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词条 COUP-TFI
释义

  1. Function

  2. Interactions

  3. References

  4. External links

  5. Further reading

{{Infobox_gene}}

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]

Interactions

COUP-TFI has been shown to interact with:

  • BCL11A,[6]
  • BCL11B,[6]
  • COPS2,[7] and
  • ESR1.[8]

References

1. ^{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}
2. ^{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = Sep 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 }}
3. ^{{cite journal | vauthors = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 12 | pages = 4259–67 | date = Dec 1986 | pmid = 3796602 | pmc = 367207 | doi = 10.1128/MCB.6.12.4259 }}
4. ^{{cite journal | vauthors = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | date = Aug 1987 | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X }}
5. ^{{cite journal | vauthors = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocrine Reviews | volume = 18 | issue = 2 | pages = 229–40 | date = Apr 1997 | pmid = 9101138 | doi = 10.1210/er.18.2.229 }}
6. ^1 {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}
7. ^{{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi=10.1128/mcb.19.5.3383}}
8. ^{{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}
{{clear}}

External links

  • {{UCSC gene info|NR2F1}}
  • {{UCSC gene info|NR2F2}}

Further reading

{{Refbegin|33em}}
  • {{cite journal | vauthors = Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM | title = Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1448–52 | date = Feb 1992 | pmid = 1311101 | pmc = 48468 | doi = 10.1073/pnas.89.4.1448 }}
  • {{cite journal | vauthors = Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA | title = Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein | journal = Molecular Endocrinology | volume = 6 | issue = 9 | pages = 1468–78 | date = Sep 1992 | pmid = 1331778 | doi = 10.1210/me.6.9.1468 }}
  • {{cite journal | vauthors = Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW | title = Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) | journal = The Journal of Biological Chemistry | volume = 267 | issue = 25 | pages = 17617–23 | date = Sep 1992 | pmid = 1517211 | doi = }}
  • {{cite journal | vauthors = Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW | title = COUP transcription factor is a member of the steroid receptor superfamily | journal = Nature | volume = 340 | issue = 6229 | pages = 163–6 | date = Jul 1989 | pmid = 2739739 | doi = 10.1038/340163a0 }}
  • {{cite journal | vauthors = Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T | title = Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other | journal = Nucleic Acids Research | volume = 16 | issue = 23 | pages = 11057–74 | date = Dec 1988 | pmid = 2905047 | pmc = 338996 | doi = 10.1093/nar/16.23.11057 }}
  • {{cite journal | vauthors = Sawaya BE, Rohr O, Aunis D, Schaeffer E | title = Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 23572–6 | date = Sep 1996 | pmid = 8798567 | doi = 10.1074/jbc.271.38.23572 }}
  • {{cite journal | vauthors = Rohr O, Aunis D, Schaeffer E | title = COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 49 | pages = 31149–55 | date = Dec 1997 | pmid = 9388268 | doi = 10.1074/jbc.272.49.31149 }}
  • {{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi = 10.1128/mcb.19.5.3383}}
  • {{cite journal | vauthors = Klinge CM, Kaur K, Swanson HI | title = The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 | journal = Archives of Biochemistry and Biophysics | volume = 373 | issue = 1 | pages = 163–74 | date = Jan 2000 | pmid = 10620335 | doi = 10.1006/abbi.1999.1552 }}
  • {{cite journal | vauthors = Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E | title = The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2654–60 | date = Jan 2000 | pmid = 10644726 | doi = 10.1074/jbc.275.4.2654 }}
  • {{cite journal | vauthors = Sugiyama T, Wang JC, Scott DK, Granner DK | title = Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene | journal = The Journal of Biological Chemistry | volume = 275 | issue = 5 | pages = 3446–54 | date = Feb 2000 | pmid = 10652338 | doi = 10.1074/jbc.275.5.3446 }}
  • {{cite journal | vauthors = Vlahou A, Flytzanis CN | title = Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle | journal = Developmental Biology | volume = 218 | issue = 2 | pages = 284–98 | date = Feb 2000 | pmid = 10656770 | doi = 10.1006/dbio.1999.9456 }}
  • {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}
  • {{cite journal | vauthors = Gay F, Anglade I, Gong Z, Salbert G | title = The LIM/homeodomain protein islet-1 modulates estrogen receptor functions | journal = Molecular Endocrinology | volume = 14 | issue = 10 | pages = 1627–48 | date = Oct 2000 | pmid = 11043578 | doi = 10.1210/me.14.10.1627 }}
  • {{cite journal | vauthors = You M, Fischer M, Cho WK, Crabb D | title = Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors | journal = Archives of Biochemistry and Biophysics | volume = 398 | issue = 1 | pages = 79–86 | date = Feb 2002 | pmid = 11811951 | doi = 10.1006/abbi.2001.2713 }}
  • {{cite journal | vauthors = Lin F, Kolluri SK, Chen GQ, Zhang XK | title = Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21414–22 | date = Jun 2002 | pmid = 11934895 | doi = 10.1074/jbc.M201885200 }}
  • {{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}
  • {{cite journal | vauthors = Yu X, Mertz JE | title = Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1 | journal = Journal of Virology | volume = 77 | issue = 4 | pages = 2489–99 | date = Feb 2003 | pmid = 12551987 | pmc = 141100 | doi = 10.1128/JVI.77.4.2489-2499.2003 }}
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2 : Intracellular receptors|Transcription factors
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