“Camphoric acid”的意思、由来-开放百科全书

词条

Camphoric acid

释义

History
Chemical properties and isolation
References

{{noinline|date=January 2012}}{{chembox
| Verifiedfields = changed
| verifiedrevid = 410988013
| Name = Camphoric acid
| ImageFile = Camphoric_acid.png
| ImageSize = 200px
| ImageAlt = Skeletal formula of camphoric acid
| ImageFile1 = Camphoric acid 3D ball.png
| ImageAlt1 = Ball-and-stick model of the camphoric acid molecule
| IUPACName = (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 20198
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1205405
| InChI_Ref = {{stdinchicite|correct|chemspider}}
| InChI = 1S/C10H16O4/c1-9(2)6(7(11)12)4-5-10(9,3)8(13)14/h6H,4-5H2,1-3H3,(H,11,12)(H,13,14)
| InChIKey_Ref = {{stdinchicite|correct|chemspider}}
| InChIKey = LSPHULWDVZXLIL-UHFFFAOYSA-N
| InChI1 = 1/C10H16O4/c1-9(2)6(7(11)12)4-5-10(9,3)8(13)14/h6H,4-5H2,1-3H3,(H,11,12)(H,13,14)/t6-,10+/m0/s1
| SMILES1 = O=C(O)[C@]1(CC[C@@H](C(=O)O)C1(C)C)C
| InChIKey1 = LSPHULWDVZXLIL-QUBYGPBYBH
| PubChem1 = 21491
| InChI2 = 1/C10H16O4/c1-9(2)6(7(11)12)4-5-10(9,3)8(13)14/h6H,4-5H2,1-3H3,(H,11,12)(H,13,14)
| InChIKey2 = LSPHULWDVZXLIL-UHFFFAOYAD
| SMILES2 = O=C(O)C1CCC(C(=O)O)(C)C1(C)C
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 560-09-8
| CASNo_Comment = (1S,3R)
| CASNo2 = 124-83-4
| CASNo2_Comment = (+) i.e., (1R,3S) D-Camphoric acid
}}
| Section2 = {{Chembox Properties
| C=10|H=16|O=4
| Density = 1.21 g/cm³
| MeltingPtC = 183-187
| BoilingPt =
| SolubleOther =
| Solvent =
| MagSus = -129.0·10⁻⁶ cm³/mol
}}

Camphoric acid, C₁₀H₁₆O₄ or in Latin form Acidum camphoricum, is a white crystallisable substance obtained from the oxidation of camphor. It exists in three optically different forms; the dextrorotatory one is obtained by the oxidation of dextrorotatory camphor and is used in pharmaceuticals.

History

Acidum camphoricum was studied and isolated for the first time by French pharmacist Nicolas Vauquelin in the early 19th century but it wasn't until September 1874 that Dutch chemist Jacobus H. van 't Hoff proposed the first suggestion for its molecular structure and optical properties. Haller and Blanc synthesized camphor from camphoric acid. In 1904, Finnish chemist Gustav Komppa became the first to succeed in manufacturing synthetic camphoric acid from diethyl oxalate and 3,3-dimethylpentanoic acid, and thus proving the structure of camphor.

Chemical properties and isolation

Camphoric acid may be prepared by oxidising camphor with nitric acid.

References

*{{cite web|title=Acidum camphoricum|work=The British Pharmaceutical Codex|url=http://www.henriettesherbal.com/eclectic/bpc1911/acidum-camp.html|accessdate=September 4, 2005 }}

{{cite web|title=Camphoric acid|work=Science and Technology|url=http://www.probertencyclopaedia.com/cgi-bin/res.pl?keyword=Camphoric+Acid&offset=0|accessdate=September 4, 2005 }}
{{cite web|title=Camphoric acid|work=Taiwan Tekho Camphor Co|url=http://www.camphor.com.tw/t-list.htm|accessdate=September 4, 2005 }}
{{cite journal|author=Jacobus Henricus van 't Hoff|year=1874|title=A suggestion looking to the extension into space of the structural formulas at present used in chemistry. And a note upon the relation between the optical activity and the chemical constitution of organic compounds|journal=Archives neerlandaises des sciences exactes et naturelles|volume=9|pages=445–454}}

2 : Dicarboxylic acids|Antiseptics

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。