| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene.[1]The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.[2] Interactions Cyclin-dependent kinase 7 has been shown to interact with: {{div col|colwidth=20em}}- Androgen receptor,[3]
- Cyclin H,[4][4][5]
- GTF2H1,[7][4][6]
- MNAT1,[4][7]
- P53,[8][9]
- SUPT5H,[5] and
- XPB.[10][11][12]
{{Div col end}} See also - Cyclin-dependent kinase
- CDK7 pathway
References 1. ^{{cite journal | vauthors = Fisher RP, Morgan DO | title = A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase | journal = Cell | volume = 78 | issue = 4 | pages = 713–24 | date = Aug 1994 | pmid = 8069918 | pmc = | doi = 10.1016/0092-8674(94)90535-5 }}
2. ^{{cite web | title = Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1022| accessdate = }}
3. ^{{cite journal | vauthors = Lee DK, Duan HO, Chang C | title = From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9308–13 | date = Mar 2000 | pmid = 10734072 | doi = 10.1074/jbc.275.13.9308}}
4. ^{{cite journal | vauthors = Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA | title = A cyclin associated with the CDK-activating kinase MO15 | journal = Nature | volume = 371 | issue = 6494 | pages = 254–7 | date = Sep 1994 | pmid = 8078587 | doi = 10.1038/371254a0 }}
5. ^1 {{cite journal | vauthors = Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA | title = CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA | journal = Molecular and Cellular Biology | volume = 20 | issue = 18 | pages = 6958–69 | date = Sep 2000 | pmid = 10958691 | pmc = 88771 | doi = 10.1128/mcb.20.18.6958-6969.2000}}
6. ^{{cite journal | vauthors = Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D | title = Cdk-activating kinase complex is a component of human transcription factor TFIIH | journal = Nature | volume = 374 | issue = 6519 | pages = 283–7 | date = Mar 1995 | pmid = 7533895 | doi = 10.1038/374283a0 }}
7. ^{{cite journal | vauthors = Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R | title = MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11676–85 | date = Mar 2003 | pmid = 12527756 | doi = 10.1074/jbc.M209570200 }}
8. ^{{cite journal | vauthors = Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ | title = p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7220–9 | date = Dec 1997 | pmid = 9372954 | pmc = 232579 | doi = 10.1128/mcb.17.12.7220}}
9. ^{{cite journal | vauthors = Schneider E, Montenarh M, Wagner P | title = Regulation of CAK kinase activity by p53 | journal = Oncogene | volume = 17 | issue = 21 | pages = 2733–41 | date = Nov 1998 | pmid = 9840937 | doi = 10.1038/sj.onc.1202504 }}
10. ^{{cite journal | vauthors = Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W | title = A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A | journal = Nature Genetics | volume = 36 | issue = 7 | pages = 714–9 | date = Jul 2004 | pmid = 15220921 | doi = 10.1038/ng1387 | author16 = Vermeulen Wim | author14 = Aebersold Ruedi | author15 = Hoeijmakers Jan H J | author13 = Egly Jean-Marc }}
11. ^1 {{cite journal | vauthors = Rossignol M, Kolb-Cheynel I, Egly JM | title = Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH | journal = The EMBO Journal | volume = 16 | issue = 7 | pages = 1628–37 | date = Apr 1997 | pmid = 9130708 | pmc = 1169767 | doi = 10.1093/emboj/16.7.1628 }}
12. ^1 2 3 {{cite journal | vauthors = Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y | title = Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor | journal = Cancer Research | volume = 55 | issue = 24 | pages = 6058–62 | date = Dec 1995 | pmid = 8521393 | doi = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Jeang KT | title = Tat, Tat-associated kinase, and transcription | journal = Journal of Biomedical Science | volume = 5 | issue = 1 | pages = 24–7 | year = 1998 | pmid = 9570510 | doi = 10.1007/BF02253352 }}
- {{cite journal | vauthors = Yankulov K, Bentley D | title = Transcriptional control: Tat cofactors and transcriptional elongation | journal = Current Biology | volume = 8 | issue = 13 | pages = R447-9 | date = Jun 1998 | pmid = 9651670 | doi = 10.1016/S0960-9822(98)70289-1 }}
- {{cite journal | vauthors = Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D | title = Cdk-activating kinase complex is a component of human transcription factor TFIIH | journal = Nature | volume = 374 | issue = 6519 | pages = 283–7 | date = Mar 1995 | pmid = 7533895 | doi = 10.1038/374283a0 }}
- {{cite journal | vauthors = Aprelikova O, Xiong Y, Liu ET | title = Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 31 | pages = 18195–7 | date = Aug 1995 | pmid = 7629134 | doi = 10.1074/jbc.270.31.18195 }}
- {{cite journal | vauthors = Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA | title = Association of Cdk-activating kinase subunits with transcription factor TFIIH | journal = Nature | volume = 374 | issue = 6519 | pages = 280–2 | date = Mar 1995 | pmid = 7885450 | doi = 10.1038/374280a0 }}
- {{cite journal | vauthors = Tassan JP, Schultz SJ, Bartek J, Nigg EA | title = Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase) | journal = The Journal of Cell Biology | volume = 127 | issue = 2 | pages = 467–78 | date = Oct 1994 | pmid = 7929589 | pmc = 2120215 | doi = 10.1083/jcb.127.2.467 }}
- {{cite journal | vauthors = Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, Cavadore JC, Dorée M, Blanchard JM | title = Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase | journal = Oncogene | volume = 9 | issue = 11 | pages = 3127–38 | date = Nov 1994 | pmid = 7936635 | doi = }}
- {{cite journal | vauthors = Williams RT, Wu L, Carbonaro-Hall DA, Hall FL | title = Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells | journal = Archives of Biochemistry and Biophysics | volume = 314 | issue = 1 | pages = 99–106 | date = Oct 1994 | pmid = 7944411 | doi = 10.1006/abbi.1994.1416 }}
- {{cite journal | vauthors = Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA | title = A cyclin associated with the CDK-activating kinase MO15 | journal = Nature | volume = 371 | issue = 6494 | pages = 254–7 | date = Sep 1994 | pmid = 8078587 | doi = 10.1038/371254a0 }}
- {{cite journal | vauthors = Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB | title = Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern | journal = Oncogene | volume = 9 | issue = 7 | pages = 1977–88 | date = Jul 1994 | pmid = 8208544 | doi = }}
- {{cite journal | vauthors = Wu L, Yee A, Liu L, Carbonaro-Hall D, Venkatesan N, Tolo VT, Hall FL | title = Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase | journal = Oncogene | volume = 9 | issue = 7 | pages = 2089–96 | date = Jul 1994 | pmid = 8208556 | doi = }}
- {{cite journal | vauthors = Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y | title = Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor | journal = Cancer Research | volume = 55 | issue = 24 | pages = 6058–62 | date = Dec 1995 | pmid = 8521393 | doi = }}
- {{cite journal | vauthors = Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D | title = Three functional classes of transcriptional activation domain | journal = Molecular and Cellular Biology | volume = 16 | issue = 5 | pages = 2044–55 | date = May 1996 | pmid = 8628270 | pmc = 231191 | doi = }}
- {{cite journal | vauthors = Bartkova J, Zemanova M, Bartek J | title = Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation | journal = International Journal of Cancer | volume = 66 | issue = 6 | pages = 732–7 | date = Jun 1996 | pmid = 8647641 | doi = 10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO;2-0 }}
- {{cite journal | vauthors = Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ | title = Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6482–7 | date = Jun 1996 | pmid = 8692841 | pmc = 39049 | doi = 10.1073/pnas.93.13.6482 }}
- {{cite journal | vauthors = Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D | title = Human cyclin-dependent kinase-activating kinase exists in three distinct complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6488–93 | date = Jun 1996 | pmid = 8692842 | pmc = 39050 | doi = 10.1073/pnas.93.13.6488 }}
- {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | date = Oct 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 }}
- {{cite journal | vauthors = Parada CA, Roeder RG | title = Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain | journal = Nature | volume = 384 | issue = 6607 | pages = 375–8 | date = Nov 1996 | pmid = 8934526 | doi = 10.1038/384375a0 }}
- {{cite journal | vauthors = García-Martínez LF, Ivanov D, Gaynor RB | title = Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes | journal = The Journal of Biological Chemistry | volume = 272 | issue = 11 | pages = 6951–8 | date = Mar 1997 | pmid = 9054383 | doi = 10.1074/jbc.272.11.6951 }}
{{refend}} External links - {{MeshName|CDK7+protein,+human}}
- {{UCSC genome browser|CDK7}}
- {{UCSC gene details|CDK7}}
{{PDB Gallery|geneid=1022}}{{Cell cycle proteins}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Cyclin-dependent kinase 07}} 3 : Cell cycle|Proteins|EC 2.7.11 |