| 词条 | CSNK1E |
| 释义 |
FunctionThe protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[3] InteractionsCSNK1E has been shown to interact with PER1[4] and AXIN1.[5] Inhibitors
References1. ^{{cite journal | vauthors = Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM | title = Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family | journal = The Journal of Biological Chemistry | volume = 270 | issue = 25 | pages = 14875–83 | date = Jun 1995 | pmid = 7797465 | pmc = | doi = 10.1074/jbc.270.25.14875 }} 2. ^{{cite journal | vauthors = Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT | title = Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 22 | pages = 12548–52 | date = Oct 1999 | pmid = 10535959 | pmc = 22983 | doi = 10.1073/pnas.96.22.12548 }} 3. ^{{cite web | title = Entrez Gene: CSNK1E casein kinase 1, epsilon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454| accessdate = }} 4. ^{{cite journal | vauthors = Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM | title = Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon | journal = Molecular and Cellular Biology | volume = 20 | issue = 13 | pages = 4888–99 | date = Jul 2000 | pmid = 10848614 | pmc = 85940 | doi = 10.1128/MCB.20.13.4888-4899.2000 }} 5. ^{{cite journal | vauthors = Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC | title = Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways | journal = The Journal of Biological Chemistry | volume = 277 | issue = 20 | pages = 17706–12 | date = May 2002 | pmid = 11884395 | doi = 10.1074/jbc.M111982200 }} External links
3 : Enzymes|Genes|Human proteins |
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