| 词条 | Co-dydramol |
| 释义 |
| verifiedrevid = 447540223 | image = Dihydrocodeine and paracetamol.svg | width = 165 | type = combo | component1 = Dihydrocodeine | class1 = Opioid analgesic | component2 = Paracetamol | class2 = Non-opioid analgesic | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = POM | legal_US = | legal_status = | routes_of_administration = Oral | bioavailability = ~20% (Oral) | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = }} Co-dydramol (BAN) is a non-proprietary name used to denote a particular compound analgesic, a combination of dihydrocodeine tartrate and paracetamol. Co-dydramol tablets are used for the relief of moderate pain. Co-dydramol is part of a series of combination drugs available in the UK and other countries including co-codaprin (aspirin and codeine). FormulationsAll formulations of co-dydramol contain 500 mg of paracetamol per tablet and may only be sold at a pharmacy as an over-the-counter item without prescription (a P medicine) if containing less than 7.5 mg of dihydrocodeine per tablet. Higher strengths are prescription only medicines. There are no GSL formulations of co-dydramol, as it is a Schedule 5 controlled drug. Four strengths of dihydrocodeine tartrate in each tablet are available:
MetabolismDihydrocodeine is metabolised by the CYP450 system isoenzyme 2D6 to dihydromorphine, which mediates the majority of its analgesic effects. Owing to the low oral bioavailibility of dihydrocodeine (20%), and its subsequent metabolism to active compounds, it is likely that doses below 30mg are sub therapeutic for analgesia. References
See also
3 : Combination analgesics|Hepatotoxins|Semisynthetic_opioids |
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