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词条 DAB2
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.[1][2]

Function

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).[3]

Interactions

DAB2 has been shown to interact with:

{{div col|colwidth=20em}}
  • C-src tyrosine kinase,[4]
  • Cdk1,[5]
  • DAB2IP,[6]
  • DVL2,[7]
  • DVL3,[7]
  • LRP2,[8]
  • MYO6,[9][10]
  • Mothers against decapentaplegic homolog 2,[12]
  • Mothers against decapentaplegic homolog 3[11]
  • PIN1,[5] and
  • Src.[4]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Albertsen HM, Smith SA, Melis R, Williams B, Holik P, Stevens J, White R | title = Sequence, genomic structure, and chromosomal assignment of human DOC-2 | journal = Genomics | volume = 33 | issue = 2 | pages = 207–13 | date = January 1997 | pmid = 8660969 | pmc = | doi = 10.1006/geno.1996.0185 }}
2. ^{{cite journal | vauthors = Mok SC, Chan WY, Wong KK, Cheung KK, Lau CC, Ng SW, Baldini A, Colitti CV, Rock CO, Berkowitz RS | title = DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer | journal = Oncogene | volume = 16 | issue = 18 | pages = 2381–7 | date = June 1998 | pmid = 9620555 | pmc = | doi = 10.1038/sj.onc.1201769 }}
3. ^{{cite web | title = Entrez Gene: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1601| accessdate = }}
4. ^1 {{cite journal | vauthors = Zhou J, Scholes J, Hsieh JT | title = Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 6936–41 | date = February 2003 | pmid = 12473651 | doi = 10.1074/jbc.M210628200 }}
5. ^1 {{cite journal | vauthors = He J, Xu J, Xu XX, Hall RA | title = Cell cycle-dependent phosphorylation of Disabled-2 by cdc2 | journal = Oncogene | volume = 22 | issue = 29 | pages = 4524–30 | date = July 2003 | pmid = 12881709 | doi = 10.1038/sj.onc.1206767 }}
6. ^{{cite journal | vauthors = Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT | title = The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12622–31 | date = April 2002 | pmid = 11812785 | doi = 10.1074/jbc.M110568200 }}
7. ^1 {{cite journal | vauthors = Hocevar BA, Mou F, Rennolds JL, Morris SM, Cooper JA, Howe PH | title = Regulation of the Wnt signaling pathway by disabled-2 (Dab2) | journal = EMBO J. | volume = 22 | issue = 12 | pages = 3084–94 | date = June 2003 | pmid = 12805222 | pmc = 162138 | doi = 10.1093/emboj/cdg286 }}
8. ^{{cite journal | vauthors = Oleinikov AV, Zhao J, Makker SP | title = Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin | journal = Biochem. J. | volume = 347 Pt 3 | issue = | pages = 613–21 | date = May 2000 | pmid = 10769163 | pmc = 1220996 | doi = 10.1042/0264-6021:3470613}}
9. ^{{cite journal | vauthors = Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F | title = Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton | journal = Traffic | volume = 3 | issue = 5 | pages = 331–41 | date = May 2002 | pmid = 11967127 | doi = 10.1034/j.1600-0854.2002.30503.x}}
10. ^{{cite journal | vauthors = Inoue A, Sato O, Homma K, Ikebe M | title = DOC-2/DAB2 is the binding partner of myosin VI | journal = Biochem. Biophys. Res. Commun. | volume = 292 | issue = 2 | pages = 300–7 | date = March 2002 | pmid = 11906161 | doi = 10.1006/bbrc.2002.6636 }}
11. ^1 {{cite journal | vauthors = Hocevar BA, Smine A, Xu XX, Howe PH | title = The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway | journal = EMBO J. | volume = 20 | issue = 11 | pages = 2789–801 | date = June 2001 | pmid = 11387212 | pmc = 125498 | doi = 10.1093/emboj/20.11.2789 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Mok SC, Wong KK, Chan RK, Lau CC, Tsao SW, Knapp RC, Berkowitz RS | title = Molecular cloning of differentially expressed genes in human epithelial ovarian cancer | journal = Gynecol. Oncol. | volume = 52 | issue = 2 | pages = 247–52 | year = 1994 | pmid = 8314147 | doi = 10.1006/gyno.1994.1040 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors = Xu XX, Yi T, Tang B, Lambeth JD | title = Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2 | journal = Oncogene | volume = 16 | issue = 12 | pages = 1561–9 | year = 1998 | pmid = 9569023 | doi = 10.1038/sj.onc.1201678 }}
  • {{cite journal | vauthors = Fazili Z, Sun W, Mittelstaedt S, Cohen C, Xu XX | title = Disabled-2 inactivation is an early step in ovarian tumorigenicity | journal = Oncogene | volume = 18 | issue = 20 | pages = 3104–13 | year = 1999 | pmid = 10340382 | doi = 10.1038/sj.onc.1202649 }}
  • {{cite journal | vauthors = Tseng CP, Ely BD, Pong RC, Wang Z, Zhou J, Hsieh JT | title = The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer | journal = J. Biol. Chem. | volume = 274 | issue = 45 | pages = 31981–6 | year = 1999 | pmid = 10542228 | doi = 10.1074/jbc.274.45.31981 }}
  • {{cite journal | vauthors = Oleinikov AV, Zhao J, Makker SP | title = Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin | journal = Biochem. J. | volume = 347 Pt 3 | issue = 3 | pages = 613–21 | year = 2000 | pmid = 10769163 | pmc = 1220996 | doi = 10.1042/0264-6021:3470613 }}
  • {{cite journal | vauthors = Sheng Z, Sun W, Smith E, Cohen C, Sheng Z, Xu XX | title = Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells | journal = Oncogene | volume = 19 | issue = 42 | pages = 4847–54 | year = 2000 | pmid = 11039902 | doi = 10.1038/sj.onc.1203853 }}
  • {{cite journal | vauthors = Sheng Z, He J, Tuppen JA, Sun W, Fazili Z, Smith ER, Dong FB, Xu XX | title = Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2) | journal = Genomics | volume = 70 | issue = 3 | pages = 381–6 | year = 2000 | pmid = 11161789 | doi = 10.1006/geno.2000.6383 }}
  • {{cite journal | vauthors = Morris SM, Cooper JA | title = Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 | journal = Traffic | volume = 2 | issue = 2 | pages = 111–23 | year = 2001 | pmid = 11247302 | doi = 10.1034/j.1600-0854.2001.020206.x }}
  • {{cite journal | vauthors = Zhou J, Hsieh JT | title = The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2 | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 27793–8 | year = 2001 | pmid = 11371563 | doi = 10.1074/jbc.M102803200 }}
  • {{cite journal | vauthors = Hocevar BA, Smine A, Xu XX, Howe PH | title = The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway | journal = EMBO J. | volume = 20 | issue = 11 | pages = 2789–801 | year = 2001 | pmid = 11387212 | pmc = 125498 | doi = 10.1093/emboj/20.11.2789 }}
  • {{cite journal | vauthors = Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT | title = The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12622–31 | year = 2002 | pmid = 11812785 | doi = 10.1074/jbc.M110568200 }}
  • {{cite journal | vauthors = Inoue A, Sato O, Homma K, Ikebe M | title = DOC-2/DAB2 is the binding partner of myosin VI | journal = Biochem. Biophys. Res. Commun. | volume = 292 | issue = 2 | pages = 300–7 | year = 2002 | pmid = 11906161 | doi = 10.1006/bbrc.2002.6636 }}
  • {{cite journal | vauthors = Mishra SK, Keyel PA, Hawryluk MJ, Agostinelli NR, Watkins SC, Traub LM | title = Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor | journal = EMBO J. | volume = 21 | issue = 18 | pages = 4915–26 | year = 2002 | pmid = 12234931 | pmc = 126284 | doi = 10.1093/emboj/cdf487 }}
  • {{cite journal | vauthors = Morris SM, Tallquist MD, Rock CO, Cooper JA | title = Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport | journal = EMBO J. | volume = 21 | issue = 7 | pages = 1555–64 | year = 2002 | pmid = 11927540 | pmc = 125955 | doi = 10.1093/emboj/21.7.1555 }}
  • {{cite journal | vauthors = Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F | title = Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton | journal = Traffic | volume = 3 | issue = 5 | pages = 331–41 | year = 2002 | pmid = 11967127 | doi = 10.1034/j.1600-0854.2002.30503.x }}
  • {{cite journal | vauthors = Zhou J, Scholes J, Hsieh JT | title = Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 6936–41 | year = 2003 | pmid = 12473651 | doi = 10.1074/jbc.M210628200 }}
  • {{cite journal | vauthors = Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH | title = Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2272–7 | year = 2003 | pmid = 12606711 | pmc = 151330 | doi = 10.1073/pnas.262791999 }}
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