| 词条 | Clofoctol |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443553734 | IUPAC_name = 2-[(2,4-dichlorophenyl)methyl]- 4-(2,4,4-trimethylpentan-2-yl)phenol | image = Clofoctol.svg | alt = Structural formula of clofoctol | width = 250 | image2 = Clofoctol 3D ball.png | alt2 = Ball-and-stick model of the clofoctol molecule | width2 = 220 | tradename = | Drugs.com = {{drugs.com|international|clofoctol}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Rectal (suppository)[1] | bioavailability = 98%[1] | protein_bound = | metabolism = Hepatic glucuronidation[1] | elimination_half-life = | excretion = Biliary[1] | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 37693-01-9 | ATC_prefix = J01 | ATC_suffix = XX03 | PubChem = 2799 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL = 1476605 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2697 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 704083NI0R | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07244 | C=21 | H=26 | Cl=2 | O=1 | molecular_weight = 365.336 g/mol | smiles = Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HQVZOORKDNCGCK-UHFFFAOYSA-N }}Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus. It is only functional against Gram-positive bacteria.[2] It penetrates into human lung tissue.[3] References1. ^1 2 3 4 {{cite web | url = http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm | title = Gramplus | date = July 25, 2007 | accessdate = 2007-08-10 | publisher = Studio Medico Torrino | language = Italian}} {{Other antibacterials}}{{Antibiotic-stub}}2. ^{{cite journal |vauthors=Combe J, Simonnet F, Yablonsky F, Simonnet G |title=[Clofoctol binding by the bacteria (author's transl)] |language=French |journal=J Pharmacol |volume=11 |issue=4 |pages=411–25 |year=1980 |pmid=6782374 |doi=}} 3. ^{{cite journal |vauthors=Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M |title=A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay |journal=Drugs Exp Clin Res |volume=14 |issue=1 |pages=39–43 |year=1988 |pmid=3391105 |doi= |url=}} 3 : Antibiotics|Phenols|Chloroarenes |
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