| 词条 | CYP3A7 |
| 释义 |
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3] Notable allelesThe CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[4] References1. ^{{cite journal | vauthors = Komori M, Nishio K, Ohi H, Kitada M, Kamataki T | title = Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450 | journal = J. Biochem. | volume = 105 | issue = 2 | pages = 161–3 |date=February 1989 | pmid = 2722762 | doi = }} 2. ^{{cite web | url=http://www.omim.org/entry/605340 | title=Cytochrome P450, Subfamily IIIA, Polypeptide 7 | publisher=OMIM | accessdate=March 14, 2013}} 3. ^{{cite journal | vauthors = Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M | title = Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans | journal = Pharmacogenetics | volume = 10 | issue = 5 | pages = 415–24 |date=July 2000 | pmid = 10898111 | doi = 10.1097/00008571-200007000-00005}} 4. ^CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer External links
2 : Cytochrome P450|EC 1.14.14 |
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