| 词条 | Complement receptor | ||||||||||||||||||||||||||||
| 释义 |
}}{{Pfam_box | Symbol = Complement receptor | Name = Complement receptor | image = | width = | caption = | InterPro= | SMART= | PROSITE = | SCOP = | TCDB = | OPM family= | OPM protein= | Pfam= | PDB= | Membranome family= 116 }} A complement receptor is a receptor of the complement system, part of the innate immune system. Complement receptors bind proteins of the complement system, and can thus detect pathogens without mediation by antibodies.[1] Complement activity can be triggered by specific antigen-antibody complexes, sugars or pathogens directly. Complement receptorsMany white blood cells express complement receptors on their surface, particularly monocytes and macrophages. All four complement receptors bind to fragments of complement component 3 or complement component 4 coated on pathogen surface, but the receptors have different functions. Complement receptor (CR) 1, 3, and 4 work as opsonins (stimulate phagocytosis), whereas CR2 is expressed only on B cells as a co-receptor. Red blood cells (RBCs) also express CR1. With these receptors, RBCs bring antigen-antibody complexes bound to complement fragments in the blood to the liver and spleen for degradation.[2]
Clinical significanceDefects in these receptors can be associated with disease.[3] See also
References1. ^1 {{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK27100|title=The complement system and innate immunity|last=Janeway|first=CA Jr|author2=Travers P|author3=Walport M|year=2001|work=Immunobiology: The Immune System in Health and Disease|publisher=Garland Science|accessdate=29 December 2017|location=New York|display-authors=etal}} 2. ^{{cite|author= Peter Parham|title=The Immune System|edition=2nd|publisher=Taylor&Francis}} 3. ^{{cite web |url=http://emedicine.medscape.com/article/1051238-overview |title=Complement Receptor Deficiency: eMedicine Dermatology |format= |work= |accessdate=2010-12-07}} External links
2 : Complement system|Single-pass transmembrane proteins |
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