| 释义 |
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
{{Infobox_gene}}G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.[1] Function The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activty is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.[2] Clinical significance Mutations in CCND3 are implicated in cases of breast cancer.[3] Interactions Cyclin D3 has been shown to interact with: {{div col|colwidth=20em}}- AKAP8,[4]
- CDC2L1,[5]
- CDKN1B,[6][7][8]
- CRABP2,[9]
- Cyclin-dependent kinase 4,[4][6][7][8]
- Cyclin-dependent kinase 6,[7][9]
- EIF3K,[10] and
- Retinoic acid receptor alpha.[11]
{{Div col end}} See also References 1. ^{{cite journal | vauthors = Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT | title = Genomic organization, chromosomal localization, and independent expression of human cyclin D genes | journal = Genomics | volume = 13 | issue = 3 | pages = 565–74 | date = August 1992 | pmid = 1386335 | pmc = | doi = 10.1016/0888-7543(92)90126-D }}
2. ^{{cite web | title = Entrez Gene: CCND3 cyclin D3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=896| accessdate = }}
3. ^{{cite journal | title = Comprehensive molecular portraits of human breast tumours | journal = Nature | volume = 490 | issue = 7418 | pages = 61–70 | year = 2012 | pmid = 23000897 | pmc = 3465532 | doi = 10.1038/nature11412 | last1 = Koboldt | first1 = Daniel C. | last2 = Fulton | first2 = Robert S. | last3 = McLellan | first3 = Michael D. | last4 = Schmidt | first4 = Heather | last5 = Kalicki-Veizer | first5 = Joelle | last6 = McMichael | first6 = Joshua F. | last7 = Fulton | first7 = Lucinda L. | last8 = Dooling | first8 = David J. | last9 = Ding | first9 = Li | last10 = Mardis | first10 = Elaine R. | last11 = Wilson | first11 = Richard K. | last12 = Ally | first12 = Adrian | last13 = Balasundaram | first13 = Miruna | last14 = Butterfield | first14 = Yaron S. N. | last15 = Carlsen | first15 = Rebecca | last16 = Carter | first16 = Candace | last17 = Chu | first17 = Andy | last18 = Chuah | first18 = Eric | last19 = Chun | first19 = Hye-Jung E. | last20 = Coope | first20 = Robin J. N. | last21 = Dhalla | first21 = Noreen | last22 = Guin | first22 = Ranabir | last23 = Hirst | first23 = Carrie | last24 = Hirst | first24 = Martin | last25 = Holt | first25 = Robert A. | last26 = Lee | first26 = Darlene | last27 = Li | first27 = Haiyan I. | last28 = Mayo | first28 = Michael | last29 = Moore | first29 = Richard A. | last30 = Mungall | first30 = Andrew J. | displayauthors = 29 }}
4. ^1 {{cite journal | vauthors = Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I | title = A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95 | journal = Biochem. J. | volume = 378 | issue = Pt 2 | pages = 673–9 | year = 2004 | pmid = 14641107 | pmc = 1223988 | doi = 10.1042/BJ20031765 }}
5. ^{{cite journal | vauthors = Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, Chen C, Gu J | title = Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3 | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35314–22 | year = 2002 | pmid = 12082095 | doi = 10.1074/jbc.M202179200 }}
6. ^1 {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
7. ^1 2 {{cite journal | vauthors = Lin J, Jinno S, Okayama H | title = Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence | journal = Oncogene | volume = 20 | issue = 16 | pages = 2000–9 | year = 2001 | pmid = 11360184 | doi = 10.1038/sj.onc.1204375 }}
8. ^1 {{cite journal | vauthors = Zhang Q, Wang X, Wolgemuth DJ | title = Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis | journal = Endocrinology | volume = 140 | issue = 6 | pages = 2790–800 | year = 1999 | pmid = 10342870 | doi = 10.1210/endo.140.6.6756 }}
9. ^{{cite journal | vauthors = Meyerson M, Harlow E | title = Identification of G1 kinase activity for cdk6, a novel cyclin D partner | journal = Mol. Cell. Biol. | volume = 14 | issue = 3 | pages = 2077–86 | year = 1994 | pmid = 8114739 | pmc = 358568 | doi = 10.1128/MCB.14.3.2077}}
10. ^{{cite journal | vauthors = Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J | title = Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3 | journal = FEBS Lett. | volume = 573 | issue = 1–3 | pages = 139–46 | year = 2004 | pmid = 15327989 | doi = 10.1016/j.febslet.2004.07.071 }}
11. ^1 {{cite journal | vauthors = Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L | title = Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6355–62 | year = 2003 | pmid = 12482873 | doi = 10.1074/jbc.M210697200 }}
Further reading {{refbegin|2}}- {{cite journal | vauthors = Motokura T, Keyomarsi K, Kronenberg HM, Arnold A | title = Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene | journal = J. Biol. Chem. | volume = 267 | issue = 28 | pages = 20412–5 | year = 1992 | pmid = 1383201 | doi = }}
- {{cite journal | vauthors = Xiong Y, Menninger J, Beach D, Ward DC | title = Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins | journal = Genomics | volume = 13 | issue = 3 | pages = 575–84 | year = 1992 | pmid = 1386336 | doi = 10.1016/0888-7543(92)90127-E }}
- {{cite journal | vauthors = Motokura T, Yi HF, Kronenberg HM, McBride OW, Arnold A | title = Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13 | journal = Cytogenet. Cell Genet. | volume = 61 | issue = 1 | pages = 5–7 | year = 1992 | pmid = 1387066 | doi = 10.1159/000133359 }}
- {{cite journal | vauthors = Matsuoka S, Yamaguchi M, Matsukage A | title = D-type cyclin-binding regions of proliferating cell nuclear antigen | journal = J. Biol. Chem. | volume = 269 | issue = 15 | pages = 11030–6 | year = 1994 | pmid = 7908906 | doi = }}
- {{cite journal | vauthors = Meyerson M, Harlow E | title = Identification of G1 kinase activity for cdk6, a novel cyclin D partner | journal = Mol. Cell. Biol. | volume = 14 | issue = 3 | pages = 2077–86 | year = 1994 | pmid = 8114739 | pmc = 358568 | doi = 10.1128/MCB.14.3.2077}}
- {{cite journal | vauthors = Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA | title = Physical interaction of the retinoblastoma protein with human D cyclins | journal = Cell | volume = 73 | issue = 3 | pages = 499–511 | year = 1993 | pmid = 8490963 | doi = 10.1016/0092-8674(93)90137-F }}
- {{cite journal | vauthors = Brooks AR, Shiffman D, Chan CS, Brooks EE, Milner PG | title = Functional analysis of the human cyclin D2 and cyclin D3 promoters | journal = J. Biol. Chem. | volume = 271 | issue = 15 | pages = 9090–9 | year = 1996 | pmid = 8621559 | doi = 10.1074/jbc.271.15.9090 }}
- {{cite journal | vauthors = Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A | title = Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest | journal = Mol. Cell. Biol. | volume = 16 | issue = 7 | pages = 3934–44 | year = 1996 | pmid = 8668211 | pmc = 231390 | doi = 10.1128/MCB.16.7.3934}}
- {{cite journal | vauthors = Hirai H, Sherr CJ | title = Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1 | journal = Mol. Cell. Biol. | volume = 16 | issue = 11 | pages = 6457–67 | year = 1996 | pmid = 8887674 | pmc = 231647 | doi = 10.1128/MCB.16.11.6457}}
- {{cite journal | vauthors = Doglioni C, Chiarelli C, Macrí E, Dei Tos AP, Meggiolaro E, Dalla Palma P, Barbareschi M | title = Cyclin D3 expression in normal, reactive and neoplastic tissues | journal = J. Pathol. | volume = 185 | issue = 2 | pages = 159–66 | year = 1998 | pmid = 9713342 | doi = 10.1002/(SICI)1096-9896(199806)185:2<159::AID-PATH73>3.0.CO;2-0 }}
- {{cite journal | vauthors = Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA | title = Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 353–63 | year = 1999 | pmid = 9858559 | pmc = 83893 | doi = 10.1128/mcb.19.1.353}}
- {{cite journal | vauthors = Gabrielli BG, Sarcevic B, Sinnamon J, Walker G, Castellano M, Wang XQ, Ellem KA | title = A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 13961–9 | year = 1999 | pmid = 10318807 | doi = 10.1074/jbc.274.20.13961 }}
- {{cite journal | vauthors = Zhang Q, Wang X, Wolgemuth DJ | title = Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis | journal = Endocrinology | volume = 140 | issue = 6 | pages = 2790–800 | year = 1999 | pmid = 10342870 | doi = 10.1210/endo.140.6.6756 }}
- {{cite journal | vauthors = Bartkova J, Rajpert-de Meyts E, Skakkebaek NE, Bartek J | title = D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy | journal = J. Pathol. | volume = 187 | issue = 5 | pages = 573–81 | year = 1999 | pmid = 10398124 | doi = 10.1002/(SICI)1096-9896(199904)187:5<573::AID-PATH289>3.0.CO;2-H }}
- {{cite journal | vauthors = Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA | title = Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells | journal = Mol. Cell. Biol. | volume = 20 | issue = 15 | pages = 5690–9 | year = 2000 | pmid = 10891505 | pmc = 86042 | doi = 10.1128/MCB.20.15.5690-5699.2000 }}
- {{cite journal | vauthors = Sansal I, Dupont E, Toru D, Evrard C, Rouget P | title = NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity | journal = Oncogene | volume = 19 | issue = 43 | pages = 5000–9 | year = 2000 | pmid = 11042687 | doi = 10.1038/sj.onc.1203843 }}
- {{cite journal | vauthors = Fink JR, LeBien TW | title = Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors | journal = Exp. Hematol. | volume = 29 | issue = 4 | pages = 490–8 | year = 2001 | pmid = 11301189 | doi = 10.1016/S0301-472X(01)00619-1 }}
- {{cite journal | vauthors = Lin J, Jinno S, Okayama H | title = Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence | journal = Oncogene | volume = 20 | issue = 16 | pages = 2000–9 | year = 2001 | pmid = 11360184 | doi = 10.1038/sj.onc.1204375 }}
- {{cite journal | vauthors = Bartkova J, Thullberg M, Slezak P, Jaramillo E, Rubio C, Thomassen LH, Bartek J | title = Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon | journal = Gastroenterology | volume = 120 | issue = 7 | pages = 1680–8 | year = 2001 | pmid = 11375949 | doi = 10.1053/gast.2001.24880 }}
{{refend}}{{Cell cycle proteins}} |