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词条 CTNNBIP1
释义

  1. Function

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}}Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.[1][2]

Function

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. The encoded protein is a negative regulator of the Wnt signaling pathway.[1]

References

1. ^1 {{cite web | title = Entrez Gene: catenin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56998| accessdate = }}
2. ^{{cite journal | vauthors = Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T | title = Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein | journal = Genes Dev. | volume = 14 | issue = 14 | pages = 1741–9 |date=July 2000 | pmid = 10898789 | pmc = 316784 | doi = | url = | issn = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Yochum GS, Cleland R, Goodman RH |title=A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. |journal=Mol. Cell. Biol. |volume=28 |issue= 24 |pages= 7368–79 |year= 2008 |pmid= 18852287 |doi= 10.1128/MCB.00744-08 |pmc=2593444}}
  • {{cite journal |vauthors=Sharma M, Henderson BR |title=IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 8545–56 |year= 2007 |pmid= 17255093 |doi= 10.1074/jbc.M610272200 }}
  • {{cite journal |vauthors=Takeda K, Kinoshita I, Shimizu Y |title=Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. |journal=BMC Cancer |volume=8 |issue= |pages= 328 |year= 2008 |pmid= 18992165 |doi= 10.1186/1471-2407-8-328 |pmc=2585585|display-authors=etal}}
  • {{cite journal |vauthors=Wang W, Zhang X, Deng K |title=ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. |journal=Cell Biochem. Funct. |volume=27 |issue= 6 |pages= 329–37 |year= 2009 |pmid= 19569129 |doi= 10.1002/cbf.1576 |display-authors=etal}}
  • {{cite journal |vauthors=Wang WJ, Tang W, Qiu ZY |title=Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages. |journal=AI Zheng |volume=28 |issue= 2 |pages= 117–21 |year= 2009 |pmid= 19550115 |doi= }}
  • {{cite journal |vauthors=Reichel O, Mayr D, Durst F, Berghaus A |title=E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux. |journal=Eur Arch Otorhinolaryngol |volume=265 |issue= 8 |pages= 937–42 |year= 2008 |pmid= 18183411 |doi= 10.1007/s00405-007-0568-6 }}
  • {{cite journal |vauthors=Bazas VM, Lukyanova NY, Demash DV |title=Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer. |journal=Exp. Oncol. |volume=30 |issue= 3 |pages= 235–9 |year= 2008 |pmid= 18806748 |doi= |display-authors=etal}}
  • {{cite journal |vauthors=Kohler EM, Chandra SH, Behrens J, Schneikert J |title=Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. |journal=Hum. Mol. Genet. |volume=18 |issue= 2 |pages= 213–26 |year= 2009 |pmid= 18854359 |doi= 10.1093/hmg/ddn338 }}
  • {{cite journal |vauthors=Seo E, Jho EH |title=Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 81–6 |year= 2007 |pmid= 17418091 |doi= 10.1016/j.bbrc.2007.03.117 }}
  • {{cite journal |vauthors=Ladeiro Y, Couchy G, Balabaud C |title=MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. |journal=Hepatology |volume=47 |issue= 6 |pages= 1955–63 |year= 2008 |pmid= 18433021 |doi= 10.1002/hep.22256 |display-authors=etal|url=http://www.hal.inserm.fr/docs/00/32/95/10/PDF/HEP-07-1716R1.pdf }}
  • {{cite journal |vauthors=Zhang H, Xue Y |title=Wnt pathway is involved in advanced gastric carcinoma. |journal=Hepatogastroenterology |volume=55 |issue= 84 |pages= 1126–30 |year= 2008|pmid= 18705344 |doi= }}
  • {{cite journal |vauthors=Wang HX, Tekpetey FR, Kidder GM |title=Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. |journal=Mol. Hum. Reprod. |volume=15 |issue= 1 |pages= 11–7 |year= 2009 |pmid= 19038973 |doi= 10.1093/molehr/gan070 }}
  • {{cite journal |vauthors=Matono H, Oda Y, Nakamori M |title=Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. |journal=Hum. Pathol. |volume=39 |issue= 12 |pages= 1802–8 |year= 2008 |pmid= 18715618 |doi= 10.1016/j.humpath.2008.05.005 |display-authors=etal}}
  • {{cite journal |vauthors=Wang L, O'Leary H, Fortney J, Gibson LF |title=Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells. |journal=Blood |volume=110 |issue= 9 |pages= 3334–44 |year= 2007 |pmid= 17638851 |doi= 10.1182/blood-2007-01-068122 |pmc=2200915}}
  • {{cite journal |vauthors=von Koch CS, Gulati M, Aldape K, Berger MS |title=Familial medulloblastoma: case report of one family and review of the literature. |journal=Neurosurgery |volume=51 |issue= 1 |pages= 227–33; discussion 233 |year= 2002 |pmid= 12182422 |doi= 10.1097/00006123-200207000-00035}}
  • {{cite journal |vauthors=Wang L, Li H, Zhang Y |title=HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. |journal=Int. J. Cancer |volume=124 |issue= 7 |pages= 1526–34 |year= 2009 |pmid= 19089909 |doi= 10.1002/ijc.24072 |pmc=2667231|display-authors=etal}}
  • {{cite journal |vauthors=Chen Y, Bodles AM |title=Amyloid precursor protein modulates beta-catenin degradation. |journal=Journal of Neuroinflammation |volume=4 |issue= |pages= 29 |year= 2007 |pmid= 18070361 |doi= 10.1186/1742-2094-4-29 |pmc=2231348}}
  • {{cite journal |vauthors=Kastritis E, Murray S, Kyriakou F |title=Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. |journal=Int. J. Cancer |volume=124 |issue= 1 |pages= 103–8 |year= 2009 |pmid= 18844223 |doi= 10.1002/ijc.23917 |display-authors=etal}}
  • {{cite journal |vauthors=Turbiner J, Moreno-Bueno G, Dahiya S |title=Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen. |journal=Mod. Pathol. |volume=21 |issue= 8 |pages= 925–36 |year= 2008 |pmid= 18500270 |doi= 10.1038/modpathol.2008.49 |display-authors=etal}}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 |pmc=1847948|display-authors=etal}}
{{refend}}

External links

  • {{MeshName|CTNNBIP1+protein,+human}}
  • {{UCSC gene info|CTNNBIP1}}
{{PDB Gallery|geneid=56998}}{{NLM content}}{{gene-1-stub}}
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