请输入您要查询的百科知识：

　

词条 CREB-binding protein
释义

  1. Function

  2. Posttranslational modification

  3. Clinical significance

  4. Small molecule inhibition

  5. Interactions

  6. References

  7. Further reading

  8. External links

{{see also|p300-CBP coactivator family}}{{Infobox_gene}}CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.[1][2]

The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.[3][4]

Function

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity [5] and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high-sequence similarity with protein EP300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.[6] Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation,[7]

Posttranslational modification

Homeodomain interacting protein kinase 2 (HIPK2) phosphorylates several regions of CBP close to the N-terminal and close to the C-terminal region as well. Out of the described phosphoacceptor sites, serines 2361, 2363, 2371, 2376, and 2381 are responsible for the HIPK2-induced mobility shift of the CBP C-terminal activation domain that is also visible in poly-acrylamide gel electrophoresis (PAGE) experiments. However, activation of CBP by HIPK2 is not mediated by this phosphorylation but rather by counteracting the repressive action of the cell cycle regulatory domain 1 (CRD1) of CBP, located between amino acids 977 and 1076.[8]

Clinical significance

Mutations in this gene cause Rubinstein-Taybi syndrome (RTS).[9] Chromosomal translocations involving this gene have been associated with acute myeloid leukemia.[6][10] Hypothalamic expression of this gene in mice correlates with mouse lifespan, and when CBP is inhibited in C. elegans by RNAi, there is a proportional fold-change decrease in lifespan.

Small molecule inhibition

A small molecule inhibitor (I-CBP112) binding to the bromodomain domain of CBP/p300 has been developed for leukemia therapy.[11]

Interactions

CREB-binding protein has been shown to interact with:

{{div col|colwidth=20em}}
  • TF2,[12]
  • AR,[14][13][14][15]
  • AIRE,[16][17]
  • BRCA1,[20][18][19][20][21]
  • C-jun,[12]
  • CSK,[22]
  • Ccaat-enhancer-binding proteins,[23]
  • CDX2,[24]
  • CREB1,[12][25][26][27][28][29][30][31][32][33]
  • CSNK2A2,[34]
  • CUTL1,[35]
  • CSNK2A1,[34]
  • CDK8,[42]
  • EBF1,[36]
  • EVI1,[37]
  • ESR1,[38][46]
  • FOXO1,[39]
  • GLI3,[40]
  • GTF2B,[38][50]
  • HIF1A,[41][42][43]
  • HIPK2,[44]
  • HNF1A,[45]
  • HOXB7,[46]
  • HNF4A,[47][48]
  • ING1,[49]
  • KHDRBS1,[50]
  • KLF13,[51]
  • KLF4,[52]
  • Ku70,[53]
  • MAF,[54]
  • MLL,[32][55]
  • MSX1,[56]
  • MYBL2,[68]
  • MYB,[29][57]
  • MyoD,[58][59]
  • NCOA1,[60][74]
  • NCOA3,[61][62]
  • NCOA6,[63][64]
  • NEUROG1,[79]
  • NFATC4,[65]
  • NFE2L2,[66]
  • NFE2,[67]
  • NR3C1,[68]
  • NUP98,[69]
  • P53,[30][70][71]
  • PCAF,[72][73]
  • POLR2A,[72]
  • PPARGC1A,[74]
  • PTMA,[75]
  • PML,[76][77][78]
  • RBBP4,[31]
  • RELA,[15][79][80][81][82]
  • RPS6KA3,[83]
  • SERTAD1,[84]
  • SMARCA4,[21][85]
  • SMAD1,[86][87]
  • SMARCB1[72]
  • SREBF1,[109]
  • SREBF2,[88]
  • SS18L1,[89]
  • STAT1,[90]
  • STAT2,[91]
  • STAT6,[92][93]
  • SRF,[76]
  • TCF3,[94]
  • TGS1,[95]
  • TRERF1,[96]
  • TDG,[73] and
  • Zif268.[97]
{{Div col end}}{{Clear}}

References

1. ^{{cite journal | vauthors = Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH | title = Phosphorylated CREB binds specifically to the nuclear protein CBP | journal = Nature | volume = 365 | issue = 6449 | pages = 855–9 | date = October 1993 | pmid = 8413673 | doi = 10.1038/365855a0 | bibcode = 1993Natur.365..855C }}
2. ^{{cite journal | vauthors = Wydner KL, Bhattacharya S, Eckner R, Lawrence JB, Livingston DM | title = Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization | journal = Genomics | volume = 30 | issue = 2 | pages = 395–6 | date = November 1995 | pmid = 8586450 | doi = }}
3. ^{{cite journal | vauthors = Teufel DP, Freund SM, Bycroft M, Fersht AR | title = Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 17 | pages = 7009–14 | date = April 2007 | pmid = 17438265 | pmc = 1855428 | doi = 10.1073/pnas.0702010104 | bibcode = 2007PNAS..104.7009T }};{{cite journal | vauthors = Piskacek S, Gregor M, Nemethova M, Grabner M, Kovarik P, Piskacek M | title = Nine-amino-acid transactivation domain: establishment and prediction utilities | journal = Genomics | volume = 89 | issue = 6 | pages = 756–68 | date = June 2007 | pmid = 17467953 | doi = 10.1016/j.ygeno.2007.02.003 }};{{cite journal | vauthors = Piskacek M | title = 9aaTAD is a common transactivation domain recruits multiple general coactivators TAF9, MED15, CBP/p300 and GCN5 | journal = Nature Precedings | url = | doi = 10.1038/npre.2009.3488.2 | date= 2009-11-05}};{{cite journal | vauthors = Piskacek M | title = 9aaTADs mimic DNA to interact with a pseudo-DNA Binding Domain KIX of Med15 (Molecular Chameleons) | journal = Nature Precedings | url = | doi = 10.1038/npre.2009.3939.1 | date= 2009-11-05}};{{cite journal | vauthors = Piskacek M | title = 9aaTAD Prediction result (2006) | journal = Nature Precedings | url = | doi = 10.1038/npre.2009.3984.1 | date= 2009-11-20 }}
4. ^The prediction for 9aaTADs (for both acidic and hydrophilic transactivation domains) is available online from ExPASy http://us.expasy.org/tools/ and EMBnet Spain http://www.es.embnet.org/Services/EMBnetAT/htdoc/9aatad/{{dead link|date=November 2016 |bot=InternetArchiveBot |fix-attempted=yes }}
5. ^{{cite journal | vauthors = Ogryzko VV et al | year = 1996 | title = The transcriptional coactivators p300 and CBP are histone acetyltransferases | url = | journal = Cell | volume = 87 | issue = 5| pages = 953–9 | pmid = 8945521 | doi=10.1016/s0092-8674(00)82001-2}}
6. ^1 {{cite web | title = Entrez Gene: CREBBP (CREB-binding protein) | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1387 | accessdate = }}
7. ^{{cite journal | vauthors = Siddique H, Rao VN, Reddy ES | title = CBP-mediated post-translational N-glycosylation of BRCA2 | journal = International Journal of Oncology | volume = 35 | issue = 2 | pages = 387–91 | date = August 2009 | pmid = 19578754 | pmc = | doi = 10.3892/ijo_00000351 }}
8. ^{{cite journal | vauthors = Kovacs KA, Steinmann M, Halfon O, Magistretti PJ, Cardinaux JR | title = Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2 | journal = Cell Signaling | volume = 27 | issue = 11 | pages = 2252–60 | date = Nov 2015 | pmid = 26247811 | doi = 10.1016/j.cellsig.2015.08.001 }}
9. ^{{cite journal | vauthors = Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ | title = Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP | journal = Nature | volume = 376 | issue = 6538 | pages = 348–51 | date = July 1995 | pmid = 7630403 | doi = 10.1038/376348a0 | bibcode = 1995Natur.376..348P }}
10. ^{{cite journal | vauthors = Vizmanos JL, Larráyoz MJ, Lahortiga I, Floristán F, Alvarez C, Odero MD, Novo FJ, Calasanz MJ | title = t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia | journal = Genes, Chromosomes & Cancer | volume = 36 | issue = 4 | pages = 402–5 | date = April 2003 | pmid = 12619164 | doi = 10.1002/gcc.10174 }}
11. ^{{cite journal | vauthors = Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S | title = Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy | journal = Cancer Research | volume = 75 | issue = 23 | pages = 5106–19 | date = December 2015 | pmid = 26552700 | pmc = 4948672 | doi = 10.1158/0008-5472.CAN-15-0236 }}
12. ^1 2 {{cite journal | vauthors = Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S | title = CBP alleviates the intramolecular inhibition of ATF-2 function | journal = The Journal of Biological Chemistry | volume = 273 | issue = 44 | pages = 29098–105 | date = October 1998 | pmid = 9786917 | doi = 10.1074/jbc.273.44.29098 }}
13. ^{{cite journal | vauthors = Frønsdal K, Engedal N, Slagsvold T, Saatcioglu F | title = CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 48 | pages = 31853–9 | date = November 1998 | pmid = 9822653 | doi = 10.1074/jbc.273.48.31853 }}
14. ^{{cite journal | vauthors = Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S | title = p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 3 | pages = 660–5 | date = July 2003 | pmid = 12810069 | doi = 10.1016/S0006-291X(03)01021-0 }}
15. ^1 {{cite journal | vauthors = Aarnisalo P, Palvimo JJ, Jänne OA | title = CREB-binding protein in androgen receptor-mediated signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 5 | pages = 2122–7 | date = March 1998 | pmid = 9482849 | pmc = 19270 | doi = 10.1073/pnas.95.5.2122 | bibcode = 1998PNAS...95.2122A }}
16. ^{{cite journal | vauthors = Pitkänen J, Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott HS, Antonarakis SE, Kudoh J, Shimizu N, Krohn K, Peterson P | title = The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 16802–9 | date = June 2000 | pmid = 10748110 | doi = 10.1074/jbc.M908944199 }}
17. ^{{cite journal | vauthors = Iioka T, Furukawa K, Yamaguchi A, Shindo H, Yamashita S, Tsukazaki T | title = P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain | journal = Journal of Bone and Mineral Research | volume = 18 | issue = 8 | pages = 1419–29 | date = August 2003 | pmid = 12929931 | doi = 10.1359/jbmr.2003.18.8.1419 }}
18. ^{{cite journal | vauthors = Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM | title = CBP/p300 interact with and function as transcriptional coactivators of BRCA1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 3 | pages = 1020–5 | date = February 2000 | pmid = 10655477 | pmc = 15508 | doi = 10.1073/pnas.97.3.1020 | bibcode = 2000PNAS...97.1020P }}
19. ^{{cite journal | vauthors = Chai YL, Cui J, Shao N, Shyam E, Reddy P, Rao VN | title = The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter | journal = Oncogene | volume = 18 | issue = 1 | pages = 263–8 | date = January 1999 | pmid = 9926942 | doi = 10.1038/sj.onc.1202323 }}
20. ^{{cite journal | vauthors = Benezra M, Chevallier N, Morrison DJ, MacLachlan TK, El-Deiry WS, Licht JD | title = BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26333–41 | date = July 2003 | pmid = 12700228 | doi = 10.1074/jbc.M303076200 }}
21. ^1 {{cite journal | vauthors = Neish AS, Anderson SF, Schlegel BP, Wei W, Parvin JD | title = Factors associated with the mammalian RNA polymerase II holoenzyme | journal = Nucleic Acids Research | volume = 26 | issue = 3 | pages = 847–53 | date = February 1998 | pmid = 9443979 | pmc = 147327 | doi = 10.1093/nar/26.3.847 }}
22. ^{{cite journal | vauthors = Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M | title = Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases | journal = Nature | volume = 404 | issue = 6781 | pages = 999–1003 | date = April 2000 | pmid = 10801129 | doi = 10.1038/35010121 }}
23. ^{{cite journal | vauthors = Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR | title = CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36959–65 | date = September 2003 | pmid = 12857754 | doi = 10.1074/jbc.M303147200 }}
24. ^{{cite journal | vauthors = Lorentz O, Suh ER, Taylor JK, Boudreau F, Traber PG | title = CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 11 | pages = 7196–9 | date = March 1999 | pmid = 10066780 | doi = 10.1074/jbc.274.11.7196 }}
25. ^1 {{cite journal | vauthors = Kim J, Jia L, Stallcup MR, Coetzee GA | title = The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus | journal = Journal of Molecular Endocrinology | volume = 34 | issue = 1 | pages = 107–18 | date = February 2005 | pmid = 15691881 | doi = 10.1677/jme.1.01701 }}
26. ^{{cite journal | vauthors = Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS | title = Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 16 | pages = 5898–903 | date = April 2004 | pmid = 15073328 | pmc = 395895 | doi = 10.1073/pnas.0307718101 | bibcode = 2004PNAS..101.5898S }}
27. ^{{cite journal | vauthors = Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M | title = Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 17957–60 | date = July 1996 | pmid = 8663317 | doi = 10.1074/jbc.271.30.17957 }}
28. ^{{cite journal | vauthors = Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE |authorlink4=Jane Dyson| title = Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions | journal = Cell | volume = 91 | issue = 6 | pages = 741–52 | date = December 1997 | pmid = 9413984 | doi = 10.1016/S0092-8674(00)80463-8 }}
29. ^1 {{cite journal | vauthors = Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE | title = Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 42241–8 | date = November 2002 | pmid = 12196545 | doi = 10.1074/jbc.M207361200 }}
30. ^1 {{cite journal | vauthors = Giebler HA, Lemasson I, Nyborg JK | title = p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation | journal = Molecular and Cellular Biology | volume = 20 | issue = 13 | pages = 4849–58 | date = July 2000 | pmid = 10848610 | pmc = 85936 | doi = 10.1128/MCB.20.13.4849-4858.2000 }}
31. ^1 {{cite journal | vauthors = Zhang Q, Vo N, Goodman RH | title = Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB | journal = Molecular and Cellular Biology | volume = 20 | issue = 14 | pages = 4970–8 | date = July 2000 | pmid = 10866654 | pmc = 85947 | doi = 10.1128/MCB.20.14.4970-4978.2000 }}
32. ^1 {{cite journal | vauthors = Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ | title = MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein | journal = Molecular and Cellular Biology | volume = 21 | issue = 7 | pages = 2249–58 | date = April 2001 | pmid = 11259575 | pmc = 86859 | doi = 10.1128/MCB.21.7.2249-2258.2001 }}
33. ^{{cite journal | vauthors = Ledo F, Kremer L, Mellström B, Naranjo JR | title = Ca2+-dependent block of CREB-CBP transcription by repressor DREAM | journal = The EMBO Journal | volume = 21 | issue = 17 | pages = 4583–92 | date = September 2002 | pmid = 12198160 | pmc = 126180 | doi = 10.1093/emboj/cdf440 }}
34. ^1 {{cite journal | vauthors = Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H | title = Casein kinase II interacts with the bZIP domains of several transcription factors | journal = Nucleic Acids Research | volume = 26 | issue = 16 | pages = 3854–61 | date = August 1998 | pmid = 9685505 | pmc = 147779 | doi = 10.1093/nar/26.16.3854 }}
35. ^{{cite journal | vauthors = Li S, Aufiero B, Schiltz RL, Walsh MJ | title = Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 13 | pages = 7166–71 | date = June 2000 | pmid = 10852958 | pmc = 16517 | doi = 10.1073/pnas.130028697 | bibcode = 2000PNAS...97.7166L }}
36. ^{{cite journal | vauthors = Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T | title = Inhibition of p300/CBP by early B-cell factor | journal = Molecular and Cellular Biology | volume = 23 | issue = 11 | pages = 3837–46 | date = June 2003 | pmid = 12748286 | pmc = 155219 | doi = 10.1128/MCB.23.11.3837-3846.2003 }}
37. ^{{cite journal | vauthors = Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G | title = Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 44936–43 | date = November 2001 | pmid = 11568182 | doi = 10.1074/jbc.M106733200 }}
38. ^1 2 {{cite journal | vauthors = Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM | title = p300 Modulates the BRCA1 inhibition of estrogen receptor activity | journal = Cancer Research | volume = 62 | issue = 1 | pages = 141–51 | date = January 2002 | pmid = 11782371 | doi = }}
39. ^{{cite journal | vauthors = Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC | title = DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 19 | pages = 10412–7 | date = September 2000 | pmid = 10973497 | pmc = 27038 | doi = 10.1073/pnas.190326997 | bibcode = 2000PNAS...9710412N }}
40. ^{{cite journal | vauthors = Dai P, Akimaru H, Tanaka Y, Maekawa T, Nakafuku M, Ishii S | title = Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 12 | pages = 8143–52 | date = March 1999 | pmid = 10075717 | doi = 10.1074/jbc.274.12.8143 }}
41. ^{{cite journal | vauthors = Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y | title = Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 | journal = The EMBO Journal | volume = 18 | issue = 7 | pages = 1905–14 | date = April 1999 | pmid = 10202154 | pmc = 1171276 | doi = 10.1093/emboj/18.7.1905 }}
42. ^{{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = January 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}
43. ^{{cite journal | vauthors = Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H | title = Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation | journal = Molecular Pharmacology | volume = 74 | issue = 1 | pages = 236–45 | date = July 2008 | pmid = 18426857 | doi = 10.1124/mol.108.045278 }}
44. ^{{cite journal | vauthors = Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, Will H, Schmitz ML | title = Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 | journal = Nature Cell Biology | volume = 4 | issue = 1 | pages = 1–10 | date = January 2002 | pmid = 11740489 | doi = 10.1038/ncb715 }}
45. ^{{cite journal | vauthors = Soutoglou E, Papafotiou G, Katrakili N, Talianidis I | title = Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12515–20 | date = April 2000 | pmid = 10777539 | doi = 10.1074/jbc.275.17.12515 }}
46. ^{{cite journal | vauthors = Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V | title = CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein | journal = Oncogene | volume = 18 | issue = 27 | pages = 4007–14 | date = July 1999 | pmid = 10435624 | doi = 10.1038/sj.onc.1202776 }}
47. ^{{cite journal | vauthors = Yoshida E, Aratani S, Itou H, Miyagishi M, Takiguchi M, Osumu T, Murakami K, Fukamizu A | title = Functional association between CBP and HNF4 in trans-activation | journal = Biochemical and Biophysical Research Communications | volume = 241 | issue = 3 | pages = 664–9 | date = December 1997 | pmid = 9434765 | doi = 10.1006/bbrc.1997.7871 }}
48. ^{{cite journal | vauthors = Dell H, Hadzopoulou-Cladaras M | title = CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 9013–21 | date = March 1999 | pmid = 10085149 | doi = 10.1074/jbc.274.13.9013 }}
49. ^{{cite journal | vauthors = Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K | title = Human ING1 proteins differentially regulate histone acetylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29832–9 | date = August 2002 | pmid = 12015309 | doi = 10.1074/jbc.M200197200 }}
50. ^{{cite journal | vauthors = Hong W, Resnick RJ, Rakowski C, Shalloway D, Taylor SJ, Blobel GA | title = Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68 | journal = Molecular Cancer Research | volume = 1 | issue = 1 | pages = 48–55 | date = November 2002 | pmid = 12496368 | doi = }}
51. ^{{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = March 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }}
52. ^{{cite journal | vauthors = Geiman DE, Ton-That H, Johnson JM, Yang VW | title = Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction | journal = Nucleic Acids Research | volume = 28 | issue = 5 | pages = 1106–13 | date = March 2000 | pmid = 10666450 | pmc = 102607 | doi = 10.1093/nar/28.5.1106 }}
53. ^{{cite journal | vauthors = Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL | title = Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex | journal = Molecular and Cellular Biology | volume = 18 | issue = 3 | pages = 1349–58 | date = March 1998 | pmid = 9488450 | pmc = 108848 | doi = 10.1128/mcb.18.3.1349 }}
54. ^{{cite journal | vauthors = Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA | title = CREB-binding protein/p300 co-activation of crystallin gene expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 27 | pages = 24081–9 | date = July 2002 | pmid = 11943779 | doi = 10.1074/jbc.M201821200 }}
55. ^{{cite journal | vauthors = Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE | title = Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43168–74 | date = November 2002 | pmid = 12205094 | doi = 10.1074/jbc.M207660200 }}
56. ^{{cite journal | vauthors = Shetty S, Takahashi T, Matsui H, Ayengar R, Raghow R | title = Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300) | journal = The Biochemical Journal | volume = 339 | issue = 3 | pages = 751–8 | date = May 1999 | pmid = 10215616 | pmc = 1220213 | doi = 10.1042/0264-6021:3390751 }}
57. ^1 {{cite journal | vauthors = Bessa M, Saville MK, Watson RJ | title = Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator | journal = Oncogene | volume = 20 | issue = 26 | pages = 3376–86 | date = June 2001 | pmid = 11423988 | doi = 10.1038/sj.onc.1204439 }}
58. ^{{cite journal | vauthors = Polesskaya A, Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A | title = Interaction between acetylated MyoD and the bromodomain of CBP and/or p300 | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5312–20 | date = August 2001 | pmid = 11463815 | pmc = 87255 | doi = 10.1128/MCB.21.16.5312-5320.2001 }}
59. ^{{cite journal | vauthors = Sartorelli V, Huang J, Hamamori Y, Kedes L | title = Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C | journal = Molecular and Cellular Biology | volume = 17 | issue = 2 | pages = 1010–26 | date = February 1997 | pmid = 9001254 | pmc = 231826 | doi = 10.1128/mcb.17.2.1010 }}
60. ^1 {{cite journal | vauthors = Sheppard HM, Harries JC, Hussain S, Bevan C, Heery DM | title = Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1 | journal = Molecular and Cellular Biology | volume = 21 | issue = 1 | pages = 39–50 | date = January 2001 | pmid = 11113179 | pmc = 86566 | doi = 10.1128/MCB.21.1.39-50.2001 }}
61. ^1 {{cite journal | vauthors = Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW | title = Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase | journal = Molecular and Cellular Biology | volume = 22 | issue = 10 | pages = 3549–61 | date = May 2002 | pmid = 11971985 | pmc = 133790 | doi = 10.1128/MCB.22.10.3549-3561.2002 }}
62. ^{{cite journal | vauthors = Naltner A, Wert S, Whitsett JA, Yan C | title = Temporal/spatial expression of nuclear receptor coactivators in the mouse lung | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 279 | issue = 6 | pages = L1066-74 | date = December 2000 | pmid = 11076796 | doi = 10.1152/ajplung.2000.279.6.l1066}}
63. ^{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34283–93 | date = November 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 }}
64. ^{{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Molecular Endocrinology | volume = 15 | issue = 2 | pages = 241–54 | date = February 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 }}
65. ^{{cite journal | vauthors = Yang T, Davis RJ, Chow CW | title = Requirement of two NFATc4 transactivation domains for CBP potentiation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39569–76 | date = October 2001 | pmid = 11514544 | doi = 10.1074/jbc.M102961200 }}
66. ^{{cite journal | vauthors = Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, Yamamoto M | title = Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription | journal = Genes to Cells | volume = 6 | issue = 10 | pages = 857–68 | date = October 2001 | pmid = 11683914 | doi = 10.1046/j.1365-2443.2001.00469.x }}
67. ^{{cite journal | vauthors = Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA | title = Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 14 | pages = 10715–21 | date = April 2001 | pmid = 11154691 | doi = 10.1074/jbc.M007846200 }}
68. ^{{cite journal | vauthors = Almlöf T, Wallberg AE, Gustafsson JA, Wright AP | title = Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors | journal = Biochemistry | volume = 37 | issue = 26 | pages = 9586–94 | date = June 1998 | pmid = 9649342 | doi = 10.1021/bi973029x }}
69. ^{{cite journal | vauthors = Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM | title = CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 764–76 | date = January 1999 | pmid = 9858599 | pmc = 83933 | doi = 10.1128/mcb.19.1.764}}
70. ^{{cite journal | vauthors = Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, Yao TP | title = MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation | journal = The EMBO Journal | volume = 21 | issue = 22 | pages = 6236–45 | date = November 2002 | pmid = 12426395 | pmc = 137207 | doi = 10.1093/emboj/cdf616 }}
71. ^{{cite journal | vauthors = Livengood JA, Scoggin KE, Van Orden K, McBryant SJ, Edayathumangalam RS, Laybourn PJ, Nyborg JK | title = p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9054–61 | date = March 2002 | pmid = 11782467 | doi = 10.1074/jbc.M108870200 }}
72. ^1 2 3 {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5355–63 | date = September 1998 | pmid = 9710619 | pmc = 109120 | doi = }}
73. ^1 2 {{cite journal | vauthors = Tini M, Benecke A, Um SJ, Torchia J, Evans RM, Chambon P | title = Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription | journal = Molecular Cell | volume = 9 | issue = 2 | pages = 265–77 | date = February 2002 | pmid = 11864601 | doi = 10.1016/S1097-2765(02)00453-7 }}
74. ^{{cite journal | vauthors = Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM | title = Activation of PPARgamma coactivator-1 through transcription factor docking | journal = Science | volume = 286 | issue = 5443 | pages = 1368–71 | date = November 1999 | pmid = 10558993 | doi = 10.1126/science.286.5443.1368 }}
75. ^{{cite journal | vauthors = Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T | title = Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription | journal = EMBO Reports | volume = 3 | issue = 4 | pages = 361–6 | date = April 2002 | pmid = 11897665 | pmc = 1084059 | doi = 10.1093/embo-reports/kvf071 }}
76. ^1 {{cite journal | vauthors = Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagahiro S, Saya H, Nakao M | title = PML-nuclear bodies are involved in cellular serum response | journal = Genes to Cells | volume = 8 | issue = 3 | pages = 275–86 | date = March 2003 | pmid = 12622724 | doi = 10.1046/j.1365-2443.2003.00632.x }}
77. ^{{cite journal | vauthors = Doucas V, Tini M, Egan DA, Evans RM | title = Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 6 | pages = 2627–32 | date = March 1999 | pmid = 10077561 | pmc = 15819 | doi = 10.1073/pnas.96.6.2627 | bibcode = 1999PNAS...96.2627D }}
78. ^{{cite journal | vauthors = Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP | title = A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins | journal = Nature Genetics | volume = 23 | issue = 3 | pages = 287–95 | date = November 1999 | pmid = 10610177 | doi = 10.1038/15463 }}
79. ^{{cite journal | vauthors = Jang HD, Yoon K, Shin YJ, Kim J, Lee SY | title = PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24873–80 | date = June 2004 | pmid = 15140884 | doi = 10.1074/jbc.M313018200 }}
80. ^{{cite journal | vauthors = Zhong H, May MJ, Jimi E, Ghosh S | title = The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 625–36 | date = March 2002 | pmid = 11931769 | doi = 10.1016/S1097-2765(02)00477-X }}
81. ^{{cite journal | vauthors = Parry GC, Mackman N | title = Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription | journal = Journal of Immunology | volume = 159 | issue = 11 | pages = 5450–6 | date = December 1997 | pmid = 9548485 | doi = }}
82. ^{{cite journal | vauthors = Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T | title = CREB-binding protein/p300 are transcriptional coactivators of p65 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 7 | pages = 2927–32 | date = April 1997 | pmid = 9096323 | pmc = 20299 | doi = 10.1073/pnas.94.7.2927 | bibcode = 1997PNAS...94.2927G }}
83. ^{{cite journal | vauthors = Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P | title = Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 7089–96 | date = October 2001 | pmid = 11564891 | pmc = 99884 | doi = 10.1128/MCB.21.20.7089-7096.2001 }}
84. ^{{cite journal | vauthors = Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T | title = Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP | journal = International Journal of Molecular Medicine | volume = 11 | issue = 6 | pages = 705–12 | date = June 2003 | pmid = 12736710 | doi = 10.3892/ijmm.11.6.705 }}
85. ^{{cite journal | vauthors = DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M | title = BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7541–9 | date = October 2000 | pmid = 11003650 | pmc = 86306 | doi = 10.1128/MCB.20.20.7541-7549.2000 }}
86. ^1 {{cite journal | vauthors = Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME | title = Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms | journal = Cell | volume = 104 | issue = 3 | pages = 365–76 | date = February 2001 | pmid = 11239394 | doi = 10.1016/S0092-8674(01)00224-0 }}
87. ^{{cite journal | vauthors = Pearson KL, Hunter T, Janknecht R | title = Activation of Smad1-mediated transcription by p300/CBP | journal = Biochimica et Biophysica Acta | volume = 1489 | issue = 2–3 | pages = 354–64 | date = December 1999 | pmid = 10673036 | doi = 10.1016/S0167-4781(99)00166-9 }}
88. ^1 {{cite journal | vauthors = Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R | title = SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein | journal = Genes & Development | volume = 10 | issue = 22 | pages = 2903–11 | date = November 1996 | pmid = 8918891 | doi = 10.1101/gad.10.22.2903 }}
89. ^{{cite journal | vauthors = Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A | title = Dendrite development regulated by CREST, a calcium-regulated transcriptional activator | journal = Science | volume = 303 | issue = 5655 | pages = 197–202 | date = January 2004 | pmid = 14716005 | doi = 10.1126/science.1089845 | bibcode = 2004Sci...303..197A }}
90. ^{{cite journal | vauthors = Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE | title = Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15092–6 | date = December 1996 | pmid = 8986769 | pmc = 26361 | doi = 10.1073/pnas.93.26.15092 | bibcode = 1996PNAS...9315092Z }}
91. ^{{cite journal | vauthors = Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM | title = Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha | journal = Nature | volume = 383 | issue = 6598 | pages = 344–7 | date = September 1996 | pmid = 8848048 | doi = 10.1038/383344a0 | bibcode = 1996Natur.383..344B }}
92. ^{{cite journal | vauthors = Litterst CM, Pfitzner E | title = Transcriptional activation by STAT6 requires the direct interaction with NCoA-1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 45713–21 | date = December 2001 | pmid = 11574547 | doi = 10.1074/jbc.M108132200 }}
93. ^{{cite journal | vauthors = McDonald C, Reich NC | title = Cooperation of the transcriptional coactivators CBP and p300 with Stat6 | journal = Journal of Interferon & Cytokine Research | volume = 19 | issue = 7 | pages = 711–22 | date = July 1999 | pmid = 10454341 | doi = 10.1089/107999099313550 }}
94. ^{{cite journal | vauthors = Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao TP, Zhuang Y | title = Regulation of E2A activities by histone acetyltransferases in B lymphocyte development | journal = The Journal of Biological Chemistry | volume = 278 | issue = 4 | pages = 2370–6 | date = January 2003 | pmid = 12435739 | doi = 10.1074/jbc.M211464200 }}
95. ^{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}
96. ^{{cite journal | vauthors = Gizard F, Lavallée B, DeWitte F, Hum DW | title = A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33881–92 | date = September 2001 | pmid = 11349124 | doi = 10.1074/jbc.M100113200 }}
97. ^{{cite journal | vauthors = Silverman ES, Du J, Williams AJ, Wadgaonkar R, Drazen JM, Collins T | title = cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1) | journal = The Biochemical Journal | volume = 336 | issue = 1 | pages = 183–9 | date = November 1998 | pmid = 9806899 | pmc = 1219856 | doi = 10.1042/bj3360183 }}

Further reading

{{refbegin | colwidth=33em}}
  • {{cite journal | vauthors = Goldman PS, Tran VK, Goodman RH | title = The multifunctional role of the co-activator CBP in transcriptional regulation | journal = Recent Progress in Hormone Research | volume = 52 | issue = | pages = 103–19; discussion 119–20 | year = 1997 | pmid = 9238849 | doi = }}
  • {{cite journal | vauthors = Marcello A, Zoppé M, Giacca M | title = Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator | journal = IUBMB Life | volume = 51 | issue = 3 | pages = 175–81 | date = March 2001 | pmid = 11547919 | doi = 10.1080/152165401753544241 }}
  • {{cite journal | vauthors = Matt T | title = Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP) | journal = Acta Medica Austriaca | volume = 29 | issue = 3 | pages = 77–9 | year = 2002 | pmid = 12168567 | doi = 10.1046/j.1563-2571.2002.02010.x }}
  • {{cite journal | vauthors = Combes R, Balls M, Bansil L, Barratt M, Bell D, Botham P, Broadhead C, Clothier R, George E, Fentem J, Jackson M, Indans I, Loizu G, Navaratnam V, Pentreath V, Phillips B, Stemplewski H, Stewart J | title = An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991) | journal = Alternatives to Laboratory Animals | volume = 30 | issue = 4 | pages = 365–406 | year = 2002 | pmid = 12234245 | doi = }}
  • {{cite journal | vauthors = Minghetti L, Visentin S, Patrizio M, Franchini L, Ajmone-Cat MA, Levi G | title = Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions | journal = Neurochemical Research | volume = 29 | issue = 5 | pages = 965–78 | date = May 2004 | pmid = 15139295 | doi = 10.1023/B:NERE.0000021241.90133.89 }}
  • {{cite journal | vauthors = Kino T, Pavlakis GN | title = Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 | journal = DNA and Cell Biology | volume = 23 | issue = 4 | pages = 193–205 | date = April 2004 | pmid = 15142377 | doi = 10.1089/104454904773819789 }}
  • {{cite journal | vauthors = Greene WC, Chen LF | title = Regulation of NF-kappaB action by reversible acetylation | journal = Novartis Foundation Symposium | volume = 259 | issue = | pages = 208–17; discussion 218–25 | year = 2004 | pmid = 15171256 | doi = 10.1002/0470862637.ch15 }}
  • {{cite journal | vauthors = Liou LY, Herrmann CH, Rice AP | title = HIV-1 infection and regulation of Tat function in macrophages | journal = The International Journal of Biochemistry & Cell Biology | volume = 36 | issue = 9 | pages = 1767–75 | date = September 2004 | pmid = 15183343 | doi = 10.1016/j.biocel.2004.02.018 }}
  • {{cite journal | vauthors = Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D | title = A review of HIV-1 Tat protein biological effects | journal = Cell Biochemistry and Function | volume = 23 | issue = 4 | pages = 223–7 | year = 2005 | pmid = 15473004 | doi = 10.1002/cbf.1147 }}
  • {{cite journal | vauthors = Bannwarth S, Gatignol A | title = HIV-1 TAR RNA: the target of molecular interactions between the virus and its host | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 61–71 | date = January 2005 | pmid = 15638724 | doi = 10.2174/1570162052772924 }}
  • {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue = | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}
  • {{cite journal | vauthors = Gibellini D, Vitone F, Schiavone P, Re MC | title = HIV-1 tat protein and cell proliferation and survival: a brief review | journal = The New Microbiologica | volume = 28 | issue = 2 | pages = 95–109 | date = April 2005 | pmid = 16035254 | doi = }}
  • {{cite journal | vauthors = Hetzer C, Dormeyer W, Schnölzer M, Ott M | title = Decoding Tat: the biology of HIV Tat posttranslational modifications | journal = Microbes and Infection / Institut Pasteur | volume = 7 | issue = 13 | pages = 1364–9 | date = October 2005 | pmid = 16046164 | doi = 10.1016/j.micinf.2005.06.003 }}
  • {{cite journal | vauthors = Peruzzi F | title = The multiple functions of HIV-1 Tat: proliferation versus apoptosis | journal = Frontiers in Bioscience | volume = 11 | issue = | pages = 708–17 | year = 2006 | pmid = 16146763 | doi = 10.2741/1829 }}
{{refend}}

External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=rsts GeneReviews/NCBI/NIH/UW entry on Rubinstein-Taybi Syndrome]
  • {{MeshName|CREBBP+protein,+human}}
  • {{NURSA|C39}}
  • Drosophila nejire - The Interactive Fly
  • {{UCSC gene info|CREBBP}}
{{NLM content}}{{PDB Gallery|geneid=1387}}{{Transcription coregulators}}{{DEFAULTSORT:Creb-Binding Protein}}

1 : Transcription coregulators
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/27 5:50:12