“Cytochalasin E”的意思、由来-开放百科全书

词条

Cytochalasin E

释义

References
External pages

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Cytochalasin E, a member of the cytochalasin group, is an inhibitor of actin polymerization in blood platelets. It inhibits angiogenesis and tumor growth. Unlike cytochalasin A and cytochalasin B, it does not inhibit glucose transport.

Because of its antiangiogenic effect, cytochalasin E is a potential drug for age-related macular degeneration, a kind of blindness caused by an abnormal proliferation of blood vessels in the eye.^[2]

Cytochalasin E was found to be a potent and selective inhibitor of bovine capillary endothelial (BCE) cell proliferation. Cytochalasin E differs from other cytochalasin molecules by having an epoxide, which is required for specificity and potency. Cytochalasin E is a potent antiangiogenic agent that may be useful for treatments of cancer and other pathologic angiogenesis.^[3]

References

1. ^Cytochalasin E from Aspergillus clavatus at Sigma-Aldrich
2. ^eyesight.org {{webarchive|url=https://web.archive.org/web/20060519050124/http://www.eyesight.org/Research/Research-Cytochalasin_E/research-cytochalasin_e.html |date=2006-05-19 }}
3. ^{{cite journal | pmid = 10900214 | volume=294 | title=Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth | date=August 2000 | journal=J. Pharmacol. Exp. Ther. | pages=421–7 | last1 = Udagawa | first1 = T | last2 = Yuan | first2 = J | last3 = Panigrahy | first3 = D | last4 = Chang | first4 = YH | last5 = Shah | first5 = J | last6 = D'Amato | first6 = RJ}}

External pages

Cytochalasin E from Fermentek
Cytochalasin E from Cayman Chemical{{biochemistry-stub}}

5 : Mycotoxins|Actin inhibitors|Carbonate esters|Epoxides|Lactones

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