transmembrane protease, serine 3
  • TTC3: Tetratricopeptide Repeat Domain 3

}}

Diseases and disorders

The following diseases are some of those related to genes on chromosome 21:

  • Alzheimer's disease[14]
  • Amyotrophic lateral sclerosis
  • Autoimmune polyendocrine syndrome
  • Down syndrome
  • Erondu–Cymet syndrome
  • Holocarboxylase synthetase deficiency
  • Homocystinuria
  • Jervell and Lange-Nielsen syndrome
  • Leukocyte adhesion deficiency
  • Majewski osteodysplastic primordial dwarfism type II (MOPD II, or MOPD2)
  • Nonsyndromic deafness
  • Romano–Ward syndrome

Chromosomal conditions

The following conditions are caused by changes in the structure or number of copies of chromosome 21:

  • Cancers: Rearrangements (translocations) of genetic material between chromosome 21 and other chromosomes have been associated with several types of cancer. For example, acute lymphoblastic leukemia (a type of blood cancer most often diagnosed in childhood) has been associated with a translocation between chromosomes 12 and 21. Another form of leukemia, acute myeloid leukemia, has been associated with a translocation between chromosomes 8 and 21.
  • In a small percentage of cases, Down syndrome is caused by a rearrangement of chromosomal material between chromosome 21 and another chromosome. As a result, a person has the usual two copies of chromosome 21, plus extra material from chromosome 21 attached to another chromosome. These cases are called translocation Down syndrome. Researchers believe that extra copies of genes on chromosome 21 disrupt the course of normal development, causing the characteristic features of Down syndrome and the increased risk of medical problems associated with this disorder.
  • Other changes in the number or structure of chromosome 21 can have a variety of effects, including intellectual disability, delayed development, and characteristic facial features. In some cases, the signs and symptoms are similar to those of Down syndrome. Changes to chromosome 21 include a missing segment of the chromosome in each cell (partial monosomy 21) and a circular structure called ring chromosome 21. A ring chromosome occurs when both ends of a broken chromosome are reunited.
  • Duplication in Amyloid precursor protein (APP) locus (duplicated segment varies in length but includes APP) on Chromosome 21 was found to cause early onset familial Alzheimer's disease in a French family set (Rovelet-Lecrux et al.) and a Dutch family set.[14] Compared to Alzheimer's caused by missense mutations in APP, the frequency of the Alzheimer's caused by APP duplications is significant. All patients that have an extra copy of APP gene due to the locus duplication show Alzheimer's with severe cerebral amyloid angiopathy.

Cytogenetic band

{{multiple image
| header = G-banding ideograms of human chromosome 21
| total_width = 400
| image1 = Human chromosome 21 ideogram vertical.svg
| width1 = 216
| height1= 1125
| caption1 = G-banding ideogram of human chromosome 21 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser).
| image2 = Human chromosome 21 - 400 550 850 bphs.png
| width2 = 1003
| height2= 2801
| caption2 = G-banding patterns of human chromosome 21 in three different resolutions (400,[16] 550[17] and 850[18]). Band length in this diagram is based on the ideograms from ISCN (2013).[19] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process.[20]
}}
G-bands of human chromosome 21 in resolution 850 bphs[21]
Chr. Arm[22] Band[23] ISCN
start[24]		 ISCN
stop[24]		 Basepair
start		 Basepair
stop		 Stain[25] Density
21 p13 0 311 1|fmt=commas}}3100000|fmt=commas}}gvar
21 p12 311 683 3100001|fmt=commas}}7000000|fmt=commas}}stalk
21 p11.2 683 1056 7000001|fmt=commas}}10900000|fmt=commas}}gvar
21 p11.1 1056 1274 10900001|fmt=commas}}12000000|fmt=commas}}acen
21 q11.1 1274 1367 12000001|fmt=commas}}13000000|fmt=commas}}acen
21 q11.2 1367 1584 13000001|fmt=commas}}15000000|fmt=commas}}gneg
21 q21.1 1584 2019 15000001|fmt=commas}}22600000|fmt=commas}}gpos 100
21 q21.2 2019 2144 22600001|fmt=commas}}25500000|fmt=commas}}gneg
21 q21.3 2144 2330 25500001|fmt=commas}}30200000|fmt=commas}}gpos 75
21 q22.11 2330 2485 30200001|fmt=commas}}34400000|fmt=commas}}gneg
21 q22.12 2485 2610 34400001|fmt=commas}}36400000|fmt=commas}}gpos 50
21 q22.13 2610 2703 36400001|fmt=commas}}38300000|fmt=commas}}gneg
21 q22.2 2703 2858 38300001|fmt=commas}}41200000|fmt=commas}}gpos 50
21 q22.3 2858 3200 41200001|fmt=commas}}46709983|fmt=commas}}gneg
{{clear}}

References

1. ^{{cite web | title=Human Genome Assembly GRCh38 - Genome Reference Consortium | website=National Center for Biotechnology Information | date=2013-12-24 | url=https://www.ncbi.nlm.nih.gov/grc/human/data?asm=GRCh38 | language=en | accessdate=2017-03-04}}
2. ^{{cite book|author1=Tom Strachan|author2=Andrew Read|title=Human Molecular Genetics|url=https://books.google.com/books?id=dSwWBAAAQBAJ&pg=PA45|date=2 April 2010|publisher=Garland Science|isbn=978-1-136-84407-2|page=45}}
3. ^Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
4. ^{{cite web | url=https://ghr.nlm.nih.gov/chromosome/21 | title=Chromosome 21}}
5. ^{{Cite journal | doi=10.1038/35012518|pmid = 10830953| title=The DNA sequence of human chromosome 21| journal=Nature| volume=405| issue=6784| pages=311–319| year=2000| last1=Hattori| first1=M.| last2=Fujiyama| first2=A.| last3=Taylor| first3=T. D.| last4=Watanabe| first4=H.| last5=Yada| first5=T.| last6=Park| first6=H.-S.| last7=Toyoda| first7=A.| last8=Ishii| first8=K.| last9=Totoki| first9=Y.| last10=Choi| first10=D.-K.| last11=Soeda| first11=E.| last12=Ohki| first12=M.| last13=Takagi| first13=T.| last14=Sakaki| first14=Y.| last15=Taudien| first15=S.| last16=Blechschmidt| first16=K.| last17=Polley| first17=A.| last18=Menzel| first18=U.| last19=Delabar| first19=J.| last20=Kumpf| first20=K.| last21=Lehmann| first21=R.| last22=Patterson| first22=D.| last23=Reichwald| first23=K.| last24=Rump| first24=A.| last25=Schillhabel| first25=M.| last26=Schudy| first26=A.| last27=Zimmermann| first27=W.| last28=Rosenthal| first28=A.| last29=Kudoh| first29=J.| last30=Shibuya| first30=K.| displayauthors=29}}
6. ^{{cite journal| author=Pertea M, Salzberg SL| title=Between a chicken and a grape: estimating the number of human genes. | journal=Genome Biol | year= 2010 | volume= 11 | issue= 5 | pages= 206 | pmid=20441615 | doi=10.1186/gb-2010-11-5-206 | pmc=2898077 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20441615 }}
7. ^1 {{cite web | title=Search results - 21[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene | website= NCBI |version = CCDS Release 20 for Homo sapiens | url=https://www.ncbi.nlm.nih.gov/gene?term=21%5BChr%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22has%20ccds%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch |date=2016-09-08 | accessdate=2017-05-28}}
8. ^{{cite web | title=Statistics & Downloads for chromosome 21 | website=HUGO Gene Nomenclature Committee | url=https://www.genenames.org/cgi-bin/statistics?c=21 |date=2017-05-12 | accessdate=2017-05-19}}
9. ^{{cite web | title=Chromosome 21: Chromosome summary - Homo sapiens | website= Ensembl Release 88 | url=http://mar2017.archive.ensembl.org/Homo_sapiens/Location/Chromosome?r=21 |date=2017-03-29 | accessdate=2017-05-19}}
10. ^{{cite web | title=Human chromosome 21: entries, gene names and cross-references to MIM | website= UniProt | url=https://www.uniprot.org/docs/humchr21.txt |date=2018-02-28 | accessdate=2018-03-16}}
11. ^{{cite web | title=Search results - 21[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene | website=NCBI | date=2017-05-19 | url=https://www.ncbi.nlm.nih.gov/gene?term=21%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22genetype%20protein%20coding%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch | accessdate=2017-05-20}}
12. ^{{cite web | title=Search results - 21[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene | website=NCBI | date=2017-05-19 | url=https://www.ncbi.nlm.nih.gov/gene?term=21%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%28%22genetype%20miscrna%22%5BProperties%5D%20OR%20%22genetype%20ncrna%22%5BProperties%5D%20OR%20%22genetype%20rrna%22%5BProperties%5D%20OR%20%22genetype%20trna%22%5BProperties%5D%20OR%20%22genetype%20scrna%22%5BProperties%5D%20OR%20%22genetype%20snrna%22%5BProperties%5D%20OR%20%22genetype%20snorna%22%5BProperties%5D%29%20NOT%20%22genetype%20protein%20coding%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch | accessdate=2017-05-20}}
13. ^{{cite web | title=Search results - 21[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene | website=NCBI | date=2017-05-19 | url=https://www.ncbi.nlm.nih.gov/gene?term=21%5BCHR%5D%20AND%20%22Homo%20sapiens%22%5BOrganism%5D%20AND%20%28%22genetype%20pseudo%22%5BProperties%5D%20AND%20alive%5Bprop%5D%29&cmd=DetailsSearch | accessdate=2017-05-20}}
14. ^1 2 {{cite journal | vauthors= Sleegers K, Brouwers N, Gijselinck I, Theuns J, Goossens D, Wauters J, Del-Favero J, Cruts M, van Duijn CM, Van Broeckhoven C | title=APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy | journal= Brain | year=2006 | pages= 2977–83| volume= 129| issue= Pt 11| pmid=16921174 | doi=10.1093/brain/awl203}}
15. ^{{cite journal | vauthors=Gardiner K, Davisson M | title=The sequence of human chromosome 21 and implications for research into Down syndrome | journal=Genome Biol | year=2000 | pages=REVIEWS0002 | volume=1 | issue=2 | pmid=11178230 | doi=10.1186/gb-2000-1-2-reviews0002 | pmc=138845}}
16. ^Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
17. ^Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
18. ^Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
19. ^{{cite book|author=International Standing Committee on Human Cytogenetic Nomenclature|title=ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013)|url=https://books.google.com/books?id=lGCLrh0DIwEC|year=2013|publisher=Karger Medical and Scientific Publishers|isbn=978-3-318-02253-7}}
20. ^{{cite journal|last1=Sethakulvichai|first1=W.|last2=Manitpornsut|first2=S.|last3=Wiboonrat|first3=M.|last4=Lilakiatsakun|first4=W.|last5=Assawamakin|first5=A.|last6=Tongsima|first6=S.|title=Estimation of band level resolutions of human chromosome images|year=2012|pages=276–282|journal=In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on|doi=10.1109/JCSSE.2012.6261965|url=https://www.researchgate.net/profile/Anunchai_Assawamakin/publication/261304470_Estimation_of_band_level_resolutions_of_human_chromosome_images/links/5459f7ff0cf2cf516483fffd/Estimation-of-band-level-resolutions-of-human-chromosome-images.pdf|isbn=978-1-4673-1921-8}}
21. ^Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
22. ^"p": Short arm; "q": Long arm.
23. ^For cytogenetic banding nomenclature, see article locus.
24. ^1 These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
25. ^gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
  • {{cite journal | vauthors=Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S | title=Chromosome 21 and down syndrome: from genomics to pathophysiology | journal=Nat Rev Genet | year=2004 | pages=725–38 | volume=5 | issue=10 | pmid=15510164 | doi=10.1038/nrg1448}}
  • {{cite journal | vauthors=Antonarakis SE, Lyle R, Deutsch S, Reymond A | title=Chromosome 21: a small land of fascinating disorders with unknown pathophysiology | journal=Int J Dev Biol | year=2002 | pages=89–96 | volume=46 | issue=1 | pmid=11902692}}
  • {{cite journal | author=Antonarakis SE | title=Chromosome 21: from sequence to applications | journal=Curr Opin Genet Dev | year=2001 | pages=241–6 | volume=11 | issue=3 | pmid=11377958 | doi=10.1016/S0959-437X(00)00185-4}}
  • {{cite journal | author=Gilbert F | title=Disease genes and chromosomes: disease maps of the human genome. Chromosome 21 | journal=Genet Test | year=1997 | pages=301–6 | volume=1 | issue=4 | pmid=10464663 | doi=10.1089/gte.1997.1.301}}
  • {{cite journal | vauthors=Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title=The DNA sequence of human chromosome 21 | journal=Nature | year=2000 | pages=311–9 | volume=405 | issue=6784 | pmid=10830953 | doi=10.1038/35012518}}
  • {{cite journal | vauthors=Sawinska M, Ladon D | title=Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia | journal=Leuk Res | year=2004 | pages=35–42 | volume=28 | issue=1 | pmid=14630078 | doi=10.1016/S0145-2126(03)00160-7}}
  • {{cite journal | vauthors= Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D

| title=APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy | journal=Nature Genetics | year=2005 | pages= 24–6| volume= 38| issue= 1| pmid=16369530
| doi=10.1038/ng1718}}
  • {{cite journal | author= Anita Rauch | author2= Christian T. Thiel | author3= Detlev Schindler | author4= Ursula Wick | author5= Yanick J. Crow | author6= Arif B. Ekici | author7= Anthonie J. van Essen| author8= Timm O. Goecke | author9= Lihadh Al-Gazali | author9-link= Lihadh Al-Gazali| author10= Krystyna H. Chrzanowska | author11= Christiane Zweier| author12= Han G. Brunner | author13= Kristin Becker| author14= Cynthia J. Curry | author15= Bruno Dallapiccola | author16= Koenraad Devriendt | author17= Arnd Dörfler | author18= Esther Kinning | author19= André Megarbane | author20= Peter Meinecke | author21= Robert K. Semple | author22= Stephanie Spranger | author23= Annick Toutain | author24= Richard C. Trembath | author25= Egbert Voss | author26= Louise Wilson | author27= Raoul Hennekam | author28= Francis de Zegher | author29= Helmut-Günther Dörr| author30= André Reis

| title=Mutations in the Pericentrin (PCNT) Gene Cause Primordial Dwarfism| journal=Science Online| year=2008 | pages= 7| volume= | issue= | id=}}

External links

{{Commons category|Human chromosome 21}}
  • {{cite web | author= National Institutes of Health | title= Chromosome 21 | work= Genetics Home Reference | url= http://ghr.nlm.nih.gov/chromosome=21| accessdate=2017-05-06}}
  • {{Cite web|url=http://web.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/chromo21.shtml|title=Chromosome 21|website=Human Genome Project Information Archive 1990–2003|access-date=2017-05-06}}
{{Chromosomes}}{{Chromosome genetics}}{{DEFAULTSORT:Chromosome 21 (Human)}}

2 : Chromosomes (human)|Genes on human chromosome 21
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