| 词条 | Cleavage stimulation factor |
| 释义 |
Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein, made up of the proteins CSTF1 (55kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule. CstF is recruited by cleavage and polyadenylation specificity factor (CPSF) and assembles into a protein complex on the 3' end to promote the synthesis of a functional polyadenine tail, which results in a mature mRNA molecule ready to be exported from the cell nucleus to the cytosol for translation. The amount of CstF in a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0 phase to S phase in mouse fibroblast and human splenic B cells.[1] Genes
References1. ^{{Cite journal | last1 = Martincic | first1 = K. | last2 = Campbell | first2 = R. | last3 = Edwalds-Gilbert | first3 = G. | last4 = Souan | first4 = L. | last5 = Lotze | first5 = M. T. | last6 = Milcarek | first6 = C. | title = Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11095–11100 | year = 1998 | pmid = 9736695 | pmc = 21601 | doi=10.1073/pnas.95.19.11095}} Further reading
External links
3 : Protein complexes|Gene expression|RNA-binding proteins |
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