“Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase”的意思、由来-开放百科全书

词条

Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

释义

References

{{enzyme
| Name = cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
| EC_number = 1.3.1.19
| CAS_number = 51923-03-6
| IUBMB_EC_number = 1/3/1/19
| GO_code = 0018504
| image =
| width =
| caption =
}}

In enzymology, a cis-1,2-dihydrobenzene-1,2-diol dehydrogenase ({{EC number|1.3.1.19}}) is an enzyme that catalyzes the chemical reaction

cis-1,2-dihydrobenzene-1,2-diol + NAD⁺ catechol + NADH + H⁺

Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD⁺, whereas its 3 products are catechol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase. Other names in common use include cis-benzene glycol dehydrogenase, cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine, and dinucleotide) oxidoreductase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, toluene and xylene degradation, naphthalene and anthracene degradation, and styrene degradation.

References

{{cite journal | vauthors = Axcell BC, Geary PJ | date = 1973 | title = The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase) | journal = Biochem. J. | volume = 136 | pages = 927–34 | pmid = 4362337 | issue = 4 | pmc = 1166042 }}
{{cite journal | vauthors = Gibson DT, Koch JR, Kallio RE | date = 1968 | title = Oxidative degradation of aromatic hydrocarbons by microorganisms. I Enzymatic formation of catechol from benzene | journal = Biochemistry | volume = 7 | pages = 2653–62 | pmid = 4298226 | doi = 10.1021/bi00847a031 | issue = 7 }}

3 : EC 1.3.1|NADH-dependent enzymes|Enzymes of unknown structure

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