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词条 Butyramide
释义

  1. Synthesis

  2. Derivatives

  3. See also

  4. References

  5. External links

{{chembox
| Watchedfields = changed
| verifiedrevid = 443493356
| Reference=[1]
| Name = Butyramide
| ImageFile = Butyramide.png
| ImageSize = 160px
| ImageName = Skeletal formula
| ImageFile1 = Butyramide-3D-balls.png
| ImageSize1 = 180px
| ImageName1 = Ball-and-stick model
| IUPACName = Butanamide
| OtherNames = Butyramide
n-Butylamide
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10464
| PubChem = 10927
| InChI = 1/C4H9NO/c1-2-3-4(5)6/h2-3H2,1H3,(H2,5,6)
| InChIKey = DNSISZSEWVHGLH-UHFFFAOYAW
| SMILES1 = O=C(N)CCC
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C4H9NO/c1-2-3-4(5)6/h2-3H2,1H3,(H2,5,6)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = DNSISZSEWVHGLH-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 541-35-5
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB02121
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 9J6OR937VR
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 50724
| SMILES = CCCC(N)=O
|Section2={{Chembox Properties
| C = 4
| H = 9
| N = 1
| O = 1
| Density = 1.03 g/cm3
| MeltingPtC = 115 to 116
| BoilingPtC = 216
}}

Butyramide is the amide of butyric acid. It has the molecular formula C3H7CONH2. It is a white solid that freely soluble in water and ethanol, but slightly soluble in diethyl ether. At room temperature, butyramide is a crystalline solid and in contrast to butyric acid, it is devoid of unpleasant, rancid smell.

Synthesis

Butyramide can be synthesized by:

  • catalytic hydration of butyronitrile;
  • reaction of butyryl chloride with ammonium salts;
  • reduction of butyraldoxime.

Derivatives

Some of its derivatives have shown preliminary strong anticonvulsive activity and inhibitory action on histone deacetylases, crucial enzymes controlling the proliferative or differentiation status of most cells.

See also

  • Isobutyramide

References

1. ^Merck Index, 11th Edition, 1592
{{morefootnotes|date=November 2015}}
  • Jiang J et al. PLos One 2012; 7(3): e34283
  • Liu WH et al. Yao Xue Xue Bao 2012 Feb; 47(2): 194-99.
  • Vitorivic-Todorovic MD et al. Bioorg Med Chem 2010 Feb; 18(3): 1181-93.

External links

  • {{Commonscatinline|Butyramides}}

1 : Butyramides

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