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词条 CREB1
释义

  1. See also

  2. Interactions

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.[1][2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[3]

See also

  • CREB

Interactions

CREB1 has been shown to interact with:

  • {{SWL|target=CEBPB|type=PPI}},[4]
  • {{SWL|target=CREB binding protein|type=PPI}},[5][6][7][8][9][10][11][12][13][14]
  • {{SWL|target=FHL2|type=PPI}},[15]
  • {{SWL|target=FHL3|type=PPI}},[15]
  • {{SWL|target=FHL5|type=PPI}}.[15]
  • {{SWL|target=HTATIP|type=PPI}},[16]
  • {{SWL|target=P53|type=PPI}},[11] and
  • {{SWL|target=RPS6KA5|type=PPI}}.[17][18]

References

1. ^{{cite journal | vauthors = Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF | title = Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA | journal = Science | volume = 242 | issue = 4884 | pages = 1430–3 | date = Dec 1988 | pmid = 2974179 | doi = 10.1126/science.2974179 }}
2. ^{{cite journal | vauthors = Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ | title = Assignment of the human gene for CREB1 to chromosome 2q32.3-q34 | journal = Genomics | volume = 7 | issue = 3 | pages = 416–21 | date = Jul 1990 | pmid = 2142119 | doi = 10.1016/0888-7543(90)90176-U }}
3. ^{{cite web | title = Entrez Gene: CREB1 cAMP responsive element binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385| accessdate = }}
4. ^{{cite journal | vauthors = Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB | title = Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta | journal = Molecular and Cellular Biology | volume = 23 | issue = 12 | pages = 4066–82 | date = Jun 2003 | pmid = 12773552 | pmc = 156132 | doi = 10.1128/MCB.23.12.4066-4082.2003 }}
5. ^{{cite journal | vauthors = Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS | title = Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 16 | pages = 5898–903 | date = Apr 2004 | pmid = 15073328 | pmc = 395895 | doi = 10.1073/pnas.0307718101 }}
6. ^{{cite journal | vauthors = Kim J, Jia L, Stallcup MR, Coetzee GA | title = The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus | journal = Journal of Molecular Endocrinology | volume = 34 | issue = 1 | pages = 107–18 | date = Feb 2005 | pmid = 15691881 | doi = 10.1677/jme.1.01701 }}
7. ^{{cite journal | vauthors = Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M | title = Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 17957–60 | date = Jul 1996 | pmid = 8663317 | doi = 10.1074/jbc.271.30.17957 }}
8. ^{{cite journal | vauthors = Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE|authorlink4=Jane Dyson | title = Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions | journal = Cell | volume = 91 | issue = 6 | pages = 741–52 | date = Dec 1997 | pmid = 9413984 | doi = 10.1016/S0092-8674(00)80463-8 }}
9. ^{{cite journal | vauthors = Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S | title = CBP alleviates the intramolecular inhibition of ATF-2 function | journal = The Journal of Biological Chemistry | volume = 273 | issue = 44 | pages = 29098–105 | date = Oct 1998 | pmid = 9786917 | doi = 10.1074/jbc.273.44.29098 }}
10. ^{{cite journal | vauthors = Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE | title = Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 42241–8 | date = Nov 2002 | pmid = 12196545 | doi = 10.1074/jbc.M207361200 }}
11. ^1 {{cite journal | vauthors = Giebler HA, Lemasson I, Nyborg JK | title = p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation | journal = Molecular and Cellular Biology | volume = 20 | issue = 13 | pages = 4849–58 | date = Jul 2000 | pmid = 10848610 | pmc = 85936 | doi = 10.1128/MCB.20.13.4849-4858.2000 }}
12. ^{{cite journal | vauthors = Zhang Q, Vo N, Goodman RH | title = Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB | journal = Molecular and Cellular Biology | volume = 20 | issue = 14 | pages = 4970–8 | date = Jul 2000 | pmid = 10866654 | pmc = 85947 | doi = 10.1128/MCB.20.14.4970-4978.2000 }}
13. ^{{cite journal | vauthors = Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ | title = MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein | journal = Molecular and Cellular Biology | volume = 21 | issue = 7 | pages = 2249–58 | date = Apr 2001 | pmid = 11259575 | pmc = 86859 | doi = 10.1128/MCB.21.7.2249-2258.2001 }}
14. ^{{cite journal | vauthors = Ledo F, Kremer L, Mellström B, Naranjo JR | title = Ca2+-dependent block of CREB-CBP transcription by repressor DREAM | journal = The EMBO Journal | volume = 21 | issue = 17 | pages = 4583–92 | date = Sep 2002 | pmid = 12198160 | pmc = 126180 | doi = 10.1093/emboj/cdf440 }}
15. ^1 2 {{cite journal | vauthors = Fimia GM, De Cesare D, Sassone-Corsi P | title = A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM | journal = Molecular and Cellular Biology | volume = 20 | issue = 22 | pages = 8613–22 | date = Nov 2000 | pmid = 11046156 | pmc = 102166 | doi = 10.1128/MCB.20.22.8613-8622.2000 }}
16. ^{{cite journal | vauthors = Gavaravarapu S, Kamine J | title = Tip60 inhibits activation of CREB protein by protein kinase A | journal = Biochemical and Biophysical Research Communications | volume = 269 | issue = 3 | pages = 758–66 | date = Mar 2000 | pmid = 10720489 | doi = 10.1006/bbrc.2000.2358 }}
17. ^{{cite journal | vauthors = Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = The EMBO Journal | volume = 17 | issue = 15 | pages = 4426–41 | date = Aug 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}
18. ^{{cite journal | vauthors = Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG | title = Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase | journal = The EMBO Journal | volume = 20 | issue = 16 | pages = 4370–9 | date = Aug 2001 | pmid = 11500364 | pmc = 125559 | doi = 10.1093/emboj/20.16.4370 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Don J, Stelzer G | title = The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis | journal = Molecular and Cellular Endocrinology | volume = 187 | issue = 1-2 | pages = 115–24 | date = Feb 2002 | pmid = 11988318 | doi = 10.1016/S0303-7207(01)00696-7 }}
  • {{cite journal | vauthors = Pandey SC | title = The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction | journal = Pharmacology & Therapeutics | volume = 104 | issue = 1 | pages = 47–58 | date = Oct 2004 | pmid = 15500908 | doi = 10.1016/j.pharmthera.2004.08.002 }}
  • {{cite journal | vauthors = Wu H, Zhou Y, Xiong ZQ | title = Transducer of regulated CREB and late phase long-term synaptic potentiation | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3218–23 | date = Jul 2007 | pmid = 17565597 | doi = 10.1111/j.1742-4658.2007.05891.x }}
  • {{cite journal | vauthors = Kitagawa K | title = CREB and cAMP response element-mediated gene expression in the ischemic brain | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3210–7 | date = Jul 2007 | pmid = 17565598 | doi = 10.1111/j.1742-4658.2007.05890.x }}
  • {{cite journal | vauthors = Takemori H, Kajimura J, Okamoto M | title = TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3202–9 | date = Jul 2007 | pmid = 17565599 | doi = 10.1111/j.1742-4658.2007.05889.x }}
  • {{cite journal | vauthors = Siu YT, Jin DY | title = CREB--a real culprit in oncogenesis | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3224–32 | date = Jul 2007 | pmid = 17565603 | doi = 10.1111/j.1742-4658.2007.05884.x }}
{{refend}}

External links

  • {{MeshName|CREB1+protein,+human}}
  • {{UCSC gene info|CREB1}}
{{NLM content}}{{PDB Gallery|geneid=1385}}{{Transcription factors|g1}}{{gene-2-stub}}

1 : Transcription factors
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